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Institution

Mulago Hospital

HealthcareKampala, Uganda
About: Mulago Hospital is a healthcare organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 542 authors who have published 545 publications receiving 34804 citations.


Papers
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Journal ArticleDOI
TL;DR: 7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK.
Abstract: 7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK

4 citations

Journal ArticleDOI
W. Moore1
01 Jan 1961-Tubercle
TL;DR: A case of Wegener's granulomatosis is described and the difficulties of diagnosis are discussed.

4 citations

Journal ArticleDOI
TL;DR: An automated system is described for the analysis of serum valine, alanine and glycine for use in nutrition surveys that has the advantage that the results are not expressed as ratios of amino acid concentrations but in absolute values.

4 citations

Journal ArticleDOI
15 Jul 2019-AIDS
TL;DR: Pre-ART IL-6 and TNFα were more strongly associated with hospitalization for severe malnutrition than CD4 count or viral load, highlighting the importance of inflammation at the time of ART initiation in HIV-infected children.
Abstract: Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrition in HIV-infected children. / Design: Cross-sectional laboratory sub-study in 613 HIV-infected children initiating ART in Uganda and Zimbabwe. / Methods: We measured C-reactive protein (CRP), TNFα, IL-6 and soluble CD14 by enzyme-linked immunosorbent assay in cryopreserved plasma at baseline (pre-ART) and week-4 (children with severe malnutrition only). Independent associations between baseline biomarkers and subsequent hospitalization for severe malnutrition were identified using multivariable fractional polynomial logistic regression. / Results: Compared to children without severe malnutrition (n = 574, median age 6.3 years, median baseline weight-for-age Z-score -2.2), children hospitalized for severe malnutrition post-ART (n = 39, median age 2.3 years, median baseline weight-for-age Z-score -4.8) had higher baseline CRP (median 13.5 (IQR 5.5, 41.1) versus 4.1 (1.4, 14.4) mg/L; p = 0.003) and IL-6 (median 9.2 (6.7, 15.6) versus 5.9 (4.6, 9.3) pg/mL; p 0.06). In a multivariable model, higher pre-ART IL-6, lower TNFα and lower weight-for-age were independently associated with subsequent hospitalization for severe malnutrition. Between weeks 0–4, there was a significant rise in CRP, IL-6 and sCD14, and fall in TNFα and HIV viral load in children hospitalized for severe malnutrition (all p < 0.02). / Conclusions: Pre-ART IL-6 and TNFα were more strongly associated with hospitalization for severe malnutrition than CD4 count or viral load, highlighting the importance of inflammation at the time of ART initiation in HIV-infected children.

4 citations


Authors

Showing all 545 results

NameH-indexPapersCitations
Moses R. Kamya6043512598
Jordan J. Feld5727713444
Eloi Marijon4735210005
Sarah G. Staedke471696095
Harriet Mayanja-Kizza432216804
Alphonse Okwera42885187
Joo-Hyun Nam412317216
James K Tumwine412145413
Ian Crozier401427922
Cissy Kityo391965926
Philippa Musoke371387778
Andrew Kambugu361845195
Denis Burkitt35738491
Richard Idro351394312
Robert O. Opoka331704927
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202131
202027
201929
201822
201729