Institution
Mulago Hospital
Healthcare•Kampala, Uganda•
About: Mulago Hospital is a healthcare organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 542 authors who have published 545 publications receiving 34804 citations.
Topics: Population, Health care, Tuberculosis, Referral, Kwashiorkor
Papers published on a yearly basis
Papers
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TL;DR: 7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK.
Abstract: 7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
4 citations
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TL;DR: A case of Wegener's granulomatosis is described and the difficulties of diagnosis are discussed.
4 citations
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TL;DR: An automated system is described for the analysis of serum valine, alanine and glycine for use in nutrition surveys that has the advantage that the results are not expressed as ratios of amino acid concentrations but in absolute values.
4 citations
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TL;DR: Pre-ART IL-6 and TNFα were more strongly associated with hospitalization for severe malnutrition than CD4 count or viral load, highlighting the importance of inflammation at the time of ART initiation in HIV-infected children.
Abstract: Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrition in HIV-infected children. / Design: Cross-sectional laboratory sub-study in 613 HIV-infected children initiating ART in Uganda and Zimbabwe. / Methods: We measured C-reactive protein (CRP), TNFα, IL-6 and soluble CD14 by enzyme-linked immunosorbent assay in cryopreserved plasma at baseline (pre-ART) and week-4 (children with severe malnutrition only). Independent associations between baseline biomarkers and subsequent hospitalization for severe malnutrition were identified using multivariable fractional polynomial logistic regression. / Results:
Compared to children without severe malnutrition (n = 574, median age 6.3 years, median baseline weight-for-age Z-score -2.2), children hospitalized for severe malnutrition post-ART (n = 39, median age 2.3 years, median baseline weight-for-age Z-score -4.8) had higher baseline CRP (median 13.5 (IQR 5.5, 41.1) versus 4.1 (1.4, 14.4) mg/L; p = 0.003) and IL-6 (median 9.2 (6.7, 15.6) versus 5.9 (4.6, 9.3) pg/mL; p 0.06). In a multivariable model, higher pre-ART IL-6, lower TNFα and lower weight-for-age were independently associated with subsequent hospitalization for severe malnutrition. Between weeks 0–4, there was a significant rise in CRP, IL-6 and sCD14, and fall in TNFα and HIV viral load in children hospitalized for severe malnutrition (all p < 0.02). / Conclusions: Pre-ART IL-6 and TNFα were more strongly associated with hospitalization for severe malnutrition than CD4 count or viral load, highlighting the importance of inflammation at the time of ART initiation in HIV-infected children.
4 citations
Authors
Showing all 545 results
Name | H-index | Papers | Citations |
---|---|---|---|
Moses R. Kamya | 60 | 435 | 12598 |
Jordan J. Feld | 57 | 277 | 13444 |
Eloi Marijon | 47 | 352 | 10005 |
Sarah G. Staedke | 47 | 169 | 6095 |
Harriet Mayanja-Kizza | 43 | 221 | 6804 |
Alphonse Okwera | 42 | 88 | 5187 |
Joo-Hyun Nam | 41 | 231 | 7216 |
James K Tumwine | 41 | 214 | 5413 |
Ian Crozier | 40 | 142 | 7922 |
Cissy Kityo | 39 | 196 | 5926 |
Philippa Musoke | 37 | 138 | 7778 |
Andrew Kambugu | 36 | 184 | 5195 |
Denis Burkitt | 35 | 73 | 8491 |
Richard Idro | 35 | 139 | 4312 |
Robert O. Opoka | 33 | 170 | 4927 |