Nanjing Tech University

About: Nanjing Tech University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Membrane. The organization has 21827 authors who have published 21794 publications receiving 364050 citations. The organization is also known as: Nangongda & Nánjīng Gōngyè Dàxúe.

C-reactive protein, interleukin-6 and the risk of colorectal cancer: a meta-analysis

Abstract: Many studies have evaluated the associations between pre-diagnostic circulating C-reactive protein (CRP), interleukin-6 (IL-6) and colorectal cancer risk, but their results are inconsistent. We therefore conducted a meta-analysis to investigate these associations. A comprehensive literature search up to October 2013 was undertaken in PubMed. Pooled relative risk (RR) estimates and 95 % confidence intervals (CIs) were used to calculate estimated effect. Eighteen studies on CRP comprising a total of 4,706 colorectal cancer cases were included in this meta-analysis. The summary RR of colorectal cancer for one unit change in natural logarithm (ln) CRP was 1.12 [95 % CI (1.05–1.21)]. There was statistically significant heterogeneity among studies (p = 0.006; I 2 = 51.7 %). After excluding the studies contributing most to the heterogeneity, summary estimate was essentially unchanged. In addition, the association was significant for colon cancer [RR = 1.13, 95 % CI (1.05–1.21)], not for rectal cancer [RR = 1.03, 95 % CI (0.90–1.17)]. We also found that CRP was significantly associated with increased risk of colorectal cancer among men, but not among women. There were six studies on IL-6 that involved a total of 1,068 colorectal cancer cases. The pooled RR of colorectal cancer for one unit change in ln IL-6 was 1.10 (95 % CI 0.88–1.36), and no statistically significant heterogeneity was found (p = 0.175; I 2 = 34.8 %). Our results suggest that pre-diagnostic circulating CRP is associated with increased risk of colorectal cancer. However, there is no significant association between IL-6 and colorectal cancer risk.

Resilient Control Design for Lateral Motion Regulation of Intelligent Vehicle

Abstract: This article studies the state-feedback resilient control problem for lateral motion regulation of an intelligent vehicle in the presence of randomly occurring uncertainties. First, the uncertain disturbance in an external yaw moment is compensated by the randomly occurring uncertainty when modeling the vehicle system, and a resilient controller by considering the randomly occurring uncertainty is developed, which is a more general case, but increases complexity of regulation design. Then, the resilient control condition is proposed to guarantee the sideslip angle and yaw rate satisfying the prescribed $\mathcal {H}_{\infty }$ and $\mathcal {L}_2-\mathcal {L}_\infty$ performance indexes. Moreover, $\mathcal {H}_{\infty }$ and $\mathcal {L}_2-\mathcal {L}_\infty$ performance indexes of control outputs are merged into one linear matrix inequality. Finally, an illustrative simulation is given to show the effectiveness of the proposed resilient control design.