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Institution

Nanjing Tech University

EducationNanjing, China
About: Nanjing Tech University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Membrane. The organization has 21827 authors who have published 21794 publications receiving 364050 citations. The organization is also known as: Nangongda & Nánjīng Gōngyè Dàxúe.


Papers
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Journal ArticleDOI
13 Aug 2018-ACS Nano
TL;DR: A reactive oxygen species (ROS) responsive nanoplatform is reported to successfully add up tumor oxygenation and HIF-1 functional inhibition and achieve synergistically the optimal inhibition of tumor growth.
Abstract: Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy. Here, a reactive oxygen species (ROS) responsive nanoplatform is reported to successfully add up tumor oxygenation and HIF-1 functional inhibition. This ROS responsive nanoplatform, based on manganese dioxide (MnO2) nanoparticles, delivers the HIF-1 inhibitor acriflavine and other hydrophilic cationic drugs to tumor tissues. After reacting with overexpressed hydrogen peroxide (H2O2) within tumor tissues, Mn2+ and oxygen molecules are released for magnetic resonance imaging and tumor oxygenation, respectively. Cooperating with the HIF-1 functional inhibition, the expression of tumor invasion-related signaling molecules (VEGF, MMP-9) is obviously decreased to reduce the risk of metastasis. Furthermore, the nanoplatform could relieve T-cell exhaustion via downregulation of PD-L1, whose effects are similar to the checkpoint inhibitor PD-L1 antibody, and subsequently activates tumor-specific immune responses against abscopal tumors. These therapeutic benefits including increased X-ray-induced damage, downregulated resistance, and T-cell exhaustion related proteins expression achieved synergistically the optimal inhibition of tumor growth. Overall, this designed ROS responsive nanoplatform is of great potential in the sensitization of radiation for combating primary and metastatic tumors.

180 citations

Journal ArticleDOI
TL;DR: In this paper, the authors highlight synthetic-nanomaterials-enabled channels in the platforms of well-defined nanopores, 1D nanotubes and 2D nanochannels, and discuss their design principles, channel architectures and membrane or device fabrication.
Abstract: Mass transport at the sub-nanometre scale, including selective transport of gases, liquids and ions, plays a key role in systems such as catalysis, energy generation and storage, chemical sensing and molecular separation. Highly efficient biological channels in living organisms have inspired the design of artificial channels with similar, or even higher, mass-transport efficiency, which can be used at a much larger scale. In this Review, we highlight synthetic-nanomaterials-enabled channels in the platforms of well-defined nanopores, 1D nanotubes and 2D nanochannels, and discuss their design principles, channel architectures and membrane or device fabrication. We focus on fundamental mechanisms of sub-nanometre confined mass transport and their relationships with the structure–property–performance. We then present the practicalities of these channels and discuss their potential impact on the development of next-generation sustainable technologies for use in applications related to energy, the environment and healthcare. Artificial channels that selectively transport small molecules at the sub-nanometre scale are used in many applications, but, in particular, in molecular separation. This Review discusses the design of channels, nanostructure, fabrication and mass-transport mechanisms, as well as outlining promising applications and the challenges ahead.

179 citations

Journal ArticleDOI
TL;DR: In this paper, the case of using fly ash and a local high-magnesium nickel slag (HMNS) as solid materials to manufacture geopolymer cement under the room temperature conditions was reported.

179 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the state-of-the-art developments in the field of microalgae pyrolysis and catalytic catalysts for the selective conversion of micro-algae into fine chemicals is presented.

179 citations


Authors

Showing all 22047 results

NameH-indexPapersCitations
Yi Chen2174342293080
Richard H. Friend1691182140032
Hua Zhang1631503116769
Wei Huang139241793522
Jian Zhou128300791402
Haiyan Wang119167486091
Jian Liu117209073156
Lain-Jong Li11362758035
Hong Wang110163351811
Jun-Jie Zhu10375441655
Stefan Kaskel10170536201
Hong Liu100190557561
Dirk De Vos9664233214
Peng Li95154845198
Feng Liu95106738478
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023125
2022502
20212,923
20202,572
20192,340
20181,967