Nanjing Tech University

About: Nanjing Tech University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Membrane. The organization has 21827 authors who have published 21794 publications receiving 364050 citations. The organization is also known as: Nangongda & Nánjīng Gōngyè Dàxúe.

Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin.

Abstract: Exosomes are small extracellular membrane vesicles of endocytic origin released by many cells that could be found in most body fluids. The main functions of exosomes are cellular communication and cellular waste clean-up. This study was conducted to determine the involvement of exosomes in the regulation of sensitivity of the lung cancer cell line A549 to cisplatin (DDP). When DDP was added to A549 cells, exosomes secretion was strengthened. Addition of the secreted exosomes to other A549 cells increased the resistance of these A549 cells to DDP. Upon exposure of A549 to DDP, the expression levels of several miRNAs and mRNAs reportedly associated with DDP sensitivity changed significantly in exosomes; these changes may mediate the resistance of A549 cells to DDP. Exosomes released by A549 cells during DDP exposure decreased the sensitivity of other A549 cells to DDP, which may be mediated by miRNAs and mRNAs exchange by exosomes via cell-to-cell communication. Although the detailed mechanism of resistance remains unclear, we believed that inhibition of exosomes formation and release might present a novel strategy for lung cancer treatment in the future.

High-yield synthesis of uniform Ag nanowires with high aspect ratios by introducing the long-chain PVP in an improved polyol process

Abstract: Polyvinyl pyrrolidone (PVP) with different molecular weights was used as capping agent to synthesize silver nanowires through a polyol process. The results indicated that the yields and aspect ratios of silver nanowires were controlled by the chain length of PVP and increased with increasing the molecular weight (MW) of PVP. When the long-chain PVP-K90 (MW= 800,000) was used, the product was uniform in size and was dominated by nanowires with high aspect ratios. The growth mechanism of the nanowires was studied. It is proposed that the chemical adsorption of Ag+ on the PVP chains at the initial stage promotes the growth of Ag nanowires.

High-quality CsPbBr3 perovskite nanocrystals for quantum dot light-emitting diodes

Abstract: Metal halide perovskites, such as CsPbX3 (X = Cl, Br, and I), have gained extensive attention due to their increasing demand in optoelectronic applications such as solar cells and lighting-emitting devices. Herein, we report a versatile approach to synthesize high-quality CsPbBr3 perovskite nanocrystals (sized 5–15 nm) by ligand-assisted reprecipitation at room temperature. The monodispersed CsPbBr3 nanocube perovskites displayed relatively high photoluminescence quantum yields of 50–80%. By virtue of the quantum size effects, the bandgap energies were manipulated from blue to green spectral regions (410–530 nm). In addition, through compositional modulations of the anion exchange technique, the bright photoluminescence could be almost tuned over the entire visible spectral region (450–650 nm). Furthermore, the photoluminescence of the CsPbBr3 nanocrystals was characterized by narrow emission line widths of 15–50 nm and radiative lifetimes of 5–15 ns. Finally, by taking advantage of these outstanding merits, the CsPbBr3 perovskites were successfully utilized in the application of highly fluorescent patterning and color-purity light-emitting diodes.