Institution
Nanjing University of Science and Technology
Education•Nanjing, China•
About: Nanjing University of Science and Technology is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 31581 authors who have published 36390 publications receiving 525474 citations. The organization is also known as: Nánjīng Lǐgōng Dàxué & Nánlǐgōng.
Papers published on a yearly basis
Papers
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TL;DR: A new method to predict residue-level protein contacts using inverse covariance matrix of multiple sequence alignments (MSAs) through deep residual convolutional neural network training and appropriate collection of MSAs can further improve the accuracy of final contact-map predictions.
Abstract: Motivation Contact-map of a protein sequence dictates the global topology of structural fold. Accurate prediction of the contact-map is thus essential to protein 3D structure prediction, which is particularly useful for the protein sequences that do not have close homology templates in the Protein Data Bank. Results We developed a new method, ResPRE, to predict residue-level protein contacts using inverse covariance matrix (or precision matrix) of multiple sequence alignments (MSAs) through deep residual convolutional neural network training. The approach was tested on a set of 158 non-homologous proteins collected from the CASP experiments and achieved an average accuracy of 50.6% in the top-L long-range contact prediction with L being the sequence length, which is 11.7% higher than the best of other state-of-the-art approaches ranging from coevolution coupling analysis to deep neural network training. Detailed data analyses show that the major advantage of ResPRE lies at the utilization of precision matrix that helps rule out transitional noises of contact-maps compared with the previously used covariance matrix. Meanwhile, the residual network with parallel shortcut layer connections increases the learning ability of deep neural network training. It was also found that appropriate collection of MSAs can further improve the accuracy of final contact-map predictions. The standalone package and online server of ResPRE are made freely available, which should bring important impact on protein structure and function modeling studies in particular for the distant- and non-homology protein targets. Availability and implementation https://zhanglab.ccmb.med.umich.edu/ResPRE and https://github.com/leeyang/ResPRE. Supplementary information Supplementary data are available at Bioinformatics online.
145 citations
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TL;DR: In this article, the authors investigated the mechanisms responsible for the β-to-ω and ω-toα phase transformations upon isothermal ageing at 573 K, and provided novel experimental evidence to understand the much-disputed transformation processes and elucidate the mechanism responsible for these important phase transformations.
145 citations
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TL;DR: A modified possibilistic fuzzy c-means clustering algorithm is presented for fuzzy segmentation of magnetic resonance (MR) images that have been corrupted by intensity inhomogeneities and noise, capable of utilizing local contextual information to impose local spatial continuity, thus allowing the suppression of noise and helping to resolve classification ambiguity.
145 citations
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TL;DR: In this paper, the mesoscale morphological defects within LiNi0.6Mn0.2Co 0.2O2 secondary particles were quantified using advanced synchrotron X-ray tomography.
145 citations
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TL;DR: In this paper, a feature ensemble plus sample selection (SS-FE) approach is proposed to learn a new labeling function in a feature reweighting manner, which takes labeling and instance adaptation into account.
Abstract: Domain adaptation problems often arise often in the field of sentiment classification. Here, the feature ensemble plus sample selection (SS-FE) approach is proposed, which takes labeling and instance adaptation into account. A feature ensemble (FE) model is first proposed to learn a new labeling function in a feature reweighting manner. Furthermore, a PCA-based sample selection (PCA-SS) method is proposed as an aid to FE. Experimental results show that the proposed SS-FE approach could gain significant improvements, compared to FE or PCA-SS, because of its comprehensive consideration of both labeling adaptation and instance adaptation.
145 citations
Authors
Showing all 31818 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jian Yang | 142 | 1818 | 111166 |
Liming Dai | 141 | 781 | 82937 |
Hui Li | 135 | 2982 | 105903 |
Jian Zhou | 128 | 3007 | 91402 |
Shuicheng Yan | 123 | 810 | 66192 |
Zidong Wang | 122 | 914 | 50717 |
Xin Wang | 121 | 1503 | 64930 |
Xuan Zhang | 119 | 1530 | 65398 |
Zhenyu Zhang | 118 | 1167 | 64887 |
Xin Li | 114 | 2778 | 71389 |
Zeshui Xu | 113 | 752 | 48543 |
Xiaoming Li | 113 | 1932 | 72445 |
Chunhai Fan | 112 | 702 | 51735 |
H. Vincent Poor | 109 | 2116 | 67723 |
Qian Wang | 108 | 2148 | 65557 |