Nankai University

About: Nankai University is a education organization based out in Tianjin, China. It is known for research contribution in the topics: Catalysis & Enantioselective synthesis. The organization has 42964 authors who have published 51866 publications receiving 1127896 citations. The organization is also known as: Nánkāi Dàxué.

Theranostic metal–organic framework core–shell composites for magnetic resonance imaging and drug delivery

Abstract: Metal–organic frameworks (MOFs) have shown great potential in designing theranostic probes for cancer diagnosis and therapy due to their unique properties, including versatile structures and composition, tunable particle and pore size, enormous porosity, high surface area, and intrinsic biodegradability. In this study, we demonstrate novel MOF-based theranostic Fe3O4@UiO-66 core–shell composites constructed by in situ growth of a UiO-66 MOF shell on a Fe3O4 core for simultaneous drug delivery and magnetic resonance (MR) imaging. In the composites, the UiO-66 shell is devoted for encapsulating the drug, whereas the Fe3O4 core serves as a MR contrast agent. The Fe3O4@UiO-66 core–shell composites show good biocompatibility, high drug loading capacity, sustained drug release, and outstanding MR imaging capability, as well as effective chemotherapeutic efficacy, demonstrating the feasibility of designing theranostic Fe3O4@UiO-66 core–shell composites for cancer diagnosis and therapy.

Hydrothermal Synthesis of Metal−Organic Frameworks Based on Aromatic Polycarboxylate and Flexible Bis(imidazole) Ligands

Abstract: Via hydrothermal synthesis, the self-assembly of M(II) ions, H3BTC or H2NDC with three structure-related flexible bis(imidazole) ligands, L1, L2, and L3, generated six metal−organic polymers (M = Co, Ni, Zn; BTC = 1,3,5-benzenetricarboxylate, NDC = 1,2-benzenebicarboxylate, L1 = 1,4-bis(imidazol-1-ylmethyl)benzene, L2 = 1,1′-(1,4-butanediyl)bis(imidazole), L3 = 1,1′-(1,4-hexanediyl)bis (imidazole)): {Co3(L1)3(BTC)2(μ-H2O)3·2H2O}n (1), {Zn2(L2)(HBTC)2·2H2O}n (2), {Co(L3)(HBTC)}n (3), {Co(L1) (NDC)}n (4), {Ni(L2)(NDC)}n (5), and {Co(L3) (NDC)}n (6). The structure of 1 is the rare 4-connected self-penetrating metal−organic framework (MOF) with the (63)2(64·82)2(62·84) topology notation; polymers 2 and 6 are two-dimensional (2D) (3,4)-connected and 4-connected nets, respectively. If the O−H…O/2.631 A hydrogen bonds between HBTC2− dianions are not accounted for, then polymer 3 is a 2D (3,5)-connected net; contrarily, it is a pillar-layered three-dimensional supramolecular framework characterized by (4,5)-conne...