Institution
Nanyang Technological University
Education•Singapore, Singapore•
About: Nanyang Technological University is a education organization based out in Singapore, Singapore. It is known for research contribution in the topics: Graphene & Population. The organization has 48003 authors who have published 112815 publications receiving 3294199 citations. The organization is also known as: NTU & Universiti Teknologi Nanyang.
Topics: Graphene, Population, Control theory, Artificial neural network, Laser
Papers published on a yearly basis
Papers
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TL;DR: In this article, the S100A9 protein is shown to contribute to amyloid plaque formation together with Aβ in traumatic brain injury (TBI) and Alzheimer's disease (AD).
Abstract: Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer's disease (AD). Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque formation together with Aβ. In traumatic brain injury (TBI) S100A9 itself rapidly forms amyloid plaques, which were reactive with oligomer-specific antibodies, but not with Aβ and amyloid fibrillar antibodies. They may serve as precursor-plaques for AD, implicating TBI as an AD risk factor. S100A9 was observed in some hippocampal and cortical neurons in TBI, AD and non-demented aging. In vitro S100A9 forms neurotoxic linear and annular amyloids resembling Aβ protofilaments. S100A9 amyloid cytotoxicity and native S100A9 pro-inflammatory signaling can be mitigated by its co-aggregation with Aβ, which results in a variety of micron-scale amyloid complexes. NMR and molecular docking demonstrated transient interactions between native S100A9 and Aβ. Thus, abundantly present in AD brain pro-inflammatory S100A9, possessing also intrinsic amyloidogenic properties and ability to modulate Aβ aggregation, can serve as a link between the AD amyloid and neuroinflammatory cascades and as a prospective therapeutic target.
91 citations
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TL;DR: Proteomics analysis showed that the low intracellular c-di-GMP level of DCells induced the expression of proteins required for the virulence and development of antimicrobial peptide resistance in Pseudomonas aeruginosa, contradicting the current dogma stating that dispersed cells are inevitably more susceptible to antibiotics than their sessile counterparts.
Abstract: Bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is an intracellular second messenger that controls the lifestyles of many bacteria. A high intracellular level of c-di-GMP induces a biofilm lifestyle, whereas a low intracellular level of c-di-GMP stimulates dispersal of biofilms and promotes a planktonic lifestyle. Here, we used the expression of different reporters to show that planktonic cells, biofilm cells, and cells dispersed from biofilms (DCells) had distinct intracellular c-di-GMP levels. Proteomics analysis showed that the low intracellular c-di-GMP level of DCells induced the expression of proteins required for the virulence and development of antimicrobial peptide resistance in Pseudomonas aeruginosa. In accordance with this, P. aeruginosa cells with low c-di-GMP levels were found to be more resistant to colistin than P. aeruginosa cells with high c-di-GMP levels. This finding contradicts the current dogma stating that dispersed cells are inevitably more susceptible to antibiotics than their sessile counterparts.
91 citations
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TL;DR: In this article, the pb-2 Ritz method was extended to shallow cylindrical shells of rectangular planform with arbitrary combinations of free, simply supported and clamped boundaries, along with the in-plane and transverse displacements assumed in the form of orthogonal polynomials.
91 citations
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TL;DR: A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes, leading to imidazole and quinazoline derivatives.
91 citations
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TL;DR: In this article, the adsorption mechanism of HF molecules on both intrinsic and al-doped graphene sheets is studied by first-principles calculations, and it is shown that the adorption mechanisms of the HF molecules are different for intrinsic and Al-Doped graphene.
91 citations
Authors
Showing all 48605 results
Name | H-index | Papers | Citations |
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Michael Grätzel | 248 | 1423 | 303599 |
Yang Gao | 168 | 2047 | 146301 |
Gang Chen | 167 | 3372 | 149819 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Hua Zhang | 163 | 1503 | 116769 |
Xiang Zhang | 154 | 1733 | 117576 |
Vivek Sharma | 150 | 3030 | 136228 |
Seeram Ramakrishna | 147 | 1552 | 99284 |
Frede Blaabjerg | 147 | 2161 | 112017 |
Yi Yang | 143 | 2456 | 92268 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |
Shi-Zhang Qiao | 142 | 523 | 80888 |
Paul M. Matthews | 140 | 617 | 88802 |
Bin Liu | 138 | 2181 | 87085 |
George C. Schatz | 137 | 1155 | 94910 |