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Showing papers by "National Autonomous University of Mexico published in 2004"


Journal ArticleDOI
08 Jan 2004-Nature
TL;DR: Estimates of extinction risks for sample regions that cover some 20% of the Earth's terrestrial surface show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration.
Abstract: Climate change over the past approximately 30 years has produced numerous shifts in the distributions and abundances of species and has been implicated in one species-level extinction. Using projections of species' distributions for future climate scenarios, we assess extinction risks for sample regions that cover some 20% of the Earth's terrestrial surface. Exploring three approaches in which the estimated probability of extinction shows a power-law relationship with geographical range size, we predict, on the basis of mid-range climate-warming scenarios for 2050, that 15-37% of species in our sample of regions and taxa will be 'committed to extinction'. When the average of the three methods and two dispersal scenarios is taken, minimal climate-warming scenarios produce lower projections of species committed to extinction ( approximately 18%) than mid-range ( approximately 24%) and maximum-change ( approximately 35%) scenarios. These estimates show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration.

7,089 citations



Journal ArticleDOI
J. Abraham1, Marco Aglietta, I. C. Aguirre, Michael Albrow2  +353 moreInstitutions (43)
01 May 2004
TL;DR: The first phase of the Pierre Auger Observatory has been completed and all of the sub-systems that will be used in the full instrument to be tested under field conditions as discussed by the authors.
Abstract: Construction of the first stage of the Pierre Auger Observatory has begun. The aim of the Observatory is to collect unprecedented information about cosmic rays above 1018 eV. The first phase of the project, the construction and operation of a prototype system, known as the engineering array, has now been completed. It has allowed all of the sub-systems that will be used in the full instrument to be tested under field conditions. In this paper, the properties and performance of these sub-systems are described and their success illustrated with descriptions of some of the events recorded thus far. © 2003 Elsevier B.V. All rights reserved.

775 citations


Journal ArticleDOI
TL;DR: The EcoCyc database contains carefully curated information that can be used as training sets for bioinformatics prediction of entities such as promoters, operons, genetic networks, transcription factor binding sites, metabolic pathways, functionally related genes, protein complexes and protein–ligand interactions.
Abstract: The EcoCyc database (http://EcoCyc.org/) is a comprehensive source of information on the biology of the prototypical model organism Escherichia coli K12. The mission for EcoCyc is to contain both computable descriptions of, and detailed comments describing, all genes, proteins, pathways and molecular interactions in E.coli. Through ongoing manual curation, extensive information such as summary comments, regulatory information, literature citations and evidence types has been extracted from 8862 publications and added to Version 8.5 of the EcoCyc database. The EcoCyc database can be accessed through a World Wide Web interface, while the downloadable Pathway Tools software and data files enable computational exploration of the data and provide enhanced querying capabilities that web interfaces cannot support. For example, EcoCyc contains carefully curated information that can be used as training sets for bioinformatics prediction of entities such as promoters, operons, genetic networks, transcription factor binding sites, metabolic pathways, functionally related genes, protein complexes and protein-ligand interactions.

768 citations


Journal ArticleDOI
01 Apr 2004-Nature
TL;DR: It is shown that polypod ferns (> 80% of living fern species) diversified in the Cretaceous, after angiosperms, suggesting perhaps an ecological opportunistic response to the diversification of angios perms, as angiosPerms came to dominate terrestrial ecosystems.
Abstract: The rise of angiosperms during the Cretaceous period is often portrayed as coincident with a dramatic drop in the diversity and abundance of many seed-free vascular plant lineages, including ferns. This has led to the widespread belief that ferns, once a principal component of terrestrial ecosystems, succumbed to the ecological predominance of angiosperms and are mostly evolutionary holdovers from the late Palaeozoic/early Mesozoic era. The first appearance of many modern fern genera in the early Tertiary fossil record implies another evolutionary scenario; that is, that the majority of living ferns resulted from a more recent diversification. But a full understanding of trends in fern diversification and evolution using only palaeobotanical evidence is hindered by the poor taxonomic resolution of the fern fossil record in the Cretaceous. Here we report divergence time estimates for ferns and angiosperms based on molecular data, with constraints from a reassessment of the fossil record. We show that polypod ferns (> 80% of living fern species) diversified in the Cretaceous, after angiosperms, suggesting perhaps an ecological opportunistic response to the diversification of angiosperms, as angiosperms came to dominate terrestrial ecosystems.

743 citations


Journal ArticleDOI
TL;DR: This work systematically mutagenized all 41 CR LEE genes and functionally characterized these mutants in vitro and in a murine infection model, identifying 33 virulence factors, including two virulence regulators and a hierarchical switch for type III secretion.
Abstract: Bacterial pathogenicity islands (PAI) often encode both effector molecules responsible for disease and secretion systems that deliver these effectors to host cells. Human enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli, and the mouse pathogen Citrobacter rodentium (CR) possess the locus of enterocyte effacement (LEE) PAI. We systematically mutagenized all 41 CR LEE genes and functionally characterized these mutants in vitro and in a murine infection model. We identified 33 virulence factors, including two virulence regulators and a hierarchical switch for type III secretion. In addition, 7 potential type III effectors encoded outside the LEE were identified by using a proteomics approach. These non-LEE effectors are encoded by three uncharacterized PAIs in EHEC O157, suggesting that these PAIs act cooperatively with the LEE in pathogenesis. Our findings provide significant insights into bacterial virulence mechanisms and disease.

604 citations


Journal ArticleDOI
TL;DR: A previously unknown function of Oct4 in maintaining viability of mammalian germline is suggested using the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs).
Abstract: Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development. We have used the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs). Loss of Oct4 function leads to apoptosis of PGCs rather than to differentiation into a trophectodermal lineage, as has been described for Oct4-deficient ICM cells. These new results suggest a previously unknown function of Oct4 in maintaining viability of mammalian germline.

554 citations


Journal ArticleDOI
TL;DR: In this paper, a new classification of neutron star cooling scenarios, involving either "minimal" cooling or "enhanced" cooling, is proposed, which is distinguished from enhanced cooling by the absence of neutrino emission from any direct Urca process, due either to nucleons or to exotica such as hyperons or deconfined quarks.
Abstract: A new classification of neutron star cooling scenarios, involving either "minimal" cooling or "enhanced" cooling, is proposed. The minimal cooling scenario replaces and extends the so-called standard cooling scenario to include neutrino emission from the Cooper pair breaking and formation process. This emission dominates that due to the modified Urca process for temperatures close to the critical temperature for superfluid pairing. Minimal cooling is distinguished from enhanced cooling by the absence of neutrino emission from any direct Urca process, due either to nucleons or to exotica such as hyperons, Bose condensates, or deconfined quarks. Within the minimal cooling scenario, theoretical cooling models can be considered to be a four parameter family involving the equation of state (including various compositional possibilities) of dense matter, superfluid properties of dense matter, the composition of the neutron star envelope, and the mass of the neutron star. The consequences of minimal cooling are explored through extensive variations of these parameters. The results are compared with the inferred properties of thermally emitting neutron stars in order to ascertain if enhanced cooling occurs in any of them. All stars for which thermal emissions have been clearly detected are at least marginally consistent with the lack of enhanced cooling, given the combined uncertainties in ages and temperatures or luminosities. The two pulsars PSR 0833-45 (Vela) and PSR 1706-44 would require enhanced cooling in case their ages and/or temperatures are on the lower side of their estimated values, whereas the four stars PSR 0656+14, PSR 1055-52, Geminga, and RX J0720.4-3125 may require some source of internal heating in case their age and/or luminosity are on the upper side of their estimated values. The new upper limits on the thermal luminosity of PSR J0205+6449 (in the supernova remnant 3C 58) and RX J0007.0+7302 (in CTA 1) are indicative of the occurrence of some enhanced neutrino emission beyond the minimal scenario.

512 citations


Journal ArticleDOI
TL;DR: In this article, the electronic properties and the geometric structure of noble metal clusters were studied and the trend for the cohesive energy, ionization potentials, electron affinities, and highest accupied and lowest unoccupied molecular orbital gap was analyzed in detail for each noble metal and rationalized in terms of two-and three-dimensional electronic shell models.
Abstract: We present a systematic study of the electronic properties and the geometric structure of noble metal clusters ${X}_{n}^{\ensuremath{ u}}$ ($X=\mathrm{Cu}$, Ag, Au; $\ensuremath{ u}=\ensuremath{-}1,0,+1$; $n\ensuremath{\leqslant}13$ and $n=20$), obtained from first-principles generalized gradient approximation density functional calculations based on norm-conserving pseudopotentials and numerical atomic basis sets. We obtain planar structures for the ground state of anionic $(\ensuremath{ u}=\ensuremath{-}1)$, neutral $(\ensuremath{ u}=0)$, and cationic $(\ensuremath{ u}=1)$ species of gold clusters with up to 12, 11, and 7 atoms, respectively. In contrast, the maximum size of planar clusters with $\ensuremath{ u}=\ensuremath{-}1,0,+1$ are $n=(5,6,5)$ for silver and (5,6,4) for copper. For ${X}_{20}$ we find a ${T}_{d}$ symmetry for gold and a compact ${C}_{s}$ structure for silver and copper. Our results for the cluster geometries agree partially with previous first-principles calculations, and they are in good agreement with recent experimental results for anionic and cationic gold clusters. The tendency to planarity of gold clusters, which is much larger than in copper and silver, is strongly favored by relativistic effects, which decrease the $s\text{\ensuremath{-}}d$ promotion energy and lead to hybridization of the half-filled $6s$ orbital with the fully occupied $5{d}_{{z}^{2}}$ orbital. That picture is substantiated by analyzing our calculated density matrix for planar and three-dimensional clusters of gold and copper. The trends for the cohesive energy, ionization potentials, electron affinities, and highest accupied and lowest unoccupied molecular orbital gap, as the cluster size increases, are studied in detail for each noble metal and rationalized in terms of two- and three-dimensional electronic shell models. The most probable fragmentation channels for ${X}_{n}^{\ensuremath{ u}}$ clusters are in very good agreement with available experiments.

500 citations


Journal ArticleDOI
TL;DR: Exposure to severe airpollution is associated with brain inflammation and Aβ 42 accumulation, two causes of neuronal dysfunction that precede the appearance of neuritic plaques and neurofibrillary tangles, hallmarks of Alzheimer's disease.
Abstract: Air pollution is a complex mixture of gases (e.g., ozone), particulate matter, and organic compounds present in outdoor and indoor air. Dogs exposed to severe air pollution exhibit chronic inflammation and acceleration of Alzheimer's-like pathology, suggesting that the brain is adversely affected by pollutants. We investigated whether residency in cities with high levels of air pollution is associated with human brain inflammation. Expression of cyclooxygenase-2 (COX2), an inflammatory mediator, and accumulation of the 42-amino acid form of beta-amyloid (Abeta42), a cause of neuronal dysfunction, were measured in autopsy brain tissues of cognitively and neurologically intact lifelong residents of cities having low (n:9) or high (n:10) levels of air pollution. Genomic DNA apurinic/apyrimidinic sites, nuclear factor-kappaB activation and apolipoprotein E genotype were also evaluated. Residents of cities with severe air pollution had significantly higher COX2 expression in frontal cortex and hippocampus and greater neuronal and astrocytic accumulation of Abeta42 compared to residents in low air pollution cities. Increased COX2 expression and Abeta42 accumulation were also observed in the olfactory bulb. These findings suggest that exposure to severe air pollution is associated with brain inflammation and Abeta42 accumulation, two causes of neuronal dysfunction that precede the appearance of neuritic plaques and neurofibrillary tangles, hallmarks of Alzheimer's disease.

496 citations


Journal ArticleDOI
TL;DR: In this article, the authors used the Hubble Space Telescope ultraviolet spectra and supporting ground-based data for a sample of nine intermediate-mass T T Tauri stars (IMTTSs; 1.5-4 M⊙).
Abstract: We present Hubble Space Telescope ultraviolet spectra and supporting ground-based data for a sample of nine intermediate-mass T Tauri stars (IMTTSs; 1.5–4 M⊙). The targets belong to three star-forming regions: T Tau, SU Aur, and RY Tau in the Taurus clouds; EZ Ori, P2441, and V1044 Ori in the Ori OB1c association surrounding the Orion Nebula cluster; and CO Ori, GW Ori, and GX Ori in the ring around λ Ori. The supporting ground-based observations include nearly simultaneous UBV(R I)C photometry, 6 A resolution spectra covering the range 3900–7000 A, optical echelle observations in the range 5800–8600 A, and K-band near-infrared spectra. We use these data to determine improved spectral types and reddening corrections and to obtain physical parameters of the targets. We find that an extinction law with a weak 2175 A feature but high values of AUV/AV is required to explain the simultaneous optical-UV data; the reddening laws for two B-type stars located behind the Taurus clouds, HD 29647 and HD 283809, meet these properties. We argue that reddening laws with these characteristics may well be representative of cold, dense molecular clouds. Spectral energy distributions and emission-line profiles of the IMTTSs are consistent with expectations from magnetospheric accretion models. We compare our simultaneous optical-UV data with predictions from accretion shock models to get accretion luminosities and mass accretion rates () for the targets. We find that the average mass accretion rate for IMTTSs is ~3 × 10-8 M⊙ yr-1, a factor of ~5 higher than that for their low-mass counterparts. The new data extend the correlation between and stellar mass to the intermediate-mass range. Since the IMTTSs are evolutionary descendants of the Herbig Ae/Be stars, our results put limits to the mass accretion rates of their disks. We present luminosities of the UV lines of highly ionized metals and show that they are well above the saturation limit for magnetically active cool stars but correlate strongly with accretion luminosity, indicating that they are powered by accretion, in agreement with previous claims but using a sample in which reddening and accretion luminosities have been determined self-consistently. Finally, we find that the relation between accretion luminosity and Brγ luminosity found for low-mass T Tauri stars extends to the intermediate-mass regime.

Journal ArticleDOI
TL;DR: In this article, Petrographic, major, trace, and rare earth element compositions of sandstones from the upper Miocene Kudankulam Formation, Southern India, have been investigated to determine their provenance, tectonic setting, and weathering conditions.
Abstract: Petrographic, major, trace, and rare earth element compositions of sandstones from the upper Miocene Kudankulam Formation, Southern India, have been investigated to determine their provenance, tectonic setting, and weathering conditions. All sandstone samples are highly enriched in quartz (Q) but poor in feldspar (F) and lithic fragments (L). The major-element concentrations of these sandstones reveal the relative homogeneity of their source. Geochemically, the Kudankulam sandstones are classified as arkose, subarkose, litharenite, and sublitharenite. The CIA values (chemical index of alteration; mean value 44.5) for these sandstones and the A-CN-K diagram suggest their low-weathering nature. Similarly, their Fe2O3* + MgO (mean 2.7), Al2O3/SiO2 ( 0.09), K2O/Na2O ( 2.2) ratios and TiO2 contents ( 0.3) are consistent with a passive-margin setting. The Eu/Eu* ( 0.5), (La/Lu)cn ( 21), La/Sc ( 5.9), Th/Sc ( 1.9), La/Co ( 5.7), Th/Co ( 1.8), and Cr/Th ( 5.3) ratios support a felsic source for these sandstones. Chondrite-normalized REE patterns with LREE enrichment, flat HREE, and negative Eu anomaly also are attributed to felsic source-rock characteristics for Kudankulam sandstones. Total REE concentrations of these sandstones reflect the variations in their grain-size fractions. The source rocks are probably identified to be Proterozoic gneisses, charnockites, and granites of the Kerala Khondalite Belt, which must have been exposed at least since the late Miocene. Finally, the unusual Ni enrichment in the Kudankulam sandstones, unaccompanied by a similar enrichment in Cr, Co, and V, may be related to either the presence of pyrite in the sandstones or, more likely, the fractionation of garnet from the source rocks during transportation.

Journal ArticleDOI
TL;DR: In this article, the authors present longitudinal studies of 23 extant mammal species, modelling ecological niches and predicting geographical distributions reciprocally between the Last Glacial Maximum and present to test this evolutionary conservatism.
Abstract: Aim Theoretical work suggests that species’ ecological niches should remain relatively constant over long-term ecological time periods, but empirical tests are few. We present longitudinal studies of 23 extant mammal species, modelling ecological niches and predicting geographical distributions reciprocally between the Last Glacial Maximum and present to test this evolutionary conservatism. Location This study covered distributional shifts in mammal species across the lower 48 states of the United States.

Journal ArticleDOI
TL;DR: In this paper, the authors examined pre-earthquake ionospheric anomalies by the total electron content (TEC) derived from a ground-based receiver of the Global Positioning System (GPS).
Abstract: . In this paper we examine pre-earthquake ionospheric anomalies by the total electron content (TEC) derived from a ground-based receiver of the Global Positioning System (GPS). A 15-day running median of the TEC and the associated inter-quartile range (IQR) are utilized as a reference for identifying abnormal signals during all of the 20M≥6.0 earthquakes in the Taiwan area from September 1999 to December 2002. Results show that the pre-earthquake ionospheric anomalies appear during 18:00–22:00LT (LT=UT+8h) within 5 days prior to 16 of the 20M≥6.0 earthquakes. This success rate of 80% (=16/20%) suggests that the GPS TEC is useful to register pre-earthquake ionospheric anomalies appearing before large earthquakes. Key words. Ionosphere (ionospheric disturbances; ionosphere-atmosphere interactions)

Journal ArticleDOI
TL;DR: It is suggested that future research be warranted that will define the possible use of saffron as effective anticancer and chemopreventive agent in clinical trials.

Journal ArticleDOI
TL;DR: In this article, the binding trend of Au(III) to oat and the possible formation of Au nanoparticles was studied for a period of 1 h at pH values ranging from 2 to 6.
Abstract: Oat (Avena sativa) biomass was studied as an alternative to recover Au(III) ions from aqueous solutions and for its capacity to reduce Au(III) to Au(0) forming Au nanoparticles. To study the binding trend of Au(III) to oat and the possible formation of Au nanoparticles, the biomass and a solution of Au(III) were reacted for a period of 1 h at pH values ranging from 2 to 6. The results demonstrated that Au(III) ions were bound to oat biomass in a pH-dependent manner, with the highest adsorption (about 80%) at pH 3. HRTEM studies showed that oat biomass reacted with Au(III) ions formed Au nanoparticles of fcc tetrahedral, decahedral, hexagonal, icosahedral multitwinned, irregular, and rod shape. To our knowledge, this is the second report about the production of nanorods as a product of the reaction of a Au(III) solution with a biological material. These studies also showed that the pH of the reaction influenced the nanoparticle size. The smaller nanoparticles and the higher occurrence of these were observed at pH values of 3 and 4, whereas the larger nanoparticles were observed at pH 2.

Journal ArticleDOI
TL;DR: In this paper, the authors describe the foraging patterns of free-ranging spider monkeys (Ateles geoffroyi) in the forest of the Yucatan Peninsula, Mexico and find that these patterns closely resemble what physicists know as Levy walks.
Abstract: Scale invariant patterns have been found in different biological systems, in many cases resembling what physicists have found in other, nonbiological systems. Here we describe the foraging patterns of free-ranging spider monkeys (Ateles geoffroyi) in the forest of the Yucatan Peninsula, Mexico and find that these patterns closely resemble what physicists know as Levy walks. First, the length of a trajectory’s constituent steps, or continuous moves in the same direction, is best described by a power-law distribution in which the frequency of ever larger steps decreases as a negative power function of their length. The rate of this decrease is very close to that predicted by a previous analytical Levy walk model to be an optimal strategy to search for scarce resources distributed at random. Second, the frequency distribution of the duration of stops or waiting times also approximates to a power-law function. Finally, the mean square displacement during the monkeys’ first foraging trip increases more rapidly than would be expected from a random walk with constant step length, but within the range predicted for Levy walks. In view of these results, we analyze the different exponents characterizing the trajectories described by females and males, and by monkeys on their own and when part of a subgroup. We discuss the origin of these patterns and their implications for the foraging ecology of spider monkeys.

Journal ArticleDOI
TL;DR: The network proposed here provides a dynamical explanation for the ABC model and shows that precise signaling pathways are not required to restrain cell types to those found in Arabidopsis, but these are rather determined by the overall gene network dynamics.
Abstract: Flowers are icons in developmental studies of complex structures. The vast majority of 250,000 angiosperm plant species have flowers with a conserved organ plan bearing sepals, petals, stamens, and carpels in the center. The combinatorial model for the activity of the so-called ABC homeotic floral genes has guided extensive experimental studies in Arabidopsis thaliana and many other plant species. However, a mechanistic and dynamical explanation for the ABC model and prevalence among flowering plants is lacking. Here, we put forward a simple discrete model that postulates logical rules that formally summarize published ABC and non-ABC gene interaction data for Arabidopsis floral organ cell fate determination and integrates this data into a dynamic network model. This model shows that all possible initial conditions converge to few steady gene activity states that match gene expression profiles observed experimentally in primordial floral organ cells of wild-type and mutant plants. Therefore, the network proposed here provides a dynamical explanation for the ABC model and shows that precise signaling pathways are not required to restrain cell types to those found in Arabidopsis, but these are rather determined by the overall gene network dynamics. Furthermore, we performed robustness analyses that clearly show that the cell types recovered depend on the network architecture rather than on specific values of the model's gene interaction parameters. These results support the hypothesis that such a network constitutes a developmental module, and hence provide a possible explanation for the overall conservation of the ABC model and overall floral plan among angiosperms. In addition, we have been able to predict the effects of differences in network architecture between Arabidopsis and Petunia hybrida.

Journal ArticleDOI
TL;DR: The data suggest that the two receptors of Cry1Ab toxin interact sequentially with different structural species of the toxin leading to its efficient membrane insertion.

Journal ArticleDOI
TL;DR: In this paper, the full characterization of chitin obtained from squid, shrimp, prawn, lobsters, and king crabs is reported, and the morphology was studied by means of TEM and their compositions were determined by energy-dispersive X-ray analysis.
Abstract: The full characterization of chitin obtained from squid, shrimp, prawn, lobsters, and king crab is reported. Elemental analysis, including metals such as Ca, Mg, Zn, Cd, Hg, Cr, Mn, Cu, and Pb, was performed, which is quite relevant because the skeleton composition is slightly different for each species. The morphology was studied by means of TEM and their compositions were determined by energy-dispersive X-ray analysis. 13C cross polarization/magic angle spinning NMR was applied to determine the chemical shift of all the carbons and the difference between them. Chitin was isolated by using chemical methods, alternating hydrochloric acid and sodium hydroxide. The α-chitin from shrimp, prawn, lobsters, and king crabs showed two signals at 73.7 and 75.6 ppm. Meanwhile, the β-chitin from squid exhibited one signal at 75.2 ppm. FTIR studies were used to analyze α-chitin from shrimp and β-chitin from squid. The α-chitin exhibited amide I vibration modes at 1660 and 1627 cm−1, whereas the β-chitin showed one band at 1656 cm−1. X-ray diffraction showed that α-chitin is orthorhombic (a = 4.74 A, b = 18.86 A, and c = 10.32 A) and β-chitin had a monoclinic dihydrated form (a = 4.80 A, b = 10.40 A, c = 11.10 A, and β = 97°). © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 1876–1885, 2004


Journal ArticleDOI
TL;DR: The findings indicate that each coral species hosts a distinct algal taxon adapted to a particular light regime, which constitutes an important axis for niche diversification and is sufficient to explain the vertical distribution patterns of these two coral species.
Abstract: Symbiotic reef corals occupy the entire photic zone; however, most species have distinct zonation patterns within the light intensity gradient. It is hypothesized that the presence of specific symbionts adapted to different light regimes may determine the vertical distribution of particular hosts. We have tested this hypothesis by genetic and in situ physiological analyses of the algal populations occupying two dominant eastern Pacific corals, over their vertical distribution in the Gulf of California. Our findings indicate that each coral species hosts a distinct algal taxon adapted to a particular light regime. The differential use of light by specific symbiotic dinoflagellates constitutes an important axis for niche diversification and is sufficient to explain the vertical distribution patterns of these two coral species.

Journal ArticleDOI
TL;DR: By combining presences of species data with electronic cartography via a number of algorithms, estimating niches of species and their areas of distribution becomes feasible at resolutions one to three orders of magnitude higher than it was possible a few years ago.
Abstract: Recently, advances in information technology and an increased willingness to share primary biodiversity data are enabling unprecedented access to it. By combining presences of species data with electronic cartography via a number of algorithms, estimating niches of species and their areas of distribution becomes feasible at resolutions one to three orders of magnitude higher than it was possible a few years ago. Some examples of the power of that technique are presented. For the method to work, limitations such as lack of high-quality taxonomic determination, precise georeferencing of the data and availability of high-quality and updated taxonomic treatments of the groups must be overcome. These are discussed, together with comments on the potential of these biodiversity informatics techniques not only for fundamental studies but also as a way for developing countries to apply state of the art bioinformatic methods and large quantities of data, in practical ways, to tackle issues of biodiversity management.

Journal ArticleDOI
TL;DR: It is reported that overexpression of AtTPS1 in Arabidopsis using the 35S promoter led to a small increase in Trehalose and trehalose-6-P levels, which strongly suggest that AtTPS 1 has a pivotal role in the regulation of Glc and ABA signaling during vegetative development.
Abstract: In Arabidopsis (Arabidopsis thaliana), trehalose is present at almost undetectable levels, excluding its role as an osmoprotectant. Here, we report that overexpression of AtTPS1 in Arabidopsis using the 35S promoter led to a small increase in trehalose and trehalose-6-P levels. In spite of this, transgenic plants displayed a dehydration tolerance phenotype without any visible morphological alterations, except for delayed flowering. Moreover, seedlings overexpressing AtTPS1 exhibited glucose (Glc)and abscisic acid (ABA)-insensitive phenotypes. Transgenic seedlings germinated on Glc were visibly larger with green wellexpanded cotyledonary leaves and fully developed roots, in contrast with wild-type seedlings showing growth retardation and absence of photosynthetic tissue. An ABA dose-response experiment revealed a higher germination rate for transgenic plants overexpressing AtTPS1 showing insensitive germination kinetics at 2.5 mM ABA. Interestingly, germination in the presence of Glc did not trigger an increase in ABA content in plants overexpressing AtTPS1. Expression analysis by quantitative reverse transcription-PCR in transgenic plants showed up-regulation of the ABI4 and CAB1 genes. In the presence of Glc, CAB1 expression remained high, whereas ABI4, HXK1, and ApL3 levels were down-regulated in the AtTPS1-overexpressing lines. Analysis of AtTPS1 expression in HXK1-antisense or HXK1-sense transgenic lines suggests the possible involvement of AtTPS1 in the hexokinase-dependent Glc-signaling pathway. These data strongly suggest that AtTPS1 has a pivotal role in the regulation of Glc and ABA signaling during vegetative development.

Journal ArticleDOI
08 Jan 2004-Neuron
TL;DR: It is reported that the activity of VPC neurons reflects current and remembered sensory inputs, their comparison, and motor commands expressing the result; that is, the entire processing cascade linking the evaluation of sensory stimuli with a motor report.

Journal ArticleDOI
15 Jun 2004-Toxicon
TL;DR: The evolutionary tree indicates that several clusters of divergent peptides show preference for specific subtypes of channels, and four different interacting modes were identified to exist between scorpion toxins and the various sub types of K+-channels.

Journal ArticleDOI
TL;DR: In this article, the authors present a gas dynamical simulation of the photoevaporation of cosmological minihaloes overtaken by the ionization fronts which swept through the IGM during the reionization epoch in the currently favored A cold dark matter (ACDM) universe, including the effects of radiative transfer.
Abstract: Energy released by a small fraction of the baryons in the Universe, which condensed out while the intergalactic medium (IGM) was cold, dark and neutral, reheated and reionized it by redshift 6, exposing other baryons already condensed into dwarf-galaxy minihaloes to the glare of ionizing radiation. We present the first gas dynamical simulations of the photoevaporation of cosmological minihaloes overtaken by the ionization fronts which swept through the IGM during the reionization epoch in the currently favoured A cold dark matter (ACDM) universe, including the effects of radiative transfer. These simulations demonstrate the phenomenon of I-front trapping inside minihaloes, in which the weak, R-type fronts which travelled supersonically across the IGM decelerated when they encountered the dense, neutral gas inside minihaloes, and were thereby transformed into D-type I-fronts, preceded by shock waves. For a minihalo with virial temperature below 10 4 K, the I-front gradually burned its way through the minihalo which trapped it, removing all of its baryonic gas by causing a supersonic, evaporative wind to blow backwards into the IGM, away from the exposed layers of minihalo gas just behind the advancing I-front. We describe this process in detail, along with some of its observable consequences, for the illustrative case of a minihalo of total mass 10 7 M ○. , exposed to a distant source of ionizing radiation with either a stellar or quasar-like spectrum, after it was overtaken at redshift z = 9 by the weak, R-type I-front which ionized the IGM surrounding the source. For a source at z = 9 which emits 10 56 ionizing photons per second at 1 Mpc (or, equivalently, 10 52 ionizing photons per second at 10 kpc), the photoevaporation of this minihalo takes about 100-150 Myr, depending on the source spectrum, ending at about z = 7.5. Such hitherto neglected feedback effects were widespread during the reionization epoch. N-body simulations and analytical estimates of halo formation in the ACDM model suggest that sub-kpc minihaloes such as these, with virial temperatures below 10 4 K, were so common as to cover the sky around larger-mass source haloes and possibly dominate the absorption of ionizing photons during reionization. This means that previous estimates of the number of ionizing photons per hydrogen atom required to complete reionization which neglected this effect may be too low. Regardless of their effect on the progress of reionization, however, the minihaloes were so abundant that random lines of sight through the high-z Universe should encounter many of them, which suggests that it may be possible to observe the processes described here in the absorption spectra of distant sources.

Journal ArticleDOI
David P. Schmitt1, Lidia Alcalay2, Melissa Allensworth1, Jüri Allik3, Lara Ault4, Ivars Austers5, Kevin Bennett6, Gabriel Bianchi7, Fredrick Boholst8, Mary Ann Borg Cunen9, Johan Braeckman10, Edwin G. Brainerd11, Leo Gerard A. Caral8, Gabrielle Caron, María Martina Casullo12, Michael Cunningham4, Ikuo Daibo13, Charlotte J. S. De Backer10, Eros De Souza14, Rolando Díaz-Loving15, Glaucia Ribeiro Starling Diniz16, Kevin Durkin17, Marcela Echegaray18, Ekin Eremsoy19, Harald A. Euler20, Ruth Falzon9, Maryanne L. Fisher21, Dolores Foley22, Robert Fowler1, Douglas P. Fry23, Sirpa Fry23, M. Arif Ghayur24, Vijai N. Giri25, Debra L. Golden26, Karl Grammer, Liria Grimaldi27, Jamin Halberstadt28, Shamsul Haque29, Dora Herrera18, Janine Hertel30, Amanda Hitchell1, Heather Hoffmann31, Danica Hooper22, Zuzana Hradilekova32, Jasna Hudek-Kene-Evi33, Allen I. Huffcutt1, Jas Laile Suzana Binti Jaafar34, Margarita Jankauskaite35, Heidi Kabangu-Stahel, Igor Kardum33, Brigitte Khoury36, Hayrran Kwon37, Kaia Laidra3, Anton Laireiter38, Dustin Lakerveld39, Ada Lampert, Mary Anne Lauri9, Marguerite Lavallée, Suk-Jae Lee40, Luk Chung Leung41, Kenneth D. Locke42, Vance Locke17, Ivan Lukšík7, Ishmael Magaisa43, Dalia Marcinkeviciene35, André Mata44, Rui Mata44, Barry Mccarthy45, Michael E. Mills46, Nhlanhla Mkhize47, João Manuel Moreira44, Sérgio Moreira44, Miguel Moya48, M. Munyae49, Patricia Noller22, Hmoud Olimat50, Adrian Opre51, Alexia Panayiotou52, Nebojša Petrović53, Karolien Poels10, Miroslav Popper7, Maria Poulimenou54, Volodymyr P'Yatokha, Michel Raymond55, Ulf-Dietrich Reips56, Susan E. Reneau57, Sofía Rivera-Aragón15, Wade C. Rowatt58, Willibald Ruch59, Velko S. Rus60, Marilyn P. Safir61, Sonia Salas62, Fabio Sambataro27, Kenneth Sandnabba23, Rachel Schleeter1, Marion K. Schulmeyer, Astrid Schütz30, Tullio Scrimali27, Todd K. Shackelford63, Mithila B. Sharan25, Phillip R. Shaver64, Francis J Sichona65, Franco Simonetti2, Tilahun Sineshaw66, R. Sookdew47, Tom Speelman10, Spyros Spyrou67, H. Canan Sümer, Nebi Sümer68, Marianna Supekova7, Tomasz Szlendak, Robin Taylor69, Bert Timmermans70, William Tooke71, Ioannis Tsaousis72, F. S.K. Tungaraza65, Ashley Turner1, Griet Vandermassen10, Tim Vanhoomissen73, Frank Van Overwalle73, Ine Vanwesenbeeck, Paul L. Vasey74, João Veríssimo44, Martin Voracek75, Wendy W.N. Wan76, Ta-Wei Wang77, Peter Weiss78, Andik Wijaya, Liesbeth Woertman39, Gahyun Youn79, Agata Zupanèiè60 
Bradley University1, Pontifical Catholic University of Chile2, University of Tartu3, University of Louisville4, University of Latvia5, University of New Mexico6, Slovak Academy of Sciences7, University of San Carlos8, University of Malta9, Ghent University10, Clemson University11, University of Buenos Aires12, Osaka University13, Illinois State University14, National Autonomous University of Mexico15, University of Brasília16, University of Western Australia17, University of Lima18, Boğaziçi University19, University of Kassel20, University of York21, University of Queensland22, Åbo Akademi University23, Al Akhawayn University24, Indian Institute of Technology Kharagpur25, University of Hawaii at Manoa26, University of Catania27, University of Otago28, University of Dhaka29, Chemnitz University of Technology30, Knox College31, Comenius University in Bratislava32, University of Rijeka33, University of Malaya34, Vilnius University35, American University of Beirut36, Kwangju Health College37, University of Salzburg38, Utrecht University39, National Computerization Agency40, City University of Hong Kong41, University of Idaho42, University of Zimbabwe43, University of Lisbon44, University of Central Lancashire45, Loyola Marymount University46, University of Natal47, University of Granada48, University of Botswana49, University of Jordan50, Babeș-Bolyai University51, University of Cyprus52, University of Belgrade53, KPMG54, University of Montpellier55, University of Zurich56, University of Alabama57, Baylor University58, Queen's University Belfast59, University of Ljubljana60, University of Haifa61, University of La Serena62, Florida Atlantic University63, University of California, Davis64, University of Dar es Salaam65, Ramapo College66, Cyprus College67, Middle East Technical University68, University of the South Pacific69, VU University Amsterdam70, State University of New York System71, University of the Aegean72, Vrije Universiteit Brussel73, University of Lethbridge74, University of Vienna75, University of Hong Kong76, Yuan Ze University77, Charles University in Prague78, Chonnam National University79
TL;DR: In the International Sexuality Description Project, a total of 17,804 participants from 62 cultural regions completed the RelationshipQuestionnaire (RQ), a self-report measure of adult romantic attachment as discussed by the authors.
Abstract: As part of the International Sexuality Description Project, a total of 17,804 participants from 62 cultural regions completedthe RelationshipQuestionnaire(RQ), a self-reportmeasure of adult romanticattachment. Correlational analyses within each culture suggested that the Model of Self and the Model of Other scales of the RQ were psychometrically valid within most cultures. Contrary to expectations, the Model of Self and Model of Other dimensions of the RQ did not underlie the four-category model of attachment in the same way across all cultures. Analyses of specific attachment styles revealed that secure romantic attachment was normative in 79% of cultures and that preoccupied romantic attachment was particularly prevalent in East Asian cultures. Finally, the romantic attachment profiles of individual nations were correlated with sociocultural indicators in ways that supported evolutionary theories of romantic attachment and basic human mating strategies.

Journal ArticleDOI
01 Jan 2004-Geology
TL;DR: In this paper, the authors use the Neogene geologic record of central Mexico to propose a lateral propagation of slab detachment beneath the Trans-Mexican volcanic belt during the late Miocene.
Abstract: Seismic tomography studies and plate reconstructions suggest that the Farallon slab broke off shortly before subduction ended off southern Baja California. However, the progress of detachment in time and space and its consequences on the volcanism of central Mexico have not so far been considered. Here I use the Neogene geologic record of central Mexico to propose a lateral propagation of slab detachment beneath the Trans-Mexican volcanic belt during the late Miocene. I suggest that the trace of the detachment is expressed by a short (2–3 m.y.), eastward-migrating pulse of mafic volcanism that took place from ca. 11.5 to ca. 6 Ma to the north of the Pliocene–Quaternary volcanic arc, as hot, subslab material flowing into the slab gap produced a transitory thermal anomaly in the mantle wedge. Slab detachment of the deeper and denser part of the plate was initiated in the southern Gulf of California area by the incoming of progressively younger oceanic lithosphere at the paleotrench that produced an increasing coupling between the Magdalena microplate and the overriding North American plate. The tear in the slab propagated eastward from the Gulf of California to the Gulf of Mexico, paralleling the southern Mexico trench system. The decrease in the Rivera–North America convergence rate between ca. 9 and 7 Ma appears to be related to the loss of slab pull after the detachment. Sparse oceanic-island–type basalts emplaced since the end of the Miocene in the Trans-Mexican volcanic belt are located above a trench-parallel slab window between the inferred detachment trace and the leading edge of the present slab, which has been detected seismically. In this context, the occurrence of these unusual intraplate magmas is easily explained by the infiltration of enriched asthenosphere into the subarc mantle.

Journal ArticleDOI
TL;DR: It is explained that combining known elementary particle interactions with a Planck-scale preferred frame gives rise to Lorentz violation at the percent level, some 20 orders of magnitude higher than earlier estimates, unless the bare parameters of the theory are unnaturally strongly fine tuned.
Abstract: Trying to combine standard quantum field theories with gravity leads to a breakdown of the usual structure of space time at around the Planck length, $1.6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}35}\text{ }\text{ }\mathrm{m}$, with possible violations of Lorentz invariance. Calculations of preferred-frame effects in quantum gravity have further motivated high precision searches for Lorentz violation. Here, we explain that combining known elementary particle interactions with a Planck-scale preferred frame gives rise to Lorentz violation at the percent level, some 20 orders of magnitude higher than earlier estimates, unless the bare parameters of the theory are unnaturally strongly fine tuned. Therefore an important task is not just the improvement of the precision of searches for violations of Lorentz invariance, but also the search for theoretical mechanisms for automatically preserving Lorentz invariance.