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Showing papers by "National Autonomous University of Mexico published in 2014"


Journal ArticleDOI
Keith A. Olive1, Kaustubh Agashe2, Claude Amsler3, Mario Antonelli  +222 moreInstitutions (107)
TL;DR: The review as discussed by the authors summarizes much of particle physics and cosmology using data from previous editions, plus 3,283 new measurements from 899 Japers, including the recently discovered Higgs boson, leptons, quarks, mesons and baryons.
Abstract: The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,283 new measurements from 899 Japers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as heavy neutrinos, supersymmetric and technicolor particles, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as Supersymmetry, Extra Dimensions, Particle Detectors, Probability, and Statistics. Among the 112 reviews are many that are new or heavily revised including those on: Dark Energy, Higgs Boson Physics, Electroweak Model, Neutrino Cross Section Measurements, Monte Carlo Neutrino Generators, Top Quark, Dark Matter, Dynamical Electroweak Symmetry Breaking, Accelerator Physics of Colliders, High-Energy Collider Parameters, Big Bang Nucleosynthesis, Astrophysical Constants and Cosmological Parameters.

7,337 citations


Journal ArticleDOI
25 Jul 2014-Science
TL;DR: Defaunation is both a pervasive component of the planet’s sixth mass extinction and also a major driver of global ecological change.
Abstract: We live amid a global wave of anthropogenically driven biodiversity loss: species and population extirpations and, critically, declines in local species abundance. Particularly, human impacts on animal biodiversity are an under-recognized form of global environmental change. Among terrestrial vertebrates, 322 species have become extinct since 1500, and populations of the remaining species show 25% average decline in abundance. Invertebrate patterns are equally dire: 67% of monitored populations show 45% mean abundance decline. Such animal declines will cascade onto ecosystem functioning and human well-being. Much remains unknown about this “Anthropocene defaunation”; these knowledge gaps hinder our capacity to predict and limit defaunation impacts. Clearly, however, defaunation is both a pervasive component of the planet’s sixth mass extinction and also a major driver of global ecological change.

2,697 citations


Journal ArticleDOI
TL;DR: This work analyzed a global database of directly harvested trees at 58 sites, spanning a wide range of climatic conditions and vegetation types, and found a pantropical model incorporating wood density, trunk diameter, and the variable E outperformed previously published models without height.
Abstract: Terrestrial carbon stock mapping is important for the successful implementation of climate change mitigation policies. Its accuracy depends on the availability of reliable allometric models to infer oven-dry aboveground biomass of trees from census data. The degree of uncertainty associated with previously published pantropical aboveground biomass allometries is large. We analyzed a global database of directly harvested trees at 58 sites, spanning a wide range of climatic conditions and vegetation types (4004 trees ≥ 5 cm trunk diameter). When trunk diameter, total tree height, and wood specific gravity were included in the aboveground biomass model as covariates, a single model was found to hold across tropical vegetation types, with no detectable effect of region or environmental factors. The mean percent bias and variance of this model was only slightly higher than that of locally fitted models. Wood specific gravity was an important predictor of aboveground biomass, especially when including a much broader range of vegetation types than previous studies. The generic tree diameter-height relationship depended linearly on a bioclimatic stress variable E, which compounds indices of temperature variability, precipitation variability, and drought intensity. For cases in which total tree height is unavailable for aboveground biomass estimation, a pantropical model incorporating wood density, trunk diameter, and the variable E outperformed previously published models without height. However, to minimize bias, the development of locally derived diameter-height relationships is advised whenever possible. Both new allometric models should contribute to improve the accuracy of biomass assessment protocols in tropical vegetation types, and to advancing our understanding of architectural and evolutionary constraints on woody plant development.

1,750 citations


Journal ArticleDOI
TL;DR: MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) as mentioned in this paper employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers).
Abstract: We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 A at R ~ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (A–1 per 2'' fiber) at 23 AB mag arcsec–2, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M * 109 M ☉ using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.

1,104 citations


Book Chapter
01 Jan 2014
TL;DR: Agriculture, Forestry, and Other Land Use (AFOLU) is unique among the sectors considered in this volume, since the mitigation potential is derived from both an enhancement of removals of greenhouse gases (GHG), as well as reduction of emissions through management of land and livestock as discussed by the authors.
Abstract: Agriculture, Forestry, and Other Land Use (AFOLU) is unique among the sectors considered in this volume, since the mitigation potential is derived from both an enhancement of removals of greenhouse gases (GHG), as well as reduction of emissions through management of land and livestock (robust evidence; high agreement). The land provides food that feeds the Earth’s human population of ca. 7 billion, fibre for a variety of purposes, livelihoods for billions of people worldwide, and is a critical resource for sustainable development in many regions. Agriculture is frequently central to the livelihoods of many social groups, especially in developing countries where it often accounts for a significant share of production. In addition to food and fibre, the land provides a multitude of ecosystem services; climate change mitigation is just one of many that are vital to human well-being (robust evidence; high agreement). Mitigation options in the AFOLU sector, therefore, need to be assessed, as far as possible, for their potential impact on all other services provided by land. [Section 11.1]

964 citations


Journal ArticleDOI
M. Aguilar, D. Aisa1, Behcet Alpat, A. Alvino  +291 moreInstitutions (33)
TL;DR: In this paper, a precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1.GV to 1.8TV is presented based on 300 million events.
Abstract: A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.

783 citations


Journal ArticleDOI
TL;DR: The interplay between the PI3K/AKT/mTOR pathway and the autophagic process is complex and a more detailed examination of tissue from patients suffering neurodegenerative diseases and of animal and cellular models is needed.

763 citations


Journal ArticleDOI
25 Mar 2014-Zootaxa
TL;DR: A biogeographic regionalisation of the Neotropical region is proposed as a hierarchical classification of sub-regions, dominions, provinces and districts that seeks to provide universality, objectivity and stability, such that it can be applied when describing distributional areas of particular taxa or comparing different biogeographical analyses.
Abstract: A biogeographic regionalisation of the Neotropical region is proposed as a hierarchical classification of sub-regions, dominions, provinces and districts. This regionalisation is based on biogeographic analyses of terrestrial plant and animal taxa, and seeks to provide universality, objectivity and stability, such that it can be applied when describing distributional areas of particular taxa or comparing different biogeographic analyses. The Neotropical region is currently comprised of three sub-regions (Antillean, Brazilian and Chacoan), two transition zones (Mexican and South American), seven dominions (Mesoamerican, Pacific, Boreal Brazilian, Southwestern Amazonian, Southeastern Amazonian, Chacoan and Parana) and 53 provinces. For some of the latter, sub-provinces and districts are recognized. Complete synonymies and brief descriptions of the areas are provided, as well as the endemic taxa that diagnose the different provinces.

751 citations


Journal ArticleDOI
TL;DR: It is suggested that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges.
Abstract: Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal areas exhibiting shorter and longer timescales, respectively. On the basis of our findings, we suggest that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges.

742 citations


Journal ArticleDOI
TL;DR: The ALICE experiment at the CERN Large Hadron Collider as mentioned in this paper continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams.
Abstract: ALICE is the heavy-ion experiment at the CERN Large Hadron Collider. The experiment continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams. In this paper we describe the running environment and the data handling procedures, and discuss the performance of the ALICE detectors and analysis methods for various physics observables.

691 citations


Journal ArticleDOI
L. Accardo1, M. Aguilar, D. Aisa2, D. Aisa1  +308 moreInstitutions (28)
TL;DR: The new results show, for the first time, that above ∼200 GeV the positron fraction no longer exhibits an increase with energy.
Abstract: A precision measurement by AMS of the positron fraction in primary cosmic rays in the energy range from 0.5 to 500 GeV based on 10.9 million positron and electron events is presented. This measurement extends the energy range of our previous observation and increases its precision. The new results show, for the first time, that above ∼200 GeV the positron fraction no longer exhibits an increase with energy.

Journal ArticleDOI
TL;DR: In this article, the authors presented the most up-to-date X-ray luminosity function (XLF) and absorption function of Active Galactic Nuclei (AGNs) over the redshift range from 0 to 5, utilizing the largest, highly complete sample obtained from surveys performed with Swift/BAT, MAXI, ASCA, XMM-Newton, Chandra, and ROSAT.
Abstract: We present the most up-to-date X-ray luminosity function (XLF) and absorption function of Active Galactic Nuclei (AGNs) over the redshift range from 0 to 5, utilizing the largest, highly complete sample ever available obtained from surveys performed with Swift/BAT, MAXI, ASCA, XMM-Newton, Chandra, and ROSAT. The combined sample, including that of the Subaru/XMM-Newton Deep Survey, consists of 4039 detections in the soft (0.5--2 keV) and/or hard ($>2$ keV) band. We utilize a maximum likelihood method to reproduce the count-rate versus redshift distribution for each survey, by taking into account the evolution of the absorbed fraction, the contribution from Compton-thick (CTK) AGNs, and broad band spectra of AGNs including reflection components from tori based on the luminosity and redshift dependent unified scheme. We find that the shape of the XLF at $z \sim 1-3$ is significantly different from that in the local universe, for which the luminosity dependent density evolution model gives much better description than the luminosity and density evolution model. These results establish the standard population synthesis model of the X-Ray Background (XRB), which well reproduces the source counts, the observed fractions of CTK AGNs, and the spectrum of the hard XRB. The number ratio of CTK AGNs to the absorbed Compton-thin (CTN) AGNs is constrained to be $\approx$0.5--1.6 to produce the 20--50 keV XRB intensity within present uncertainties, by assuming that they follow the same evolution as CTN AGNs. The growth history of supermassive black holes is discussed based on the new AGN bolometric luminosity function.

Journal ArticleDOI
TL;DR: In this paper, the authors presented the largest and most homogeneous catalog of H ii regions and associations compiled so far, consisting of more than 7000 ionized regions, extracted from 306 galaxies observed by the CALIFA survey.
Abstract: We present the largest and most homogeneous catalog of H ii regions and associations compiled so far The catalog comprises more than 7000 ionized regions, extracted from 306 galaxies observed by the CALIFA survey We describe the procedures used to detect, select, and analyze the spectroscopic properties of these ionized regions In the current study we focus on characterizing of the radial gradient of the oxygen abundance in the ionized gas, based on the study of the deprojecteddistribution of H ii regions We found that all galaxies without clear evidence of an interaction present a common gradient in the oxygen abundance, with a characteristic slope of α_O/H = −01 dex/r_e between 03 and 2 disk effective radii (r_e), and a scatter compatible with random fluctuations around this value, when the gradient is normalized to the disk effective radius The slope is independent of morphology, the incidence of bars, absolute magnitude, or mass Only those galaxies with evidence of interactions and/or clear merging systems present a significantly shallower gradient, consistent with previous results The majority of the 94 galaxies with H ii regions detected beyond two disk effective radii present a flattening in the oxygen abundance The flattening is statistically significant We cannot provide a conclusive answer regarding the origin of this flattening However, our results indicate that its origin is most probably related to the secular evolution of galaxies Finally, we find a drop/truncation of the oxygen abundance in the inner regions for 26 of the galaxies All of them are non-interacting, mostly unbarred Sb/Sbc galaxies This feature is associated with a central star-forming ring, which suggests that both features are produced by radial gas flows induced by resonance processes Our result suggests that galaxy disks grow inside-out, with metal enrichment driven by the local star formation history and with a small variation galaxy-by-galaxy At a certain galactocentric distance, the oxygen abundance seems to be correlated well with the stellar mass density and total stellar mass of the galaxies, independently of other properties of the galaxies Other processes, such as radial mixing and inflows/outflows seem to have a limited effect on shaping of the radial distribution of oxygen abundances, although they are not ruled out

Journal ArticleDOI
M. Aguilar, D. Aisa1, A. Alvino, G. Ambrosi2  +276 moreInstitutions (35)
TL;DR: In this paper, the Alpha Magnetic Spectrometer on the International Space Station was used to measure the primary cosmic-ray electron flux in the range 0.5 to 700 GeV and the positron flux in a range of 0.1 to 500 GeV.
Abstract: Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray electron flux in the range 0.5 to 700 GeV and the positron flux in the range 0.5 to 500 GeV are presented. The electron flux and the positron flux each require a description beyond a single power-law spectrum. Both the electron flux and the positron flux change their behavior at ∼30 GeV but the fluxes are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the electron spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray electrons and positrons.

Journal ArticleDOI
A. L. Williams Amy1, A. L. Williams Amy2, S. B R Jacobs Suzanne2, Hortensia Moreno-Macías3, Alicia Huerta-Chagoya4, Claire Churchhouse2, Carla Marquez-Luna, María José Gómez-Vázquez5, N. P. Burtt Noël2, Carlos A. Aguilar-Salinas, Clicerio Gonzalez-Villalpando, Jose C. Florez1, Jose C. Florez2, Lorena Orozco, Teresa Tusié-Luna4, David Altshuler1, David Altshuler6, David Altshuler2, Stephan Ripke2, Stephan Ripke1, Alisa K. Manning2, Humberto García-Ortiz, Benjamin M. Neale1, Benjamin M. Neale2, David Reich2, David Reich1, Daniel O. Stram7, Juan Carlos Fernández-López, Sandra Romero-Hidalgo, Nick Patterson2, Christopher A. Haiman7, Irma Aguilar-Delfín, Angélica Martínez-Hernández, Federico Centeno-Cruz, Elvia Mendoza-Caamal, Cristina Revilla-Monsalve8, Sergio Islas-Andrade8, Emilio J. Cordova, Eunice Rodríguez-Arellano, Xavier Soberón, J. C. Florez Jose2, J. C. Florez Jose1, M. A. González-Villalpando María Elena, Brian E. Henderson7, Kristine R. Monroe7, Lynne R. Wilkens9, Laurence N. Kolonel9, Loic Le Marchand9, Laura Riba4, M. A. Ordóñez-Sánchez María Luisa, Rosario Rodríguez-Guillén, Ivette Cruz-Bautista, Maribel Rodríguez-Torres, Linda Liliana Muñoz-Hernandez, Tamara Sáenz, Donají Gómez, Ulices Alvirde, Robert C. Onofrio2, Wendy Brodeur2, Diane Gage2, Jacquelyn Murphy2, Jennifer Franklin2, Scott Mahan2, Kristin G. Ardlie2, Andrew Crenshaw2, Wendy Winckler2, Kay Prüfer10, Michael V. Shunkov, Susanna Sawyer10, Udo Stenzel10, Janet Kelso10, Monkol Lek2, Monkol Lek1, Sriram Sankararaman2, Sriram Sankararaman1, Daniel G. MacArthur2, Daniel G. MacArthur1, A.P. Derevianko, Svante Pääbo10, Suzanne B.R. Jacobs2, Shuba Gopal2, James A. Grammatikos2, Ian Smith2, Kevin Bullock2, Amy Deik2, Amanda Souza2, Kerry A. Pierce2, Clary B. Clish2, Timothy Fennell2, Yossi Farjoun2, Stacey Gabriel2, Myron D. Gross11, Mark A. Pereira11, Mark Seielstad12, Woon-Puay Koh13, E. Shyong Tai13, Jason Flannick2, Jason Flannick1, Pierre Fontanillas2, Andrew D. Morris14, Tanya M. Teslovich15, Gil Atzmon16, John Blangero17, Donald W. Bowden18, John C. Chambers19, John C. Chambers20, Yoon Shin Cho21, Ravindranath Duggirala17, Benjamin Glaser22, Benjamin Glaser23, Craig L. Hanis24, Jaspal S. Kooner19, Jaspal S. Kooner20, Markku Laakso25, Jong-Young Lee, Yik Ying Teo13, Yik Ying Teo26, James G. Wilson27, Sobha Puppala17, Vidya S. Farook17, Farook Thameem28, Hanna E. Abboud28, Ralph A. DeFronzo28, Christopher P. Jenkinson28, Donna M. Lehman28, Joanne E. Curran17, Maria L. Cortes2, C. González-Villalpando Clicerio, L. Orozco Lorena 
06 Feb 2014-Nature
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Abstract: Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles. Here we analysed 9.2 million single nucleotide polymorphisms (SNPs) in each of 8,214 Mexicans and other Latin Americans: 3,848 with type 2 diabetes and 4,366 non-diabetic controls. In addition to replicating previous findings, we identified a novel locus associated with type 2 diabetes at genome-wide significance spanning the solute carriers SLC16A11 and SLC16A13 (P = 3.9 × 10(-13); odds ratio (OR) = 1.29). The association was stronger in younger, leaner people with type 2 diabetes, and replicated in independent samples (P = 1.1 × 10(-4); OR = 1.20). The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in European and African samples. Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals. The SLC16A11 messenger RNA is expressed in liver, and V5-tagged SLC16A11 protein localizes to the endoplasmic reticulum. Expression of SLC16A11 in heterologous cells alters lipid metabolism, most notably causing an increase in intracellular triacylglycerol levels. Despite type 2 diabetes having been well studied by genome-wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Journal ArticleDOI
TL;DR: SURPI is described, a computational pipeline for pathogen identification from complex metagenomic NGS data generated from clinical samples, and use of the pipeline is demonstrated in the analysis of 237 clinical samples comprising more than 1.1 billion sequences.
Abstract: Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen detection in the clinical microbiology laboratory and have numerous applications for public health surveillance, outbreak investigation, and the diagnosis of infectious diseases. However, practical deployment of the technology is hindered by the bioinformatics challenge of analyzing results accurately and in a clinically relevant timeframe. Here we describe SURPI ("sequence-based ultrarapid pathogen identification"), a computational pipeline for pathogen identification from complex metagenomic NGS data generated from clinical samples, and demonstrate use of the pipeline in the analysis of 237 clinical samples comprising more than 1.1 billion sequences. Deployable on both cloud-based and standalone servers, SURPI leverages two state-of-the-art aligners for accelerated analyses, SNAP and RAPSearch, which are as accurate as existing bioinformatics tools but orders of magnitude faster in performance. In fast mode, SURPI detects viruses and bacteria by scanning data sets of 7-500 million reads in 11 min to 5 h, while in comprehensive mode, all known microorganisms are identified, followed by de novo assembly and protein homology searches for divergent viruses in 50 min to 16 h. SURPI has also directly contributed to real-time microbial diagnosis in acutely ill patients, underscoring its potential key role in the development of unbiased NGS-based clinical assays in infectious diseases that demand rapid turnaround times.

Journal ArticleDOI
TL;DR: The task force defined the treatment target for SpA as remission or, alternatively, low disease activity, being aware that the evidence base is not strong and needs to be expanded by future research.
Abstract: Background Therapeutic targets have been defined for diseases like diabetes, hypertension or rheumatoid arthritis and adhering to them has improved outcomes. Such targets are just emerging for spondyloarthritis (SpA). Objective To define the treatment target for SpA including ankylosing spondylitis and psoriatic arthritis (PsA) and develop recommendations for achieving the target, including a treat-to-target management strategy. Methods Based on results of a systematic literature review and expert opinion, a task force of expert physicians and patients developed recommendations which were broadly discussed and voted upon in a Delphi-like process. Level of evidence, grade and strength of the recommendations were derived by respective means. The commonalities between axial SpA, peripheral SpA and PsA were discussed in detail. Results Although the literature review did not reveal trials comparing a treat-to-target approach with another or no strategy, it provided indirect evidence regarding an optimised approach to therapy that facilitated the development of recommendations. The group agreed on 5 overarching principles and 11 recommendations; 9 of these recommendations related commonly to the whole spectrum of SpA and PsA, and only 2 were designed separately for axial SpA, peripheral SpA and PsA. The main treatment target, which should be based on a shared decision with the patient, was defined as remission, with the alternative target of low disease activity. Follow-up examinations at regular intervals that depend on the patient9s status should safeguard the evolution of disease activity towards the targeted goal. Additional recommendations relate to extra-articular and extramusculoskeletal aspects and other important factors, such as comorbidity. While the level of evidence was generally quite low, the mean strength of recommendation was 9–10 (10: maximum agreement) for all recommendations. A research agenda was formulated. Conclusions The task force defined the treatment target as remission or, alternatively, low disease activity, being aware that the evidence base is not strong and needs to be expanded by future research. These recommendations can inform the various stakeholders about expert opinion that aims for reaching optimal outcomes of SpA.

Journal ArticleDOI
13 Jun 2014-Science
TL;DR: Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.
Abstract: Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.

Journal ArticleDOI
TL;DR: In this article, the authors used InSAR time-series analysis of ALOS data to resolve land subsidence in the entire central Mexico region, including 17 cities, and found that groundwater extraction mainly for agricultural and urban activities is the main cause of land subsiding.

Journal ArticleDOI
A. Aab1, P. Abreu2, P. Abreu3, Marco Aglietta4  +511 moreInstitutions (70)
TL;DR: In this article, a study of the distributions of the depth of maximum, X-max, of extensive air-shower profiles with energies above 10(17.8) eV was performed with the fluorescence telescopes of the Pierre Auger Observatory.
Abstract: We report a study of the distributions of the depth of maximum, X-max, of extensive air-shower profiles with energies above 10(17.8) eV as observed with the fluorescence telescopes of the Pierre Auger Observatory. The analysis method for selecting a data sample with minimal sampling bias is described in detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss the detector acceptance and the resolution of the X-max measurement and provide parametrizations thereof as a function of energy. The energy dependence of the mean and standard deviation of the X-max distributions are compared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean and variance of the logarithmic mass distribution at the top of the atmosphere.

Journal ArticleDOI
TL;DR: The Coordinated Synoptic Investigation of NGC 2264 (CSI 2264) as discussed by the authors was a 30-day multi-wavelength photometric monitoring campaign on more than 1000 young star members using 16 telescopes.
Abstract: We present the Coordinated Synoptic Investigation of NGC 2264, a continuous 30 day multi-wavelength photometric monitoring campaign on more than 1000 young cluster members using 16 telescopes. The unprecedented combination of multi-wavelength, high-precision, high-cadence, and long-duration data opens a new window into the time domain behavior of young stellar objects. Here we provide an overview of the observations, focusing on results from Spitzer and CoRoT. The highlight of this work is detailed analysis of 162 classical T Tauri stars for which we can probe optical and mid-infrared flux variations to 1% amplitudes and sub-hour timescales. We present a morphological variability census and then use metrics of periodicity, stochasticity, and symmetry to statistically separate the light curves into seven distinct classes, which we suggest represent different physical processes and geometric effects. We provide distributions of the characteristic timescales and amplitudes and assess the fractional representation within each class. The largest category (>20%) are optical "dippers" with discrete fading events lasting ~1-5 days. The degree of correlation between the optical and infrared light curves is positive but weak; notably, the independently assigned optical and infrared morphology classes tend to be different for the same object. Assessment of flux variation behavior with respect to (circum)stellar properties reveals correlations of variability parameters with Hα emission and with effective temperature. Overall, our results point to multiple origins of young star variability, including circumstellar obscuration events, hot spots on the star and/or disk, accretion bursts, and rapid structural changes in the inner disk.

Journal ArticleDOI
TL;DR: In this paper, the authors presented the most up-to-date X-ray luminosity function (XLF) and absorption function of Active Galactic Nuclei (AGNs) over the redshift range from 0 to 5, utilizing the largest, highly complete sample obtained from surveys performed with Swift/BAT, MAXI, ASCA, XMM-Newton, Chandra, and ROSAT.
Abstract: We present the most up-to-date X-ray luminosity function (XLF) and absorption function of Active Galactic Nuclei (AGNs) over the redshift range from 0 to 5, utilizing the largest, highly complete sample ever available obtained from surveys performed with Swift/BAT, MAXI, ASCA, XMM-Newton, Chandra, and ROSAT. The combined sample, including that of the Subaru/XMM-Newton Deep Survey, consists of 4039 detections in the soft (0.5--2 keV) and/or hard ($>2$ keV) band. We utilize a maximum likelihood method to reproduce the count-rate versus redshift distribution for each survey, by taking into account the evolution of the absorbed fraction, the contribution from Compton-thick (CTK) AGNs, and broad band spectra of AGNs including reflection components from tori based on the luminosity and redshift dependent unified scheme. We find that the shape of the XLF at $z \sim 1-3$ is significantly different from that in the local universe, for which the luminosity dependent density evolution model gives much better description than the luminosity and density evolution model. These results establish the standard population synthesis model of the X-Ray Background (XRB), which well reproduces the source counts, the observed fractions of CTK AGNs, and the spectrum of the hard XRB. The number ratio of CTK AGNs to the absorbed Compton-thin (CTN) AGNs is constrained to be $\approx$0.5--1.6 to produce the 20--50 keV XRB intensity within present uncertainties, by assuming that they follow the same evolution as CTN AGNs. The growth history of supermassive black holes is discussed based on the new AGN bolometric luminosity function.

Journal ArticleDOI
TL;DR: Recent knowledge gained from PLK crystal structures, evolution and interacting molecules offers important insights into the mechanisms that underlie their regulation and activity, and suggests novel functions unrelated to cell cycle control for this family of kinases.
Abstract: Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo major changes in abundance, activity, localization and structure at different stages of the cell cycle. They interact with other proteins in a tightly controlled spatiotemporal manner as part of a network that coordinates key cell cycle events. Their essential roles are highlighted by the fact that alterations in PLK function are associated with cancers and other diseases. Recent knowledge gained from PLK crystal structures, evolution and interacting molecules offers important insights into the mechanisms that underlie their regulation and activity, and suggests novel functions unrelated to cell cycle control for this family of kinases.

Journal ArticleDOI
TL;DR: The first systematic review of pollination syndromes that quantitatively tests whether the most effective pollinators for a species can be inferred from suites of floral traits for 417 plant species supports the syndrome concept.
Abstract: The idea of pollination syndromes has been largely discussed but no formal quantitative evaluation has yet been conducted across angiosperms. We present the first systematic review of pollination syndromes that quantitatively tests whether the most effective pollinators for a species can be inferred from suites of floral traits for 417 plant species. Our results support the syndrome concept, indicating that convergent floral evolution is driven by adaptation to the most effective pollinator group. The predictability of pollination syndromes is greater in pollinator-dependent species and in plants from tropical regions. Many plant species also have secondary pollinators that generally correspond to the ancestral pollinators documented in evolutionary studies. We discuss the utility and limitations of pollination syndromes and the role of secondary pollinators to understand floral ecology and evolution.

Journal ArticleDOI
TL;DR: The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America.
Abstract: The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, Mexico and Peru). These individuals were also characterized for a range of physical appearance traits and for self-perception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry.

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TL;DR: Every reaction stage has a family of subsequent structures that are characterized not solely by their phenomenological behavior but also by informational properties of their electronic density distribution (localizability, order, uniformity).
Abstract: The course of the Diels-Alder reactions of cyclopentadiene and maleic anhydride were studied. Two reaction paths were modelled: endo- and exo-selective paths. All structures within the transient region were characterized and analyzed by means of geometrical descriptors, physicochemical parameters and information-theoretical measures in order to observe the linkage between chemical behavior and the carriage of information. We have shown that the information-theoretical characterization of the chemical course of the reaction is in complete agreement with its phenomenological behavior in passing from reactants to products. In addition, we were able to detect the main differences between the two reaction mechanisms. This type of informational analysis serves to provide tools to help understand the chemical reactivity of the two simplest Diels-Alder reactions, which permits the establishment of a connection between the quantum changes that molecular systems exert along reaction coordinates and standard physicochemical phenomenology. In the present study, we have shown that every reaction stage has a family of subsequent structures that are characterized not solely by their phenomenological behavior but also by informational properties of their electronic density distribution (localizability, order, uniformity). Moreover, we were able to describe the main differences between endo-adduct and exo-adduct pathways. With the advent of new experimental techniques, it is in principle possible to observe the structural changes in the transient regions of chemical reactions. Indeed, through this work we have provided the theoretical concepts needed to unveil the concurrent processes associated with chemical reactions.

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TL;DR: In this paper, the effects of biodiversity change on selected ecosystem services are evaluated and the authors suggest ways to further understand the links between biodiversity change and ecosystem services, including forage, timber, fisheries, climate regulation, agricultural pest control, and water quality.
Abstract: Understanding when biodiversity conservation and ecosystem-service maintenance are compatible is needed within the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES). Here, we evaluate current understanding and uncertainties of the effects of biodiversity change on selected ecosystem services and suggest ways to further understand the links between biodiversity change and ecosystem services. We reviewed experiments, observations, and syntheses on the effects of species richness on six ecosystem services: forage, timber, fisheries, climate regulation, agricultural pest control, and water quality. Establishing a direct link from biodiversity to ecosystem-service provision has often been precluded by limited data (i.e., the amount, consistency, or generality of the data) and a mismatch between the variables measured and the final ecosystem service that is relevant to stakeholders. We suggest that encompassing syntheses and a network of interdisciplinary experiments under realistic conditions could fill these gaps and could inform the outcomes of alternative management and policy scenarios within IPBES.

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TL;DR: Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper, lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.

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24 Jun 2014-Forests
TL;DR: In this article, the feasibility of using small, low-cost drones (i.e., remotely piloted aerial vehicles) in community-based forest monitoring (CBFM) programs was assessed.
Abstract: Data gathered through community-based forest monitoring (CBFM) programs may be as accurate as those gathered by professional scientists, but acquired at a much lower cost and capable of providing more detailed data about the occurrence, extent and drivers of forest loss, degradation and regrowth at the community scale. In addition, CBFM enables greater survey repeatability. Therefore, CBFM should be a fundamental component of national forest monitoring systems and programs to measure, report and verify (MRV) REDD+ activities. To contribute to the development of more effective approaches to CBFM, in this paper we assess: (1) the feasibility of using small, low-cost drones (i.e., remotely piloted aerial vehicles) in CBFM programs; (2) their potential advantages and disadvantages for communities, partner organizations and forest data end-users; and (3) to what extent their utilization, coupled with ground surveys and local ecological knowledge, would improve tropical forest monitoring. To do so, we reviewed the existing literature regarding environmental applications of drones, including forest monitoring, and drew on our own firsthand experience flying small drones to map and monitor tropical forests and training people to operate them. We believe that the utilization of small drones can enhance CBFM and that this approach is feasible in many locations throughout the tropics if some degree of external assistance and funding is provided to communities. We suggest that the use of small drones can help tropical communities to better manage and conserve their forests whilst benefiting partner organizations, governments and forest data end-users, particularly those engaged in forestry, biodiversity conservation and climate change mitigation projects such as REDD+.

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TL;DR: In this article, the authors studied the incidence of nuclear obscuration on a complete sample of 1310 AGN selected on the basis of their rest-frame 2.10 keV X-ray flux from the XM M-COSMOS survey, in the redshift range 0.3 < z < 3.5.
Abstract: We study the incidence of nuclear obscuration on a complete sample of 1310 AGN selected on the basis of their rest-frame 2‐10 keV X-ray flux from the XM M-COSMOS survey, in the redshift range 0.3 < z < 3.5. We classify the AGN as obscured or un-obscured on the basis of either the optical spectral properties and the over all SED or the shape of the X-ray spectrum. The two classifications agree in about 70% of the ob jects, and the remaining 30% can be further subdivided into two distinct classes: at low l uminosities X-ray un-obscured AGN do not always show signs of broad lines or blue/UV continuum emission in their optical spectra, most likely due to galaxy dilution effects; a t high luminosities broad line AGN may have absorbed X-ray spectra, which hints at an increased incidence of small-scale (subparsec) dust-free obscuration. We confirm that the fraction of obscured AGN is a decreasing function of the intrinsic X-ray luminosity, while the incid ence of absorption shows significant evolution only for the most luminous AGN, which appear to be more commonly obscured at higher redshift. We find no significant difference between th e mean stellar masses and star formation rates of obscured and un-obscured AGN hosts. We conclude that the physical state of the medium responsible for obscuration in AGN is complex, and mainly determined by the radiation environment (nuclear luminosity) in a small region enclosed within the gravitational sphere of influence of the central black hole, but is la rgely insensitive to the wider scale galactic conditions.