National Autonomous University of Mexico

About: National Autonomous University of Mexico is a education organization based out in Mexico City, Distrito Federal, Mexico. It is known for research contribution in the topics: Population & Galaxy. The organization has 72868 authors who have published 127797 publications receiving 2285543 citations. The organization is also known as: UNAM & Universidad Nacional Autónoma de México.

Photoevaporation of Cosmological Minihalos during Reionization

Abstract: We present the first gas dynamical simulations of the photoevaporation of cosmological minihalos overtaken by the ionization fronts which swept through the IGM during reionization in a LCDM universe, including the effects of radiative transfer. We demonstrate the phenomenon of I-front trapping inside minihalos, in which the weak, R-type fronts which traveled supersonically across the IGM decelerated when they encountered the dense, neutral gas inside minihalos, becoming D-type I-fronts, preceded by shock waves. For a minihalo with virial temperature T_vir < 10^4 K, the I-front gradually burned its way through the minihalo which trapped it, removing all of its baryonic gas by causing a supersonic, evaporative wind to blow backwards into the IGM, away from the exposed layers of minihalo gas just behind the advancing I-front. Such hitherto neglected feedback effects were widespread during reionization. N-body simulations and analytical estimates of halo formation suggest that sub-kpc minihalos such as these, with T_vir < 10^4 K, were so common as to cover the sky around larger-mass source halos and possibly dominate the absorption of ionizing photons. This means that previous estimates of the number of ionizing photons per H atom required to complete reionization which neglected this effect may be too low. Regardless of their effect on the progress of reionization, however, the minihalos were so abundant that random lines of sight thru the high-z universe should encounter many of them, which suggests that it may be possible to observe the processes described here in the absorption spectra of distant sources.

Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus

Abstract: Background: Severe neurological involvement in systemic lupus erythematosus (NPSLE) is one of the most dreadful complications of the disease. Objective: To identify the best drug, dose, and treatment. Patients and methods: The study was a controlled clinical trial at two tertiary care centres of patients with SLE according to the ACR criteria, with incident (no more than 15 days) onset of severe NP manifestations such as seizures, optic neuritis, peripheral or cranial neuropathy, coma, brainstem disease, or transverse myelitis. Induction treatment with 3 g of IV methylprednisolone (MP) followed by either IV monthly cyclophosphamide (Cy) versus IV MP bimonthly every 4 months for 1 year and then IV Cy or IV MP every 3 months for another year. The primary end point was response to treatment: at least 20% improvement from basal conditions on clinical, laboratory, or specific neurological testing variables. Results: Overall, a response rate of 75% was observed. Of the 32 patients studied, 18/19 receiving Cy and 7/13 receiving MP responded to treatment (p<0.03). Conclusions: Cy seems to be more effective than MP in the treatment of acute, severe NPSLE.

Transancestral mapping and genetic load in systemic lupus erythematosus

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P<5 × 10-8), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.