National Autonomous University of Nicaragua

About: National Autonomous University of Nicaragua is a education organization based out in Managua, Nicaragua. It is known for research contribution in the topics: Population & Public health. The organization has 775 authors who have published 715 publications receiving 9791 citations.

Prevalence of Diabetes and Intermediate Hyperglycemia Among Adults From the First Multinational Study of Noncommunicable Diseases in Six Central American Countries: The Central America Diabetes Initiative (CAMDI)

Abstract: OBJECTIVE The increasing burdens of obesity and diabetes are two of the most prominent threats to the health of populations of developed and developing countries alike. The Central America Diabetes Initiative (CAMDI) is the first study to examine the prevalence of diabetes in Central America. RESEARCH DESIGN AND METHODS The CAMDI survey was a cross-sectional survey based on a probabilistic sample of the noninstitutionalized population of five Central American populations conducted between 2003 and 2006. The total sample population was 10,822, of whom 7,234 (67%) underwent anthropometry measurement and a fasting blood glucose or 2-h oral glucose tolerance test. RESULTS The total prevalence of diabetes was 8.5%, but was higher in Belize (12.9%) and lower in Honduras (5.4%). Of the screened population, 18.6% had impaired glucose tolerance/impaired fasting glucose. CONCLUSIONS As this population ages, the prevalence of diabetes is likely to continue to rise in a dramatic and devastating manner. Preventive strategies must be quickly introduced.

Dental plaque, preventive care, and tooth brushing associated with dental caries in primary teeth in schoolchildren ages 6-9 years of Leon, Nicaragua

Abstract: BACKGROUND Our study aimed to evaluate the effect of various risk indicators for dental caries on primary teeth of Nicaraguan children (from Leon, Nicaragua) ages 6 to 9, using the negative binomial regression model. MATERIAL/METHODS A cross-sectional study was carried out to collect clinical, demographic, socioeconomic, and behavioral data from 794 schoolchildren ages 6 to 9 years, randomly selected from 25 schools in the city of Leon, Nicaragua. Clinical examinations for dental caries (dmft index) were performed by 2 trained and standardized examiners. Socio-demographic, socioeconomic, and behavioral data were self-reported using questionnaires. Multivariate negative binomial regression (NBR) analysis was used. RESULTS Mean age was 7.49 ± 1.12 years. Boys accounted for 50.1% of the sample. Mean dmft was 3.54 ± 3.13 and caries prevalence (dmft >0) was 77.6%. In the NBR multivariate model (p<0.05), for each year of age, the expected mean dmft decreased by 7.5%. Brushing teeth at least once a day and having received preventive dental care in the last year before data collection were associated with declines in the expected mean dmft by 19.5% and 69.6%, respectively. Presence of dental plaque increased the expected mean dmft by 395.5%. CONCLUSIONS The proportion of students with caries in this sample was high. We found associations between dental caries in the primary dentition and dental plaque, brushing teeth at least once a day, and having received preventive dental care. To improve oral health, school programs and/or age-appropriate interventions need to be developed based on the specific profile of caries experience and the associated risk indicators.

J-PLUS : on the identification of new cluster members in the double galaxy cluster A2589 and A2593 using PDFs

Abstract: Aims. We aim to use multiband imaging from the Phase-3 Verification Data of the J-PLUS survey to derive accurate photometric redshifts (photo-z) and look for potential new members in the surroundings of the nearby galaxy clusters A2589 (z = 0.0414) & A2593 (z = 0.0440), using redshift probability distribution functions (PDFs). The ultimate goal is to demonstrate the usefulness of a 12-band filter system in the study of largescale structure in the local Universe.Methods. We present an optimized pipeline for the estimation of photometric redshifts in clusters of galaxies. This pipeline includes a PSF-corrected photometry, specific photometric apertures capable of enhancing the integrated signal in the bluest filters, a careful recalibration of the photometric uncertainties and accurate upper-limit estimations for faint detections. To foresee the expected precision of our photo-z beyond the spectroscopic sample, we designed a set of simulations in which real cluster galaxies are modeled and reinjected inside the images at different signal-to-noise ratio (S/N) levels, recomputing their photometry and photo-z estimates.Results. We tested our photo-z pipeline with a sample of 296 spectroscopically confirmed cluster members with an averaged magnitude of ⟨r ⟩ = 16.6 and redshift ⟨z ⟩ = 0.041. The combination of seven narrow and five broadband filters with a typical photometric-depth of r ~ 21.5 provides δ z /(1 + z ) = 0.01 photo-z estimates. A precision of δ z /(1 + z ) = 0.005 is obtained for the 177 galaxies brighter than magnitude r z /(1 + z ) = 0.02 and δ z /(1 + z ) = 0.03 is expected at magnitudes ⟨r ⟩ = 18 and ⟨r ⟩ = 22, respectively. Complementarily, we used SDSS/DR12 data to derive photo-z estimates for the same galaxy sample. This exercise demonstrates that the wavelength-resolution of the J-PLUS data can double the precision achieved by SDSS data for galaxies with a high S/N. Based on the Bayesian membership analysis carried out in this work, we find as much as 170 new candidates across the entire field (~5 deg2 ). The spatial distribution of these galaxies may suggest an overlap between the systems with no evidence of a clear filamentary structure connecting the clusters. This result is supported by X-ray Rosat All-Sky Survey observations suggesting that a hypothetical filament may have low density contrast on diffuse warm gas.Conclusions. We prove that the addition of the seven narrow-band filters make the J-PLUS data deeper in terms of photo-z-depth than other surveys of a similar photometric-depth but using only five broadbands. These preliminary results show the potential of J-PLUS data to revisit membership of groups and clusters from nearby galaxies, important for the determination of luminosity and mass functions and environmental studies at the intermediate and low-mass regime.

Efficacy of a dengue vaccine candidate (TAK-003) in healthy children and adolescents two years after vaccination.

Abstract: Background Takeda's dengue vaccine is under evaluation in an ongoing Phase 3 efficacy study; we present an update after 2 years. Methods 20,099 children (4-16 years old) were randomized to receive two doses of TAK-003 or placebo three months apart and are under long-term febrile surveillance to detect dengue by serotype-specific RT-PCR. (NCT02747927). Results Cumulative efficacy against dengue over ~27 months since first dose was 72.7% (95% CI: 67.1 - 77.3), which included efficacy of 67.0% (95% CI: 53.6 - 76.5) in dengue-naive and 89.2% (82.4 - 93.3) against hospitalized dengue. In the second year after vaccination, a decline in efficacy was observed [56.2% (42.3 - 66.8)] with the largest decline in 4 - 5 year-old children [24.5% (-34.2 - 57.5)]; efficacy was 60.6% (43.8 - 72.4) in 6 - 11 year and 71.2% (41.0 - 85.9) in 12 - 16 year age groups. As TAK-003 efficacy varies by serotype, changes in serotype dominance partially contributed to the efficacy differences in year by year analysis. No related serious adverse events occurred during the second year. Conclusion TAK-003 demonstrated continued benefit independent of baseline serostatus in reducing dengue with some decline in efficacy during the second year. Three-year data will be important to see if efficacy stabilizes or declines further.

Unsuspected leptospirosis is a cause of acute febrile illness in Nicaragua.

Abstract: Background Epidemic severe leptospirosis was recognized in Nicaragua in 1995, but unrecognized epidemic and endemic disease remains unstudied. Methodology/Principal Findings To determine the burden of and risk factors associated with symptomatic leptospirosis in Nicaragua, we prospectively studied patients presenting with fever at a large teaching hospital. Epidemiologic and clinical features were systematically recorded, and paired sera tested by IgM-ELISA to identify patients with probable and possible acute leptospirosis. Microscopic Agglutination Test and PCR were used to confirm acute leptospirosis. Among 704 patients with paired sera tested by MAT, 44 had acute leptospirosis. Patients with acute leptospirosis were more likely to present during rainy months and to report rural residence and fresh water exposure. The sensitivity of clinical impression and acute-phase IgM detected by ELISA were poor. Conclusions/Significance Leptospirosis is a common (6.3%) but unrecognized cause of acute febrile illness in Nicaragua. Rapid point-of-care tests to support early diagnosis and treatment as well as tests to support population-based studies to delineate the epidemiology, incidence, and clinical spectrum of leptospirosis, both ideally pathogen-based, are needed.