National Autonomous University of Nicaragua

About: National Autonomous University of Nicaragua is a education organization based out in Managua, Nicaragua. It is known for research contribution in the topics: Population & Public health. The organization has 775 authors who have published 715 publications receiving 9791 citations.

Near-Complete Genome Sequences of Several New Norovirus Genogroup II Genotypes.

Abstract: We report here the near-complete genome sequences of 13 norovirus strains detected in stool samples from patients with acute gastroenteritis from Bangladesh, Ecuador, Guatemala, Peru, Nicaragua, and the United States that are classified into one existing (genotype II.22 [GII.22]), 3 novel (GII.23, GII.24 and GII.25), and 3 tentative novel (GII.NA1, GII.NA2, and GII.NA3) genotypes.

Geophysical characterization of the Leon-Chinandega aquifer, Nicaragua

Abstract: Electrical geophysical surveys in the mode of vertical electrical soundings (VES) and continuous vertical electrical soundings (CVES) were conducted in the Leon-Chinandega plains, northwestern Nicaragua, in order to obtain detailed information about the geometry of the different hydrogeological layers in the aquifer and depth to the basement. A total of 51 VES were carried out within the plains. The results show a complex structure towards the north east of the area, and the southwestern part of the plains presents a smoother stratification. The geoelectrical measurements and borehole information indicate that the basement topography is characterized by hills and deep valleys with highly variable basement depths. Fifty CVES where done in a smaller area in the center of the plain. The resistivity data yielded considerable information revealing the existence of two main geo-electrical units. The combined interpretation of geological and geophysical data shows an environment typical of sedimentary volcanic coastal plains. The information collected during this investigation provides valuable data for estimating the fresh-water resources of the Leon-Chinandega aquifer system and for development of a groundwater management plan.

High-resolution HLA allele and haplotype frequencies in majority and minority populations of Costa Rica and Nicaragua: Differential admixture proportions in neighboring countries.

Abstract: The HLA system shows the most extensive polymorphism in the human genome. Allelic and haplotypic frequencies of HLA genes vary dramatically across human populations. Due to a complex history of migration, populations in Latin America show a broad variety of admixture proportions, usually varying not only between countries, but also within countries. Knowledge of HLA allele and haplotype frequencies is essential for medical fields such as transplantation, but also serves as a means to assess genetic diversity and ancestry in human populations. Here, we have determined high-resolution HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies in a sample of 713 healthy subjects from three Mestizo populations, one population of African descent, and Amerindians of five different groups from Costa Rica and Nicaragua and compared their profiles to a large set of indigenous populations from Iberia, Sub-Saharan Africa, and the Americas. Our results show a great degree of allelic and haplotypic diversity within and across these populations, with most extended haplotypes being private. Mestizo populations show alleles and haplotypes of putative European, Amerindian, and Sub-Saharan African origin, albeit with differential proportions. Despite some degree of gene flow, Amerindians and Afro-descendants show great similarity to other Amerindian and West African populations, respectively. This is the first comprehensive study reporting high-resolution HLA diversity in Central America, and its results will shed light into the genetic history of this region while also supporting the development of medical programs for organ and stem cell transplantation.