Institution
National Autonomous University of Nicaragua
Education•Managua, Nicaragua•
About: National Autonomous University of Nicaragua is a education organization based out in Managua, Nicaragua. It is known for research contribution in the topics: Population & Public health. The organization has 775 authors who have published 715 publications receiving 9791 citations.
Topics: Population, Public health, Kidney disease, Rotavirus, Health care
Papers published on a yearly basis
Papers
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TL;DR: This paper used rotavirus as a guide, elucidating determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates.
Abstract: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.
8 citations
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TL;DR: The results suggest that Tsol-p27 can be a suitable candidate for diagnosis of human NCC, not only in Central America but also in sub-Saharan Africa.
8 citations
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TL;DR: To protect against diarrhoeal cases associated with this E. coli pathotype in León, Nicaragua, an ETEC vaccine that effectively targets the archeotype CFA/I of the class 5 fimbrial family would be the most effective in this setting.
Abstract: Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of diarrhoea among young children in developing countries. ETEC vaccines offer promise in reducing the burden of ETEC disease, but the development of these vaccines relies on the characterization of ETEC isolates from a variety of settings. To best reflect the full spectrum of ETEC disease in Leon, Nicaragua, the aim of this study was to characterize ETEC strains isolated from children with diarrhoea attending different settings (hospital, primary care clinics and in the community) and children from different age groups. We characterized ETEC isolates in terms of their colonization factors (CFs) and enterotoxins, and determined whether these factors varied with setting and age group. Diarrhoeal stool samples were obtained from children under the age of 60 months from: (1) the regional public hospital, (2) four public primary care clinics, and (3) a population-based cohort. In total, 58 ETEC-positive isolates were analysed by multiplex-PCR assays for the identification of CFs (CS1, CS2, CS3, CS4, CS5, CS6, CS7, CS8, CS12, CS13, CS14, CS15, CS17, CS18, CS19, CS20, CS21, CS22 and CFA/I), and enterotoxins [heat-labile toxin (LT) and heat-stable variants STh and STp]. The frequency of CFs and enterotoxins was compared among the three settings and for different age groups, using Fisher’s exact test or a χ2 test. At least one CF was detected among one-half of samples; CS19 was detected among all strains in which a CF was identified, either alone or in combination with another CF. Among all CFs detected, 91.7 % were identified as members of the class 5 fimbrial family. CFs were detected more commonly among samples from infants captured in the health facility setting compared with the community setting. Overall, LT was detected among 67.2 % of samples, STh was detected among 20.7 % and both enterotoxins were detected among 12.1 %. The enterotoxin STh was detected more commonly among cases in the community, whilst a combination of STh and LT was detected more commonly among cases treated in health facilities. Our results suggest that, to protect against diarrhoeal cases associated with this E. coli pathotype in Leon, Nicaragua, an ETEC vaccine that effectively targets the archeotype CFA/I of the class 5 fimbrial family would be the most effective in this setting.
8 citations
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TL;DR: The 2-year programme was the largest mobilization of public and private resources for pest management ever undertaken in Nicaragua, and gives practical evidence that suppression of between-season boll weevil populations can form the basis for more profitable control of this key pest in the commercial cotton season.
7 citations
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University of Extremadura1, Universidad San Francisco de Quito2, Instituto Politécnico Nacional3, Karolinska Institutet4, University of Mumbai5, Amrita Vishwa Vidyapeetham6, Universidad Autónoma de Yucatán7, National Autonomous University of Nicaragua8, University of Beira Interior9, Universidade Federal de Minas Gerais10, National Autonomous University of Mexico11, Pontifical Catholic University of Argentina12, World Health Organization13
TL;DR: The main result of session 1 was that the pharmacogenetics-related ancestry of the population should be considered when designing clinical studies in RLSs, and the social aspects represent the largest proportion of the challenges and opportunities.
7 citations
Authors
Showing all 782 results
Name | H-index | Papers | Citations |
---|---|---|---|
José A. G. Agúndez | 49 | 270 | 8893 |
Adrián LLerena | 43 | 226 | 6276 |
Julio Benítez | 40 | 108 | 4357 |
Noemí Castro | 30 | 98 | 2183 |
Carolina González | 21 | 63 | 1395 |
Filemon Bucardo | 21 | 54 | 1507 |
Rodolfo Peña | 21 | 39 | 2792 |
Juan Jovel | 20 | 58 | 2235 |
Eliette Valladares | 19 | 35 | 3048 |
Margarita Paniagua | 17 | 24 | 935 |
Carlos M. Vilas | 16 | 124 | 982 |
Aurora Aragón | 16 | 33 | 1073 |
Michael H. Carstens | 16 | 37 | 1128 |
Sonia Panadero | 14 | 41 | 422 |
Ricardo L. Dominguez | 14 | 39 | 1024 |