National Autonomous University of Nicaragua

About: National Autonomous University of Nicaragua is a education organization based out in Managua, Nicaragua. It is known for research contribution in the topics: Population & Public health. The organization has 775 authors who have published 715 publications receiving 9791 citations.

Insecticide residues on hands: assessment and modeling with video observations of determinants of exposure--a study among subsistence farmers in nicaragua.

Abstract: This investigation quantitatively assessed hand residues of chlorpyrifos and methamidophos in a field setting and sought to explain the residues through application volume and determinants of exposure using application data for 28 subsistence farmers in the Pacific Region of Nicaragua. Hand residues were estimated by recovery of the pesticides by standardized wipe sampling for both hands, analyzed with solvent extraction and gas chromatography with electron capture detector. Application volumes were based on data on individual spraying rates and mixing volumes. Eleven determinants of exposure, related to work practices during mixing and spraying of the pesticides, were assessed for each subject from videotapes. Correlation and regression analyses estimated the associations between hand residues, application volume, pesticide type, and determinants of exposure. Correlations between residues for different hand parts were high (r 0.75–0.98). Total hand residue (sum of residues of parts of both hands) correla...

The burden of 14 hr-HPV genotypes in women attending routine cervical cancer screening in 20 states of Mexico: a cross-sectional study.

Abstract: In Mexico, HPV vaccines available immunize against genotypes 16/18 and 16/18/6/11; however, there is limited surveillance about carcinogenic subtypes in different states of the country that allow evaluating the effectiveness of vaccination and cervical cancer screening programs. Here, we report the regional and age-specific prevalence of 14 hr-HPV genotypes as well as their prevalence in abnormal cytology (from ASCUS to cervical cancer) among Mexican women which were undergoing from cervical cancer screening in the Salud Digna clinics in 20 states of the country. This study includes women with social security from the majority of public health institutions (IMSS, ISSSTE, SEMAR, and PEMEX), and women without social security. For cervical cancer screening, we used the SurePath liquid-based cytology and the BD Onclarity HPV Assay. From December 1, 2016, to August 2, 2018, the hr-HPV prevalence among 60,135 women was 24.78%, the most prevalent types were HPV 16 (4.13%), HPV 31 (4.12%) and HPV 51 (3.39%), while HPV 18 (1.70%) was less prevalent among infected women. Interestingly, the genotypes not covered by current vaccines in Mexico were commonly found in precancerous lesions, evidencing their carcinogenic potential, so it is necessary to increase their surveillance and inclusion in cervical cancer screening triage.

Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014).

Abstract: MESTIFAR 2014 28–30 November 2014, Panama City, Panama The CEIBA consortium was created within the Ibero-American network of Pharmacogenetics (RIBEF) to study population pharmacogenetics. The current status of these initiatives and results of the MESTIFAR project were analyzed in Panama, 28–30 November 2014. The MESTIFAR project focused on studying CYPs genetic polymorphisms in populations of different ethnic origin. So far, more than 6000 healthy volunteers have been evaluated, making this one of the largest population pharmacogenomic studies worldwide. Three symposia were organized, ‘Pharmacogenetics of indigenous and mestizos populations and its clinical implications’, ‘Methodological innovation in pharmacogenetics and its application in health’, and ‘General discussion and concluding remarks’, about mechanisms and proposals for training, diffusion of pharmacogenetics for Spanish- and Portuguese-speaking health professionals, and ‘bench to bedside’ pilot projects.

Risk Factors for Norovirus Gastroenteritis among Nicaraguan Children

Abstract: Norovirus is a leading cause of pediatric gastroenteritis. Understanding norovirus epidemiology is essential for reducing disease burden. We conducted a case-control study to describe the distribution, clinical features, and risk factors of norovirus gastroenteritis among children < 5 years of age in Leon, Nicaragua. Cases were children testing positive for norovirus and controls were children living in the cases' communities. Study staff interviewed mothers of enrolled cases and controls to obtain detailed exposure information including food, water, and sanitation sources; recent exposures; household characteristics; and handwashing practices. In addition, study staff requested stool samples to be tested for norovirus from select household members. We used descriptive statistics to understand the epidemiologic and clinical features of gastroenteritis episodes. To analyze potential risk factors, we used Firth's penalized logistic regression to estimate crude and adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs). There were 102 children with gastroenteritis, 18 cases of norovirus and 31 controls. Norovirus cases occurred later in the year, corresponding to a delay in the rainy season. Cases were more likely to have a household member with norovirus in their stool as compared with controls [crude OR: 13.3 (95% CI: 2.5, 136.2) and adjusted OR: 11.5 (95% CI: 1.6, 223.2)]. In addition, alcohol-based hand sanitizer use among household members was reported for 10 (32%) of controls and but never for cases. Further research is needed to understand household transmission of norovirus in low- and middle-income countries and the potential impact of hand sanitizer use.

Elaboración y Caracterización de microcápsulas gastrorresistentes de Diclofenac obtenidas por Gelificación Iónica

Abstract: Se obtuvieron microcapsulas de diclofenac por gelificacion ionica de una solucion de alginato. Se determinaron parametros tales como morfologia, distribucion de tamano de particula, capacidad de encapsulacion y estudios de liberacion in vitro entre otros. La tecnica desarrollada permitio obtener un sistema con caracteristicas micrometricas y una buena eficacia de encapsulacion