Institution
National Chemical Laboratory
Facility•Pune, Maharashtra, India•
About: National Chemical Laboratory is a facility organization based out in Pune, Maharashtra, India. It is known for research contribution in the topics: Catalysis & Nanoparticle. The organization has 8891 authors who have published 14837 publications receiving 387600 citations.
Papers published on a yearly basis
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TL;DR: A detailed time-dependent study of hollow sphere formation reveals that an inside-out Ostwald ripening process is responsible for the hollow sphere formed, and the synthesized covalent organic framework hollow spheres are highly porous and chemically stable, due to the presence of strong intramolecular hydrogen bonding.
Abstract: Hollow, spherical nano/microstructures are potentially useful for energy and drug delivery applications. Here, the authors show that these structures can be fabricated from covalent organic frameworks, and exploit their chemical stability and mesoporous structures for enzyme encapsulation.
420 citations
TL;DR: A facile, salt-mediated synthesis of covalent organic frameworks (COFs) in the presence of p-toluenesulfonic acid resulted in simultaneous chemical delamination and functionalization to targeted CONs, which showed sustained release of the drug to the cancer cells through receptor-mediated endocytosis, which led to cancer cell death via apoptosis.
Abstract: Covalent organic nanosheets (CONs) have emerged as a new class of functional two-dimensional (2D) porous organic polymeric materials with a high accessible surface, diverse functionality, and chemical stability. They could become versatile candidates for targeted drug delivery. Despite their many advantages, there are limitations to their use for target specific drug delivery. We anticipated that these drawbacks could be overturned by judicious postsynthetic modification steps to use CONs for targeted drug delivery. The postsynthetic modification would not only produce the desired functionality, it would also help to exfoliate to CONs as well. In order to meet this requirement, we have developed a facile, salt-mediated synthesis of covalent organic frameworks (COFs) in the presence of p-toluenesulfonic acid (PTSA). The COFs were subjected to sequential postsynthetic modifications to yield functionalized targeted CONs for targeted delivery of 5-fluorouracil to breast cancer cells. This postsynthetic modifi...
419 citations
TL;DR: A solution-based approach to the synthesis of silver (Ag) nanoparticles by chemical reduction of AgNO(3) in a graphene oxide (GrO) suspension is demonstrated and antimicrobial activity of such hybrids materials is investigated against the Gram negative bacteria Escherichia coli and Pseudomonous aeruginosa.
418 citations
TL;DR: The understanding of biochemistry and genetics of chitinolytic enzymes, their phylogenetic relationships and methods of estimation will make them more useful in a variety of processes in near future.
414 citations
TL;DR: This tutorial review organises and presents the advancements in this rapidly growing area of catalysis and in the process updates a previous account published in 2011 in this journal.
Abstract: The use of NHCs for generating homoenolate species has gained widespread popularity in recent years. A number of highly stereoselective processes of NHC-homoenolates have emerged. Homoenolate reactions have also been employed as key steps in the total synthesis of a number of natural products. The use of compatible co-catalysts, improved NHC-catalyst design and the use of novel precursors for homoenolate generation are among the major developments in this area that were disclosed recently. This tutorial review organises and presents the advancements in this rapidly growing area of catalysis and in the process updates a previous account published in 2011 in this journal.
414 citations
Authors
Showing all 8913 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ashok Kumar | 151 | 5654 | 164086 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| Tak W. Mak | 148 | 807 | 94871 |
| John T. O'Brien | 121 | 819 | 63242 |
| Clive Ballard | 117 | 736 | 61663 |
| Yoshinori Tokura | 117 | 858 | 70258 |
| John S. Mattick | 116 | 367 | 64315 |
| Michael Dean | 107 | 419 | 63335 |
| Ian G. McKeith | 107 | 468 | 51954 |
| David J. Burn | 100 | 446 | 39120 |
| Anil Kumar | 99 | 2124 | 64825 |
| Vikas Kumar | 89 | 859 | 39185 |
| Detlef W. Bahnemann | 88 | 517 | 48826 |
| Gautam R. Desiraju | 88 | 458 | 45301 |
| Praveen Kumar | 88 | 1339 | 35718 |