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Showing papers by "National Cheng Kung University published in 2017"


Journal ArticleDOI
31 Mar 2017-Science
TL;DR: The negative effects of climate change cannot be adequately anticipated or prepared for unless species responses are explicitly included in decision-making and global strategic frameworks, and feedbacks on climate itself are documented.
Abstract: Distributions of Earth’s species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of ecological communities, but beyond conservation of natural systems, how and why does this matter? We review evidence that climate-driven species redistribution at regional to global scales affects ecosystem functioning, human well-being, and the dynamics of climate change itself. Production of natural resources required for food security, patterns of disease transmission, and processes of carbon sequestration are all altered by changes in species distribution. Consideration of these effects of biodiversity redistribution is critical yet lacking in most mitigation and adaptation strategies, including the United Nation’s Sustainable Development Goals.

1,917 citations


Journal ArticleDOI
TL;DR: In this phase 3 study, the survival benefits indicate that nivolumab might be a new treatment option for heavily pretreated patients with advanced gastric or gastro-oesophageal junction cancer.

1,512 citations


Journal ArticleDOI
TL;DR: The economic potential assessment of microalgae biorefinery was evaluated and high-value co-products produced through the extraction of a fraction of algae were evaluated to highlight the feasibility of the process.

910 citations


Journal ArticleDOI
TL;DR: This survey introduces the fundamental theories of PHy-security, covering confidentiality and authentication, and provides an overview on the state-of-the-art works on PHY-security technologies that can provide secure communications in wireless systems, along with the discussions on challenges and their proposed solutions.
Abstract: Physical layer security (PHY-security) takes the advantages of channel randomness nature of transmission media to achieve communication confidentiality and authentication. Wiretap coding and signal processing technologies are expected to play vital roles in this new security mechanism. PHY-security has attracted a lot of attention due to its unique features and the fact that our daily life relies heavily on wireless communications for sensitive and private information transmissions. Compared to conventional cryptography that works to ensure all involved entities to load proper and authenticated cryptographic information, PHY-security technologies perform security functions without considering about how those security protocols are executed. In other words, it does not require to implement any extra security schemes or algorithms on other layers above the physical layer. This survey introduces the fundamental theories of PHY-security, covering confidentiality and authentication, and provides an overview on the state-of-the-art works on PHY-security technologies that can provide secure communications in wireless systems, along with the discussions on challenges and their proposed solutions. Furthermore, at the end of this paper, the open issues are identified as our future research directions.

530 citations


Journal ArticleDOI
TL;DR: In this paper, the functional role of a novel circRNA, circCCDC66, in colorectal cancer (CRC) was characterized using RNA-Seq data from matched normal and tumor colon tissue samples.
Abstract: Circular RNA (circRNA) is a class of non-coding RNA whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence is scarce. Here we characterize the functional role of a novel circRNA, circCCDC66, in colorectal cancer (CRC). RNA-Seq data from matched normal and tumor colon tissue samples identified numerous circRNAs specifically elevated in cancer cells, several of which were verified by quantitative RT-PCR. CircCCDC66 expression was elevated in polyps and colon cancer and was associated with poor prognosis. Gain-of-function and loss-of-function studies in CRC cell-lines demonstrated that circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth. In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively. Taken together, these findings highlight a novel oncogenic function of circRNA in cancer progression and metastasis.

509 citations


Journal ArticleDOI
TL;DR: BGJ398 is a first-in-class FGFR kinase inhibitor with manageable toxicities that shows meaningful clinical activity against chemotherapy-refractory cholangiocarcinoma containing FGFR2 fusions.
Abstract: PurposeNo standard treatment exists for patients with cholangiocarcinoma for whom first-line gemcitabine-based therapy fails. Fibroblast growth factor receptor 2 (FGFR2) fusions/translocations are present in 13% to 17% of intrahepatic cholangiocarcinomas. BGJ398, an orally bioavailable, selective pan-FGFR kinase inhibitor, has shown preliminary clinical activity against tumors with FGFR alterations.MethodsA multicenter, open-label, phase II study (ClinicalTrials.gov identifier: NCT02150967) evaluated BGJ398 antitumor activity in patients age ≥ 18 years with advanced or metastatic cholangiocarcinoma containing FGFR2 fusions or other FGFR alterations whose disease had progressed while receiving prior therapy. Patients received BGJ398 125 mg once daily for 21 days, then 7 days off (28-day cycles). The primary end point was investigator-assessed overall response rate.ResultsSixty-one patients (35 women; median age, 57 years) with FGFR2 fusion (n = 48), mutation (n = 8), or amplification (n = 3) participated. ...

473 citations


Journal ArticleDOI
TL;DR: In patients with EGFRm T790M advanced NSCLC who progress after EGFR-TKI treatment, osimertinib provides a high ORR, encouraging PFS, and durable response, and this article reports the results from the phase II extension component.
Abstract: Purpose Osimertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) selective for both EGFR-TKI sensitizing ( EGFRm) and T790M resistance mutations. AURA (NCT01802632) is a phase I/II clinical trial to determine the dose, safety, and efficacy of osimertinib. This article reports the results from the phase II extension component. Patients and Methods Patients with EGFR-TKI-pretreated EGFRm- and T790M-positive advanced non-small-cell lung cancer (NSCLC) received once-daily osimertinib 80 mg. T790M status was confirmed by central testing from a tumor sample taken after the most recent disease progression. Patients with asymptomatic, stable CNS metastases that did not require corticosteroids were allowed to enroll. The primary end point was objective response rate (ORR) by independent radiology assessment. Secondary end points were disease control rate, duration of response, progression-free survival (PFS), and safety. Patient-reported outcomes comprised an exploratory objective. Results In total, 201 patients received treatment, with a median treatment duration of 13.2 months at the time of data cutoff (November 1, 2015). In evaluable patients (n = 198), ORR was 62% (95% CI, 54% to 68%), and the disease control rate was 90% (95% CI, 85 to 94). Median duration of response in 122 responding patients was 15.2 months (95% CI, 11.3 to not calculable). Median PFS was 12.3 months (95% CI, 9.5 to 13.8). The most common possibly causally related adverse events (investigator assessed) were diarrhea (43%; grade ≥ 3, < 1%) and rash (grouped terms; 40%; grade ≥ 3, < 1%). Interstitial lung disease (grouped terms) was reported in eight patients (4%; grade 1, n = 2; grade 3, n = 3; grade 5, n = 3). Conclusion In patients with EGFRm T790M advanced NSCLC who progress after EGFR-TKI treatment, osimertinib provides a high ORR, encouraging PFS, and durable response.

440 citations


Journal ArticleDOI
TL;DR: A detailed investigation on multiple-antenna techniques for guaranteeing secure communications in point-to-point systems, dual-hop relaying systems, multiuser systems, and heterogeneous networks is provided.
Abstract: As a complement to high-layer encryption techniques, physical layer security has been widely recognized as a promising way to enhance wireless security by exploiting the characteristics of wireless channels, including fading, noise, and interference. In order to enhance the received signal power at legitimate receivers and impair the received signal quality at eavesdroppers simultaneously, multiple-antenna techniques have been proposed for physical layer security to improve secrecy performance via exploiting spatial degrees of freedom. This paper provides a comprehensive survey on various multiple-antenna techniques in physical layer security, with an emphasis on transmit beamforming designs for multiple-antenna nodes. Specifically, we provide a detailed investigation on multiple-antenna techniques for guaranteeing secure communications in point-to-point systems, dual-hop relaying systems, multiuser systems, and heterogeneous networks. Finally, future research directions and challenges are identified.

416 citations


Journal ArticleDOI
TL;DR: The review summarizes the current hypotheses for the models of circRNA biosynthesis including the direct interaction between upstream and downstream introns and lariat-driven circularization and the potential roles of circRNAs in neural system, cardiovascular system as well as cancers.
Abstract: A growing body of evidence indicates that circular RNAs are not simply a side product of splicing but a new class of noncoding RNAs in higher eukaryotes. The progression for the studies of circular RNAs is accelerated by combination of several advanced technologies such as next generation sequencing, gene silencing (small interfering RNAs) and editing (CRISPR/Cas9). More and more studies showed that dysregulated expression of circular RNAs plays critical roles during the development of several human diseases. Herein, we review the current advance of circular RNAs for their biosynthesis, molecular functions, and implications in human diseases. Impact statement The accumulating evidence indicate that circular RNA (circRNA) is a novel class of noncoding RNA with diverse molecular functions. Our review summarizes the current hypotheses for the models of circRNA biosynthesis including the direct interaction between upstream and downstream introns and lariat-driven circularization. In addition, molecular functions such as a decoy of microRNA (miRNA) termed miRNA sponge, transcriptional regulator, and protein-like modulator are also discussed. Finally, we reviewed the potential roles of circRNAs in neural system, cardiovascular system as well as cancers. These should provide insightful information for studying the regulation and functions of circRNA in other model of human diseases.

326 citations


Journal ArticleDOI
TL;DR: In this article, the authors empirically examined the dynamic relationships among tourism, economic growth, and CO2 emissions and compared the effects of tourism on economic growth and CO 2 emissions between developed and developing economies.
Abstract: This study empirically examines the dynamic relationships among tourism, economic growth, and CO2 emissions and compares the effects of tourism on economic growth and CO2 emissions between developed and developing economies. By employing robust panel econometric techniques, the results show that tourism has significant positive impacts on economic growth for both developed and developing economies, supporting the prevailing hypothesis of tourism-led economic growth. The results also reveal that the impact of tourism on CO2 emissions is reducing much faster in developed economies than in developing economies, providing evidence of the environmental Kuznets curve (EKC) hypothesis on the link between tourism growth and CO2 emissions. Our findings demonstrate the importance of the classification of countries by economic development level to obtain a deeper understanding of relationships among tourism, economic growth, and CO2 emissions. Policy implications are provided and discussed.

324 citations


Journal ArticleDOI
TL;DR: In particular, the Fermi surfaces of chiral semimetals carry quantized Chern numbers, making them an attractive platform for the observation of exotic transport and optical phenomena as discussed by the authors.
Abstract: The theoretical proposal of chiral fermions in topological semimetals has led to a significant effort towards their experimental realization. In particular, the Fermi surfaces of chiral semimetals carry quantized Chern numbers, making them an attractive platform for the observation of exotic transport and optical phenomena. While the simplest example of a chiral fermion in condensed matter is a conventional $|C|=1$ Weyl fermion, recent theoretical works have proposed a number of unconventional chiral fermions beyond the standard model which are protected by unique combinations of topology and crystalline symmetries. However, materials candidates for experimentally probing the transport and response signatures of these unconventional fermions have thus far remained elusive. In this Letter, we propose the RhSi family in space group No. 198 as the ideal platform for the experimental examination of unconventional chiral fermions. We find that RhSi is a filling-enforced semimetal that features near its Fermi surface a chiral double sixfold-degenerate spin-1 Weyl node at $R$ and a previously uncharacterized fourfold-degenerate chiral fermion at $\mathrm{\ensuremath{\Gamma}}$. Each unconventional fermion displays Chern number $\ifmmode\pm\else\textpm\fi{}4$ at the Fermi level. We also show that RhSi displays the largest possible momentum separation of compensative chiral fermions, the largest proposed topologically nontrivial energy window, and the longest possible Fermi arcs on its surface. We conclude by proposing signatures of an exotic bulk photogalvanic response in RhSi.

Journal ArticleDOI
TL;DR: The approach with low-cost, semiconductor fabrication compatibility and high working efficiency characteristics offers a way for establishing a complete set of flat optical components for a wide range of applications such as compact imaging sensors, optical spectroscopy, and high-resolution lithography, just named a few.
Abstract: Metasurface-based components are known to be one of the promising candidates for developing flat optical systems. However, their low working efficiency highly limits the use of such flat components for feasible applications. Although the introduction of the metallic mirror has been demonstrated to successfully enhance the efficiency, it is still somehow limited for imaging and sensing applications because they are only available for devices operating in a reflection fashion. Here, we demonstrate three individual GaN-based metalenses working in a transmission window with extremely high operation efficiency at visible light (87%, 91.6%, and 50.6% for blue, green, and red light, respectively). For the proof of concept, a multiplex color router with dielectric metalens, which is capable of guiding individual primary colors into different spatial positions, is experimentally verified based on the design of out-of-plane focusing metalens. Our approach with low-cost, semiconductor fabrication compatibility and h...

Journal ArticleDOI
TL;DR: This review aims to provide updated information on the development of algal biochar in terms of the production methods and the characterization of its physical and chemical properties to justify and to expand their potential applications.

Journal ArticleDOI
TL;DR: The heterotrophic metabolic potential of microalgae and their uses in pigment production are comprehensively described and strategies to enhance pigment production underheterotrophic conditions are critically discussed and the challenges faced in heterotrophe pigment production with possible alternative solutions are presented.

Journal ArticleDOI
TL;DR: In this paper, 2D titanium carbide, Ti3C2Tx, enhances Raman signal from organic dyes on a substrate and in solution, with calculated enhancement factors reaching ∼106.
Abstract: Noble metal (gold or silver) nanoparticles or patterned films are typically used as substrates for surface-enhanced Raman spectroscopy (SERS). Two-dimensional (2D) carbides and nitrides (MXenes) exhibit unique electronic and optical properties, including metallic conductivity and plasmon resonance in the visible or near-infrared range, making them promising candidates for a wide variety of applications. Herein, we show that 2D titanium carbide, Ti3C2Tx, enhances Raman signal from organic dyes on a substrate and in solution. As a proof of concept, MXene SERS substrates were manufactured by spray-coating and used to detect several common dyes, with calculated enhancement factors reaching ∼106. Titanium carbide MXene demonstrates SERS effect in aqueous colloidal solutions, suggesting the potential for biomedical or environmental applications, where MXene can selectively enhance positively charged molecules.

Journal ArticleDOI
13 Sep 2017-Nature
TL;DR: New light is shed on the genetic mechanisms underpinning key orchid innovations, including the development of the labellum and gynostemium, pollinia, and seeds without endosperm, as well as the evolution of epiphytism; reveals relationships between the Orchidaceae subfamilies; and helps clarify the evolutionary history of orchids within the angiosperms.
Abstract: Constituting approximately 10% of flowering plant species, orchids (Orchidaceae) display unique flower morphologies, possess an extraordinary diversity in lifestyle, and have successfully colonized almost every habitat on Earth. Here we report the draft genome sequence of Apostasia shenzhenica, a representative of one of two genera that form a sister lineage to the rest of the Orchidaceae, providing a reference for inferring the genome content and structure of the most recent common ancestor of all extant orchids and improving our understanding of their origins and evolution. In addition, we present transcriptome data for representatives of Vanilloideae, Cypripedioideae and Orchidoideae, and novel third-generation genome data for two species of Epidendroideae, covering all five orchid subfamilies. A. shenzhenica shows clear evidence of a whole-genome duplication, which is shared by all orchids and occurred shortly before their divergence. Comparisons between A. shenzhenica and other orchids and angiosperms also permitted the reconstruction of an ancestral orchid gene toolkit. We identify new gene families, gene family expansions and contractions, and changes within MADS-box gene classes, which control a diverse suite of developmental processes, during orchid evolution. This study sheds new light on the genetic mechanisms underpinning key orchid innovations, including the development of the labellum and gynostemium, pollinia, and seeds without endosperm, as well as the evolution of epiphytism; reveals relationships between the Orchidaceae subfamilies; and helps clarify the evolutionary history of orchids within the angiosperms.

Journal ArticleDOI
TL;DR: The potential types of algae in contributing carbohydrate and lipids to produce biofuel such as biodiesel, bioethanol and bio-gas are reviewed and economic feasibilities of algae based fuel production are discussed based on Life Cycle Analysis.

Journal ArticleDOI
M. Aguilar, O. Demakov1, Ying Lu2, U. Becker1  +253 moreInstitutions (27)
TL;DR: The observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10−6 helium, 8.4×10^{6} carbon, and 7.0×10 6} oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation are reported.
Abstract: We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×106 helium, 8.4×106 carbon, and 7.0×106 oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.

Journal ArticleDOI
TL;DR: The present work reviews the current biodiesel feedstock, catalysis, general and novel immobilizing materials, bioreactors, potential lipase resources, intensification technics, and process modelling for enzymatic transesterification.

Journal ArticleDOI
TL;DR: A state-of-the art review on recent research activities in pyrolysis characteristics and kinetics of various microalgae, includingThermogravimetric analysis, and common kinetic models predicting the thermal degradation ofmicroalgae are examined.

Journal ArticleDOI
TL;DR: This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.

Journal ArticleDOI
TL;DR: Blue-emission (≈470 nm) Cs-based perovskite NCs are derived by directly mixing synthesized bromide and chloride nanocrystals with a weight ratio of 2:1.
Abstract: Inorganic metal halide perovskite nanocrystals (NCs) have been employed universally in light-emitting applications during the past two years. Here, blue-emission (≈470 nm) Cs-based perovskite NCs are derived by directly mixing synthesized bromide and chloride nanocrystals with a weight ratio of 2:1. High-brightness blue perovskite light-emitting diodes (PeLEDs) are obtained by controlling the grain size of the perovskite films. Moreover, a white PeLED is demonstrated for the first time by blending orange polymer materials with the blue perovskite nanocrystals as the active layer. Exciton transfer from the blue nanocrystals to the orange polymers via Forster or Dexter energy transfer is analyzed through time resolved photoluminescence. By tuning the ratio between the perovskite nanocrystals and polymers, pure white light is achieved with the a CIE coordinate at (0.33,0.34).

Journal ArticleDOI
TL;DR: The bottlenecks in microalgae-based biohydrogen production are critically reviewed, the enzymes involved and the factors affecting the bioHydrogen production process are discussed, and future research areas in hydrogen production are presented.

Journal ArticleDOI
TL;DR: The direct observation of the type II Weyl fermions in crystalline solid lanthanum aluminum germanide (LaAlGe) is presented based on photoemission data alone, without reliance on band structure calculations, and systematic data agree with the theoretical calculations, providing further support on the experimental results.
Abstract: In quantum field theory, Weyl fermions are relativistic particles that travel at the speed of light and strictly obey the celebrated Lorentz symmetry. Their low-energy condensed matter analogs are Weyl semimetals, which are conductors whose electronic excitations mimic the Weyl fermion equation of motion. Although the traditional (type I) emergent Weyl fermions observed in TaAs still approximately respect Lorentz symmetry, recently, the so-called type II Weyl semimetal has been proposed, where the emergent Weyl quasiparticles break the Lorentz symmetry so strongly that they cannot be smoothly connected to Lorentz symmetric Weyl particles. Despite some evidence of nontrivial surface states, the direct observation of the type II bulk Weyl fermions remains elusive. We present the direct observation of the type II Weyl fermions in crystalline solid lanthanum aluminum germanide (LaAlGe) based on our photoemission data alone, without reliance on band structure calculations. Moreover, our systematic data agree with the theoretical calculations, providing further support on our experimental results.

Journal ArticleDOI
TL;DR: In this article, a review of thermochemical conversion technologies involving microalgal biomass is presented, with emphasis on the background chemistry and chemical processes, and the pros and cons of direct combustion are also spotlighted.

Journal ArticleDOI
TL;DR: A solution-processed carbon quantum dots (CQDs)/TiO2 composite that has negligible absorption in the visible spectral range, a very attractive feature for perovskite solar cells is reported.
Abstract: In planar n-i-p heterojunction perovskite solar cells, the electron transport layer (ETL) plays important roles in charge extraction and determine the morphology of the perovskite film. Here, we report a solution-processed carbon quantum dots (CQDs)/TiO2 composite that has negligible absorption in the visible spectral range, a very attractive feature for perovskite solar cells. Using this novel CQDs/TiO2 ETL in conjunction with a planar n-i-p heterojunction, we achieved an unprecedented efficiency of ∼19% under standard illumination test conditions. It was found that a CQDs/TiO2 combination increases both the open circuit voltage and short-circuits current density as compared to using TiO2 alone. Various advanced spectroscopic characterizations including ultrafast spectroscopy, ultraviolet photoelectron spectroscopy, and electronic impedance spectroscopy elucidate that the CQDs increases the electronic coupling between the CH3NH3PbI3–xClx and TiO2 ETL interface as well as energy levers that contribute to ...

Journal ArticleDOI
TL;DR: This study demonstrates a successful example of waste refinery by converting anaerobic digestion sludge to feasible heavy metal adsorbents to implement the concept of circular economy.

Journal ArticleDOI
TL;DR: A novel fabrication method for producing a dual-modality biosensor that can simultaneously detect vascular endothelial growth factor (VEGF) and prostate-specific antigen (PSA) in human serum for early diagnosis of PCa is reported.

Journal ArticleDOI
TL;DR: A formamidinium(FA)-based perovskite showns superior optoelectronic properties including better stability than methylammonium-based counterparts, and Interestingly, the LED clearly shows a sub-bandgap emission at 1.7 V (bandgap 2.3 eV).
Abstract: A formamidinium(FA)-based perovskite showns superior optoelectronic properties including better stability than methylammonium-based counterparts. Pure FA-perovskite-based light-emitting diodes (LEDs) with high efficiency are reported. Interestingly, the LED clearly shows a sub-bandgap emission at 1.7 V (bandgap 2.3 eV). This important discovery provides further insights of the charge transport mechanism in perovskite-based optoelectronic devices.

Journal ArticleDOI
TL;DR: In this paper, a facile and green preparation of cuprous oxide-reduced graphene oxide (Cu2O-rGO) nanoheterostructures through a photochemical reaction was demonstrated.
Abstract: We demonstrated a facile and green preparation of cuprous oxide-reduced graphene oxide (Cu2O-rGO) nanoheterostructures through a photochemical reaction. The density of Cu2O nanocubes (NCs) grown on the rGO surface can be well controlled by modulating the concentration of GO employed in the reaction. Because of the relatively low potential of Fermi level of rGO, the photoexcited electrons on the conduction band (CB) of Cu2O NCs preferentially transfer to rGO, simultaneously leaving photogenerated holes on the valence band (VB) of Cu2O, resulting in the notable charge carrier separation properties. Time-resolved photoluminescence (TRPL) spectra were collected to quantitatively analyze the electron transfer rate constant ( k et ) between Cu2O NCs and rGO, and the dependence of the ket on the rGO constituent in Cu2O-rGO nanoheterostructures. Among all the samples tested, the Cu2O-rGO nanoheterostructure with the rGO constituent of 2 wt.% (denoted as Cu2O-rGO-2) displayed the largest ket as well as the most pronounced charge separation property. The optimized Cu2O-rGO-2 showed the best methyl orange (MO) photocatalytic degradation performance, which was highly consistent with the trend of the obtained k et results. As compared with relevant commercial products, such as N-doped P-25 TiO2 and commercial Cu2O powders, the Cu2O-rGO-2 exhibited superior efficiency toward MO degradation under visible light illumination, illustrating its potential for applications in relevant photoelectric conversion processes. The recycling trial showed that the Cu2O-rGO-2 has promising potential for use in the long-term course of photocatalysis to degrade organic pollutants. Furthermore, the photocatalytic efficiency evaluated under natural sunlight demonstrated that the present Cu2O-rGO nanoheterostructure could effectively harvest the energy of solar spectrum and converted it into the chemical energy for organic pollutants degradation. The current study could provide great insights into the design of semiconductor/graphene composites which exhibit remarkable charge separation properties for practical applications in the organic pollutants photodegradation, solar fuel generation as well as photovoltaic devices.