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Institution

National Cheng Kung University

EducationTainan City, Taiwan
About: National Cheng Kung University is a education organization based out in Tainan City, Taiwan. It is known for research contribution in the topics: Population & Thin film. The organization has 49723 authors who have published 69799 publications receiving 1437420 citations. The organization is also known as: NCKU.


Papers
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Journal ArticleDOI
TL;DR: The novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression is discussed, which enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis.
Abstract: Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.

222 citations

Journal ArticleDOI
TL;DR: These results confirm that the proposed starch/gelatin microneedles enable stable encapsulation of bioactive molecules and have great potential for transdermal delivery of protein drugs in a relatively painless, rapid, and convenient manner.

222 citations

Journal ArticleDOI
TL;DR: In this paper, the authors report the global transient luminous event (TLE) distributions and rates based on the Imager of Sprites and Upper Atmospheric Lightning (ISUAL) experiment onboard the FORMOSAT-2 satellite.
Abstract: [1] We report the global transient luminous event (TLE) distributions and rates based on the Imager of Sprites and Upper Atmospheric Lightning (ISUAL) experiment onboard the FORMOSAT-2 satellite. ISUAL observations cover 45°S to 25°N latitude during the northern summer and 25°S to 45°N latitude during the northern winter. From July 2004 to June 2007, ISUAL recorded 5,434 elves, 633 sprites, 657 halos, and 13 gigantic jets. Surprisingly, elve is the dominant type of TLEs, while sprites/halos are a distant second. Elve occurrence rate jumps as the sea surface temperature exceeds 26 degrees Celsius, manifesting an ocean-atmosphere-ionosphere coupling. In the ISUAL survey, elves concentrate over the Caribbean Sea, South China Sea, east Indian Ocean, central Pacific Ocean, west Atlantic Ocean, and southwest Pacific Ocean; while sprites congregate over central Africa, Japan Sea, and west Atlantic Ocean. The ISUAL experiment observed global rates of 3.23, 0.50, 0.39, and 0.01 events per minute for elves, sprites, halos, and gigantic jets, respectively. Taking the instrumental detection sensitivity and the restricted survey area into account, the corrected global occurrence rates for sprites and elves likely are a factor of two and an order of magnitude higher, respectively. ISUAL observations also indicate that the relative frequency of high peak current lightning (>80 kA) is 10 times higher over the oceans than over the land. On the basis of the corrected ISUAL elve global occurrence rate, the total electron content at the lower ionosphere above elve hot zones was computed to be elevated by more than 5%.

222 citations

Journal ArticleDOI
TL;DR: If the mean BI change score within a stroke group has reached 1.85 points in a study, the change score on the BI can be perceived by patients as important and beyond measurement error (ie, such a change score is clinically important).
Abstract: Background. The interpretation of the change scores of the Barthel Index (BI) in follow-up or outcome studies has been hampered by the fact that its minimal clinically important difference (MCID) has not been determined. Objective. This article was written to establish the MCID of the BI in stroke patients. Methods. Both anchor-based and distribution-based methods were used to establish the MCID. In the anchor-based method, 43 stroke inpatients participated in a follow-up study designed to determine the MCID of the BI using patients' global ratings of the activities of daily living function on a 15-point Likert-type scale. The mean change scores on the 20-point scale of the BI of the MCID group, based on the patients' ratings on the Likert-type scale, served as the first estimate of the MCID. In the distribution-based method, 56 chronic stroke patients participated in the test-retest reliability study to determine the MCID of the BI. One standard error of measurement (SEM) served as the second estimate fo...

222 citations

Journal ArticleDOI
TL;DR: Li contents and isotopic compositions were determined for a suite of well-characterized basaltic lavas from the Central American Volcanic Arc (CAVA) as discussed by the authors, and these correlations are particularly strong for Nicaragua samples.

221 citations


Authors

Showing all 49872 results

NameH-indexPapersCitations
Yi Chen2174342293080
Yang Yang1642704144071
R. E. Hughes1541312110970
Mercouri G. Kanatzidis1521854113022
Thomas J. Smith1401775113919
Hui Li1352982105903
Gerald M. Reaven13379980351
Chi-Huey Wong129122066349
Joseph P. Vacanti11944150739
Kai Nan An10995351638
Ding-Shinn Chen10477446068
James D. Neaton10133164719
David C. Christiani100105255399
Jo Shu Chang9963937487
Yu Shyr9854239527
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202373
2022315
20213,425
20203,154
20192,895
20182,764