National Cheng Kung University

About: National Cheng Kung University is a education organization based out in Tainan City, Taiwan. It is known for research contribution in the topics: Population & Thin film. The organization has 49723 authors who have published 69799 publications receiving 1437420 citations. The organization is also known as: NCKU.

Surface Curvature Effect on Slot-Air-Jet Impingement Cooling Flow and Heat Transfer Process

Abstract: Experiments are performed to study 'surface curvature effects on the impingement cooling flow and the heat transfer processes over a concave and a convex surface. A single air jet issuing from different size slots continuously impinges normally on the concave side or the convexside of a heated semicylindrical surface. An electrical resistance wire is used to generate smoke, which allows us to visualize the impinging flow structure. The local heat transfer Nusselt number along the surfaces is measured. For impingement on a convex surface, three-dimensional counterrotating vortices on the stagnation point are initiated, which result in the enhancement of the heat transfer process. For impingement on a concave surface, the heat transfer Nusselt number increases with increasing surface curvature, which suggests the initiation of Taylor-Gortler vortices along the surface. In the experiment, the Reynolds number ranges from 6000 to 350,000, the slot-to-plate spacing from 2 to 16, and the diameter-to-slot-width ratio D/b from 8 to 45.7. Correlations of both the stagnation point and the average Nusselt number over the curved surface, which account for the surface curvature effect, are presented. 1 Introduction Impingement cooling has been widely used to cool a heat transfer component exposed to a high temperature or a high heat flux environment. The impingement cooling jet has the advantage that it is readily moved to the location of interest and removes a large amount of heat. It has been widely used in such industrial systems as high-temperature gas turbines, paper drying, glass manufacturing, and high-density electronic equipment. The impinging jet used in these systems is air. Over the past 30 years, impingement cooling heat transfer has been extensively studied. Good review articles are available (Martin, 1977; Becko, 1976). The impinging flow structure (Donaldson and Snedeker, 1971a, 1971b), the local heat transfer, and the correlations of average Nusselt number in terms of relevant parameters have been well studied (Gardon and Cobonpue, 1963; Gardon and Akfirat, 1966; Korger and Krizek, 1965; Zumbrunnen et al., 1989). However, the impingement cooling studied in the past was on a flat plate. The situation of impingement cooling over a curved surface may frequently be encountered. However, the studies of impingement cooling on a curved surface are rela­tively few. Chupp et al. (1969) studied the impingement cooling heat transfer for an array of round jets impinging on a concave surface. The geometric configuration studied is very similar to the case for cooling of the leading edge of a gas turbine airfoil. They measure the local Nusselt number and correlate the av­erage Nusselt number in terms of the Reynolds number, the nozzle-to-plate spacing, and some nondimensional parameters of geometry. However, the local heat transfer obtained is ac­tually an average over a relatively large space. A similar ge­ometry is also studied by Metzger et al. (1969,1972) and Hrycak (1978, 1981). Tabakoff and Clevenger (1972) study three dif­ferent configurations of impinging jets on a concave surface: the single slot jet, the one-dimensional row of round jets, and the two-dimensional array of jets. Both the local and the av­erage Nusselt number are determined. However, the local heat transfer Nusselt number obtained is again an average over a relatively large space. A few correlations of average Nusselt numbers for slot jet impingement cooling over a concave or a

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

Abstract: Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10 27 or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p=1.30610 211 ). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p=5.38610 211 ). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the CLPTM1L-TERT locus on chromosome 5p15.33 (p=2.60610 220 , allelic risk=1.54, 95% Confidence Interval (CI) 1.41–1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40–1.87), and 2.35 (95% CI: 1.95–2.83), respectively. In summary, our results show that genetic variation in the CLPTM1LTERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.