Institution
National Cheng Kung University
Education•Tainan City, Taiwan•
About: National Cheng Kung University is a education organization based out in Tainan City, Taiwan. It is known for research contribution in the topics: Population & Thin film. The organization has 49723 authors who have published 69799 publications receiving 1437420 citations. The organization is also known as: NCKU.
Topics: Population, Thin film, Dielectric, Heat transfer, Microstructure
Papers published on a yearly basis
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TL;DR: A developed consortium-GR completely decolorized an azo dye Scarlet R under static anoxic condition with an average decolorization rate of 16,666 microg h(-1); which is much faster than that of the pure cultures.
354 citations
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Stanford University1, University of Colorado Denver2, University of Edinburgh3, Oregon Health & Science University4, Fraunhofer Society5, University of California, Berkeley6, Ludwig Maximilian University of Munich7, Arizona State University8, Dresden University of Technology9, Harbin Institute of Technology10, National Cheng Kung University11, Yale University12, National Institutes of Health13, Georgetown University Medical Center14, Academia Sinica15, Erasmus University Rotterdam16, Mitre Corporation17
TL;DR: Major advances for the BioCreative II gene normalization task include broader participation (20 versus 8 teams) and a pooled system performance comparable to human experts, at over 90% agreement, which show promise as tools to link the literature with biological databases.
Abstract: Background: The goal of the gene normalization task is to link genes or gene products mentioned in the literature to biological databases. This is a key step in an accurate search of the biological literature. It is a challenging task, even for the human expert; genes are often described rather than referred to by gene symbol and, confusingly, one gene name may refer to different genes (often from different organisms). For BioCreative II, the task was to list the Entrez Gene identifiers for human genes or gene products mentioned in PubMed/MEDLINE abstracts. We selected abstracts associated with articles previously curated for human genes. We provided 281 expert-annotated
354 citations
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TL;DR: Using logistic regression analyses, positive relationships between Internet addiction and male gender, neuroticism scores and the CHQ score are found and the freshmen who skipped breakfast and those who had poorer social support also had a higher probability of Internet addiction.
Abstract: This study was designed to explore the risk factors of Internet addiction in 1360 freshmen of the National Cheng Kung University in Taiwan in 2003. The test battery included a self-administrated structured questionnaire, the Chinese Internet Addiction Scale-Revision (CIAS-R), the 12-item Chinese Health Questionnaire (CHQ-12), the Measurement of Support Functions (MSF), and the neuroticism subscale of the Maudsley Personality Inventory (MPI). Of the total study population, there were 680 college freshmen (17.9%) in the Internet addiction group, as defined by high CIAS-R scores. Using logistic regression analyses, we found positive relationships between Internet addiction and male gender, neuroticism scores and the CHQ score. In addition, the freshmen who skipped breakfast and those who had poorer social support also had a higher probability of Internet addiction. Internet addiction is prevalent among university freshmen in Taiwan. Risk factors included male gender, habit of skipping breakfast, mental health morbidity, deficient social support; and neurotic personality characteristics.
353 citations
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TL;DR: The results show that biosurfactants exhibited much higher TPH removal efficiency than the synthetic ones examined, and increased with an increase in biosurFactant concentration.
352 citations
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TL;DR: If the hypothesis being tested in the EPHESUS trial proves correct, eplerenone has the potential to be used in a broad population to prevent progressive left ventricular remodeling, ventricular fibrosis, malignant arrhythmias, non-fatal AMI, and sudden cardiac death.
Abstract: The importance of aldosterone in the pathophysiology of chronic heart failure (HF) has been established in previous studies [1–4] and is emphasized by the findings of the RALES trial [5]. In this study, aldosterone blockade with spironolactone resulted in a 30% reduction in total mortality and a 35% reduction in hospitalizations for HF in patients with pre-existing chronic severe HF. Patients in the RALES trial also received standard therapy including an ACE inhibitor (if tolerated), a loop diuretic, and digoxin. While aldosterone receptor blockade has been proven beneficial in severe chronic HF due to systolic left ventricular (LV) dysfunction, its effects in patients with acute myocardial infarction (AMI) complicated by HF due to systolic left ventricular dysfunction are unknown. The pathophysiology of HF complicating AMI is complex. Factors such as the acute release of catecholamines, activation of the renin angiotensin aldosterone system, degree of ventricular remodeling, myocardial scar formation, extent of coronary artery disease, and residual ischemia may differ both quantitatively and qualitatively in patients with acute infarction compared to patients with chronic HF. Additionally, the extent of activation of cytokines, fibrinolytic balance, and activity of clotting factors may differ. Eplerenone was chosen for this study because of its demonstrated efficacy in an experimental model of AMI [6]. In clinical trials, eplerenone demonstrated efficacy similar to spironolactone in blocking aldosterone receptors, lowering blood pressure, and moderating hormonal and neurohormonal markers of HF [7,8]. However, eplerenone has significantly less affinity for androgen and progesterone receptors and should therefore be associated with a lower incidence of gynecomastia, breast pain and impotency in males, and diminished libido and menstrual irregularities in females [9–11]. While older patients suffering from refractory HF may tolerate these androgenic and progestational side effects, they may preclude widespread use of a nonspecific aldosterone antagonist in younger patients or in patients with less severe cardiac compromise. Since eplerenone is at least 100 times more specific in its affinity for aldosterone receptors than is spironolactone, if the hypothesis being tested in the EPHESUS trial proves correct, eplerenone has the potential to be used in a broad population to prevent progressive left ventricular remodeling, ventricular fibrosis, malignant arrhythmias, non-fatal AMI, and sudden cardiac death. We hypothesize that selective aldosterone receptor blockade with eplerenone will have a beneficial effect on survival and morbidity in patients with AMI complicated by HF due to systolic left ventricular dysfunction. This paper describes the background, design, and organization of a trial to test this hypothesis—the EPHESUS trial (Eplerenone Post-AMI Heart Failure Efficacy and Survival Study).
349 citations
Authors
Showing all 49872 results
Name | H-index | Papers | Citations |
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Yi Chen | 217 | 4342 | 293080 |
Yang Yang | 164 | 2704 | 144071 |
R. E. Hughes | 154 | 1312 | 110970 |
Mercouri G. Kanatzidis | 152 | 1854 | 113022 |
Thomas J. Smith | 140 | 1775 | 113919 |
Hui Li | 135 | 2982 | 105903 |
Gerald M. Reaven | 133 | 799 | 80351 |
Chi-Huey Wong | 129 | 1220 | 66349 |
Joseph P. Vacanti | 119 | 441 | 50739 |
Kai Nan An | 109 | 953 | 51638 |
Ding-Shinn Chen | 104 | 774 | 46068 |
James D. Neaton | 101 | 331 | 64719 |
David C. Christiani | 100 | 1052 | 55399 |
Jo Shu Chang | 99 | 639 | 37487 |
Yu Shyr | 98 | 542 | 39527 |