Institution
National Foundation for Cancer Research
Nonprofit•Bethesda, Maryland, United States•
About: National Foundation for Cancer Research is a nonprofit organization based out in Bethesda, Maryland, United States. It is known for research contribution in the topics: Peptide sequence & Gene. The organization has 1639 authors who have published 1673 publications receiving 147520 citations.
Topics: Peptide sequence, Gene, Receptor, Fibronectin, Cell culture
Papers published on a yearly basis
Papers
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TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
Abstract: Rapid progress has been made in the understanding of the molecular interactions that result in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood contain the tripeptide arginine-glycine-aspartic acid (RGD) as their cell recognition site. These proteins include fibronectin, vitronectin, osteopontin, collagens, thrombospondin, fibrinogen, and von Willebrand factor. The RGD sequences of each of the adhesive proteins are recognized by at least one member of a family of structurally related receptors, integrins, which are heterodimeric proteins with two membrane-spanning subunits. Some of these receptors bind to the RGD sequence of a single adhesion protein only, whereas others recognize groups of them. The conformation of the RGD sequence in the individual proteins may be critical to this recognition specificity. On the cytoplasmic side of the plasma membrane, the receptors connect the extracellular matrix to the cytoskeleton. More than ten proved or suspected RGD-containing adhesion-promoting proteins have already been identified, and the integrin family includes at least as many receptors recognizing these proteins. Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
4,821 citations
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TL;DR: The bax gene promoter region contains four motifs with homology to consensus p53-binding sites and wild-type but not mutant p53 protein bound to oligonucleotides corresponding to this region of the bax promoter, suggesting that bax is a p53 primary-response gene, presumably involved in a p 53-regulated pathway for induction of apoptosis.
4,150 citations
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TL;DR: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl- L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronsectin and present in at least five other proteins.
Abstract: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl-L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronectin and present in at least five other proteins. This tetrapeptide may constitute a cellular recognition determinant common to several proteins.
3,574 citations
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TL;DR: It is demonstrated that apoptosis was induced by disruption of the interactions between normal epithelial cells and extracellular matrix, and the circumvention of anoikis accompanies the acquisition of anchorage independence or cell motility.
Abstract: Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure, differentiation, and aspects of cell growth control. Programmed cell death (apoptosis) is crucial for maintaining appropriate cell number and tissue organization. It was therefore of interest to determine whether cell-matrix interactions affect apoptosis. The present report demonstrates that apoptosis was induced by disruption of the interactions between normal epithelial cells and extracellular matrix. We have termed this phenomenon "anoikis." Overexpression of bcl-2 protected cells against anoikis. Cellular sensitivity to anoikis was apparently regulated: (a) anoikis did not occur in normal fibroblasts; (b) it was abrogated in epithelial cells by transformation with v-Ha-ras, v-src, or treatment with phorbol ester; (c) sensitivity to anoikis was conferred upon HT1080 cells or v-Ha-ras-transformed MDCK cells by reverse-transformation with adenovirus E1a; (d) anoikis in MDCK cells was alleviated by the motility factor, scatter factor. The results suggest that the circumvention of anoikis accompanies the acquisition of anchorage independence or cell motility.
3,134 citations
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TL;DR: A committee of several scientists who have been involved in the identification and characterization of these enzymes have formed a committee, with the objective of proposing a nomenclature for the human members of this protease family that is sensible and easy to use.
2,451 citations
Authors
Showing all 1640 results
Name | H-index | Papers | Citations |
---|---|---|---|
John C. Reed | 190 | 891 | 164382 |
Zena Werb | 168 | 473 | 122629 |
Erkki Ruoslahti | 159 | 600 | 101072 |
Stuart F. Schlossman | 132 | 587 | 61845 |
Ajit Varki | 124 | 542 | 58772 |
Stephen C. Harrison | 123 | 420 | 59495 |
Channing J. Der | 122 | 425 | 59736 |
Sai-Juan Chen | 121 | 1211 | 73991 |
David M. Livingston | 118 | 312 | 58142 |
Mark H. Ellisman | 117 | 637 | 55289 |
Guy S. Salvesen | 116 | 337 | 75598 |
Francesco Blasi | 108 | 918 | 43534 |
Gary Cutter | 103 | 737 | 40507 |
Hiroshi Maeda | 103 | 893 | 63370 |
Robert G. Maki | 100 | 416 | 39234 |