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Institution

National Health and Family Planning Commission

GovernmentBeijing, China
About: National Health and Family Planning Commission is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Kashin–Beck disease. The organization has 2379 authors who have published 1440 publications receiving 20078 citations. The organization is also known as: Ministry of Health of the People's Republic of China.

Papers published on a yearly basis

Papers
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Journal ArticleDOI
TL;DR: An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-n coV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.

1,864 citations

Journal ArticleDOI
01 Dec 2016-Cell
TL;DR: It is demonstrated that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice, and suggests that ZikV infection, under certain circumstances, can eventually lead to male infertility.

414 citations

Journal ArticleDOI
TL;DR: It is shown that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II, which appears to be linked to the severity and lethality of infection, at least in some patients.
Abstract: The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection, at least in some patients. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. Genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice, confirming a role of ACE2 in H5N1-induced lung pathologies. Administration of recombinant human ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice. Our data link H5N1 virus-induced acute lung failure to ACE2 and provide a potential treatment strategy to address future flu pandemics.

358 citations

Journal ArticleDOI
25 Jul 2013-Nature
TL;DR: It is shown that the emerging H7N9 avian influenza virus poses a potentially high risk to humans, and current seasonal vaccination could not provide protection.
Abstract: Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China. A total of 132 confirmed cases and 39 deaths have been reported. Most patients presented with severe pneumonia and acute respiratory distress syndrome. Although the first epidemic has subsided, the presence of a natural reservoir and the disease severity highlight the need to evaluate its risk on human public health and to understand the possible pathogenesis mechanism. Here we show that the emerging H7N9 avian influenza virus poses a potentially high risk to humans. We discover that the H7N9 virus can bind to both avian-type (α2,3-linked sialic acid) and human-type (α2,6-linked sialic acid) receptors. It can invade epithelial cells in the human lower respiratory tract and type II pneumonocytes in alveoli, and replicated efficiently in ex vivo lung and trachea explant culture and several mammalian cell lines. In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected. We note that the human population is naive to the H7N9 virus, and current seasonal vaccination could not provide protection.

339 citations

Journal ArticleDOI
TL;DR: The sex ratios in urban compared with rural cases are consistent with exposure to poultry driving the risk of infection--a higher risk in men was only recorded in urban areas but not in rural areas, and the increased risk for men was of a similar magnitude for H7N9 and H5N1.

281 citations


Authors

Showing all 2403 results

NameH-indexPapersCitations
Feng Zhang1721278181865
Yang Yang1712644153049
Lei Zhang135224099365
Jian Zhang107306469715
Wei Wang95354459660
Jie Li7684332221
Jing Liu73135127169
Haidong Kan7140544210
Wei Wang6667320023
Jin-Tai Yu6643920020
Qi Jin6433545892
Chuan Qin6032621708
Ji-Sheng Han6033913660
Ying Zhou6066314349
Jun Huang5744512176
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202314
202220
2021131
2020166
2019188
2018262