Institution
National Health and Family Planning Commission
Government•Beijing, China•
About: National Health and Family Planning Commission is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Kashin–Beck disease. The organization has 2379 authors who have published 1440 publications receiving 20078 citations. The organization is also known as: Ministry of Health of the People's Republic of China.
Papers
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TL;DR: An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-n coV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
1,864 citations
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TL;DR: It is demonstrated that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice, and suggests that ZikV infection, under certain circumstances, can eventually lead to male infertility.
414 citations
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TL;DR: It is shown that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II, which appears to be linked to the severity and lethality of infection, at least in some patients.
Abstract: The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection, at least in some patients. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. Genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice, confirming a role of ACE2 in H5N1-induced lung pathologies. Administration of recombinant human ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice. Our data link H5N1 virus-induced acute lung failure to ACE2 and provide a potential treatment strategy to address future flu pandemics.
358 citations
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TL;DR: It is shown that the emerging H7N9 avian influenza virus poses a potentially high risk to humans, and current seasonal vaccination could not provide protection.
Abstract: Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China. A total of 132 confirmed cases and 39 deaths have been reported. Most patients presented with severe pneumonia and acute respiratory distress syndrome. Although the first epidemic has subsided, the presence of a natural reservoir and the disease severity highlight the need to evaluate its risk on human public health and to understand the possible pathogenesis mechanism. Here we show that the emerging H7N9 avian influenza virus poses a potentially high risk to humans. We discover that the H7N9 virus can bind to both avian-type (α2,3-linked sialic acid) and human-type (α2,6-linked sialic acid) receptors. It can invade epithelial cells in the human lower respiratory tract and type II pneumonocytes in alveoli, and replicated efficiently in ex vivo lung and trachea explant culture and several mammalian cell lines. In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected. We note that the human population is naive to the H7N9 virus, and current seasonal vaccination could not provide protection.
339 citations
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TL;DR: The sex ratios in urban compared with rural cases are consistent with exposure to poultry driving the risk of infection--a higher risk in men was only recorded in urban areas but not in rural areas, and the increased risk for men was of a similar magnitude for H7N9 and H5N1.
281 citations
Authors
Showing all 2403 results
Name | H-index | Papers | Citations |
---|---|---|---|
Feng Zhang | 172 | 1278 | 181865 |
Yang Yang | 171 | 2644 | 153049 |
Lei Zhang | 135 | 2240 | 99365 |
Jian Zhang | 107 | 3064 | 69715 |
Wei Wang | 95 | 3544 | 59660 |
Jie Li | 76 | 843 | 32221 |
Jing Liu | 73 | 1351 | 27169 |
Haidong Kan | 71 | 405 | 44210 |
Wei Wang | 66 | 673 | 20023 |
Jin-Tai Yu | 66 | 439 | 20020 |
Qi Jin | 64 | 335 | 45892 |
Chuan Qin | 60 | 326 | 21708 |
Ji-Sheng Han | 60 | 339 | 13660 |
Ying Zhou | 60 | 663 | 14349 |
Jun Huang | 57 | 445 | 12176 |