Institution
National Institute for Medical Research
Facility•
About: National Institute for Medical Research is a based out in . It is known for research contribution in the topics: Population & Antigen. The organization has 8407 authors who have published 13455 publications receiving 908225 citations. The organization is also known as: NIMR.
Topics: Population, Antigen, Gene, Virus, Plasmodium falciparum
Papers published on a yearly basis
Papers
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TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Abstract: Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.
11,123 citations
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TL;DR: A new method for multiple sequence alignment that provides a dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most commonly used alternatives but avoids the most serious pitfalls caused by the greedy nature of this algorithm.
6,727 citations
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TL;DR: Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA, and the transformed cells exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen.
Abstract: Summary Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA. The transformed cells (designated 293 cells) exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen. Analysis of the polypeptides synthesized in the 293 cells by labelling with 35S-methionine and SDS PAGE showed a variable pattern of synthesis, different in a number of respects from that seen in other human cells. On labelling the surface of cells by lactoperoxidase catalysed radio-iodination, the absence of a labelled polypeptide analogous to the 250 K (LETS) glycoprotein was noted. Hybridization of labelled cellular RNA with restriction fragments of adenovirus type 5 DNA indicated transcription of a portion of the adenovirus genome at the conventional left hand end.
5,243 citations
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TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
3,711 citations
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TL;DR: During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released.
Abstract: During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.
2,849 citations
Authors
Showing all 8412 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard A. Flavell | 231 | 1328 | 205119 |
Andrew P. McMahon | 162 | 415 | 90650 |
Pete Smith | 156 | 2464 | 138819 |
Richard O. Hynes | 143 | 442 | 97442 |
Clifford J. Woolf | 141 | 509 | 86164 |
Kenneth M. Yamada | 139 | 446 | 72136 |
Timothy J. Mitchison | 133 | 404 | 66418 |
Alan Sher | 132 | 486 | 68128 |
Brigid L.M. Hogan | 132 | 333 | 66486 |
David Taylor | 131 | 2469 | 93220 |
Janet M. Thornton | 130 | 539 | 105144 |
Mark H. Ginsberg | 127 | 474 | 57011 |
Martin Raff | 125 | 344 | 54567 |
Stephen C. Harrison | 123 | 420 | 59495 |
Michael J. Kuhar | 121 | 573 | 55398 |