Institution
National Institute of Advanced Industrial Science and Technology
Government•Tsukuba, Ibaraki, Japan•
About: National Institute of Advanced Industrial Science and Technology is a government organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 22114 authors who have published 65856 publications receiving 1669827 citations. The organization is also known as: Sangyō Gijutsu Sōgō Kenkyū-sho.
Topics: Catalysis, Thin film, Carbon nanotube, Hydrogen, Laser
Papers published on a yearly basis
Papers
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TL;DR: In the case of ferromagnetic Heusler alloys Ni2+xMn1-xGa single crystals, a reversible strain of 6% was obtained in fields of 1 T.
Abstract: In ferromagnetic alloys with shape memory large reversible strains can be obtained by rearranging the martensitic domain structure by a magnetic field. Magnetization through displacement of domain walls is possible in the presence of high magnetocrystalline anisotropy, when martensitic structure rearrangement is energetically favorable compared to the reorientation of magnetic moments. In ferromagnetic Heusler alloys Ni2+xMn1–xGa the Curie temperature exceeds the martensitic transformation temperature. The fact that these two temperatures are close to room temperature offers the possibility of magnetically controlling the shape and size of ferromagnets in the martensitic state. In Ni2+xMn1–xGa single crystals, a reversible strain of ~6% is obtained in fields of ~1 T.
265 citations
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TL;DR: Bach2 is defined as a key regulator of antibody response and an insight into the orchestration of CSR and SHM during plasma cell differentiation is provided.
Abstract: Activated B cells differentiate to plasma cells to secrete IgM or, after undergoing class switch recombination (CSR), to secrete other classes of immunoglobulins1,2,3,4. Diversification of antibody function by CSR is important for humoral immunity. However, it remains unclear how the decision for the bifurcation is made. Bach2 is a B-cell-specific transcription repressor interacting with the small Maf proteins whose expression is high only before the plasma cell stage5,6,7. Here we show that Bach2 is critical for CSR and somatic hypermutation (SHM)2,4,8 of immunoglobulin genes. Genetic ablation of Bach2 in mice revealed that Bach2 was required for both T-cell-independent and T-cell-dependent IgG responses and SHM. When stimulated in vitro, Bach2-deficient B cells produced IgM, as did wild-type cells, and abundantly expressed Blimp-1 (refs 9, 10) and XBP-1 (ref. 11), critical regulators of the plasmacytic differentiation12, indicating that Bach2 was not required for the plasmacytic differentiation itself. However, they failed to undergo efficient CSR. These findings define Bach2 as a key regulator of antibody response and provide an insight into the orchestration of CSR and SHM during plasma cell differentiation.
265 citations
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20 Apr 2002TL;DR: The new Cognitive Walkthrough for the Web (CWW) is superior for evaluating how well websites support users' navigation and information search tasks.
Abstract: This paper proposes a transformation of the Cognitive Walkthrough (CW), a theory-based usability inspection method that has proven useful in designing applications that support use by exploration. The new Cognitive Walkthrough for the Web (CWW) is superior for evaluating how well websites support users' navigation and information search tasks. The CWW uses Latent Semantic Analysis to objectively estimate the degree of semantic similarity (information scent) between representative user goal statements (100-200 words) and heading/link texts on each web page. Using an actual website, the paper shows how the CWW identifies three types of problems in web page designs. Three experiments test CWW predictions of users' success rates in accomplishing goals, verifying the value of CWW for identifying these usability problems
264 citations
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TL;DR: It is concluded that the UUG codon-specific translational defect of the mutant mt tRNAs(Leu(UUR)) is the primary cause of MELAS at the molecular level.
Abstract: Point mutations in the mitochondrial (mt) tRNALeu(UUR) gene are responsible for mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a subgroup of mitochondrial encephalomyopathic diseases. We previously showed that mt tRNALeu(UUR) with an A3243G or T3271C mutation derived from patients with MELAS are deficient in a normal taurine-containing modification (τm5U; 5-taurinomethyluridine) at the anticodon wobble position. To examine decoding disorder of the mutant tRNA due to the wobble modification deficiency independent of the pathogenic point mutation itself, we used a molecular surgery technique to construct an mt tRNALeu(UUR) molecule lacking the taurine modification but without the pathogenic mutation. This “operated” mt tRNALeu(UUR) without the taurine modification showed severely reduced UUG translation but no decrease in UUA translation. We thus concluded that the UUG codon–specific translational defect of the mutant mt tRNAsLeu(UUR) is the primary cause of MELAS at the molecular level. This result could explain the complex I deficiency observed clinically in MELAS.
264 citations
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TL;DR: In this paper, the fluorescence and phosphorescence quantum yields of standard solutions have been re-evaluated based on an absolute method using an integrating sphere equipped with a multichannel spectrometer.
264 citations
Authors
Showing all 22289 results
Name | H-index | Papers | Citations |
---|---|---|---|
Takeo Kanade | 147 | 799 | 103237 |
Ferenc A. Jolesz | 143 | 631 | 66198 |
Michele Parrinello | 133 | 637 | 94674 |
Kazunari Domen | 130 | 908 | 77964 |
Hideo Hosono | 128 | 1549 | 100279 |
Hideyuki Okano | 128 | 1169 | 67148 |
Kurunthachalam Kannan | 126 | 820 | 59886 |
Shaobin Wang | 126 | 872 | 52463 |
Ajit Varki | 124 | 542 | 58772 |
Tao Zhang | 123 | 2772 | 83866 |
Ramamoorthy Ramesh | 122 | 649 | 67418 |
Kazuhito Hashimoto | 120 | 781 | 61195 |
Katsuhiko Mikoshiba | 120 | 866 | 62394 |
Qiang Xu | 117 | 585 | 50151 |
Yoshinori Tokura | 117 | 858 | 70258 |