National Institute of Technology, Meghalaya

About: National Institute of Technology, Meghalaya is a education organization based out in Shillong, India. It is known for research contribution in the topics: Control theory & Electric power system. The organization has 503 authors who have published 1062 publications receiving 6818 citations. The organization is also known as: NIT Meghalaya & NITM.

Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies.

Abstract: In recent years research based on kaempferol (KMP) has shown its potential therapeutic applications in medicinal chemistry and clinical biology. Therefore, to understand its molecular recognition mechanism, we studied its interactions with the carrier proteins, namely, human serum albumin (HSA), bovine hemoglobin (BHb) and hen egg white lysozyme (HEWL). The ligand, KMP was able to quench the intrinsic fluorescence of these three proteins efficiently through static quenching mode. The binding constant (Kb) for the interactions of KMP with these three proteins were found in the following order: HSA-KMP > BHb-KMP > HEWL-KMP. Different non-covalent forces such as hydrogen bonding and hydrophobic forces played a major role in the binding of KMP with HSA and HEWL, whereas hydrogen bonding and van der Waals forces contribute to the complexation of BHb with KMP. KMP was able to alter the micro-environment near the Trp fluorophore of the proteins. KMP altered the secondary structural component of all three proteins. The putative binding sites and the residues surrounding the KMP molecule within the respective protein matrix were determined through molecular docking and molecular dynamics (MD) simulation studies. The conformational flexibility of the ligand KMP and the three individual proteins were also evident from the MD simulation studies.

A Role of Side-Chain Regiochemistry of Thienylene–Vinylene–Thienylene (TVT) in the Transistor Performance of Isomeric Polymers

Abstract: The π-extended (E)-2-(2-(thiophen-2-yl)-vinyl)thiophene (TVT)-based polymers are an interesting class of semiconducting polymers because of their excellent mobilities and unique film microstructures. Despite these properties, the effect of the side-chain regiochemistry of TVT skeletons on the intrinsic properties of these polymers remains unclear. To investigate this, in this study, hexyl-substituted TVT subunits with a “tail in (TI)” or “tail out (TO)” regiosymmetrical arrangement were first introduced into diketopyrrolopyrrole (DPP)-based copolymer main chains to afford “isomeric” polymers PI and PO, respectively. By combining optical spectroscopy, atomic force microscopy (AFM), and grazing incidence X-ray diffraction (GIXD) data, we quantitatively characterized the aggregation, crystallization, and backbone orientation of both polymer films, which were then correlated to the charge-carrier mobilities. The PI film exhibited a bimodal packing motif comprising a mixture of edge-on and face-on orientations...

Enhancing User Identity Privacy in LTE

Abstract: Identity privacy is a security issue that is crucial for the users of a cellular network. Knowledge of the permanent identity of a user may allow an adversary to track and amass comprehensive profiles about individuals. Such profiling may expose an individual to various kind of unanticipated risks, and above all may deprive an individual of his right to privacy. With the introduction of sensitive services like online banking, shopping, etc. through cellular phones, identity privacy has now become a bigger security issue. In GSM and UMTS, the problem of user identity privacy vulnerability is proven to exist. In both these systems, there are situations where the permanent identity of a subscriber may get compromised. Long Term Evolution (LTE), which evolved from GSM and UMTS, is proposed by 3GPP for inclusion into the fourth generation of cellular networks. Although security of LTE has evolved from the security of GSM and UMTS, due to different architectural and business requirements of fourth generation systems, LTE security is substantially different and improved compared to its predecessors. However, the issue of identity privacy vulnerability continue to exist in LTE. In this paper, we discuss how the security architecture of LTE deals with identity privacy. We also discuss a possible solution that may be utilised to overcome the problem of user identity privacy in LTE.