scispace - formally typeset
Search or ask a question
Institution

National Jewish Health

HealthcareDenver, Colorado, United States
About: National Jewish Health is a healthcare organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: T cell & Asthma. The organization has 883 authors who have published 833 publications receiving 79201 citations. The organization is also known as: National Jewish Medical and Research Center.
Topics: T cell, Asthma, Population, Lung, Antigen


Papers
More filters
Patent
10 Sep 2010
TL;DR: In this article, a vial holder is provided to protect a user's hand from needle sticks, which includes a handle and a shield attached to a distal end of the handle.
Abstract: A vial holder is provided to protect a user's hand from needle sticks. The holder includes a handle and a shield attached to a distal end of the handle. An opening is formed in the distal end of the handle to receive a vial. The vial is placed through the opening and into a passageway of the handle with the upper end of the vial exposed. A user grasps the handle which holds the vial in a stabilized manner. A needle may then safely approach the vial in which inadvertent slippage or movement of the needle results in contact with the needle against the shield and not contact with the user's hand.

8 citations

Journal Article
TL;DR: There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in patients and the combination was shown to produce greater and longer lasting bronchodilation than either drug alone.
Abstract: The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the "morning dipping" in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.

8 citations

Journal ArticleDOI
TL;DR: It is concluded that the immune abnormalities in hemophiliacs are the result of contact with HTLV-III but that these abnormalities may remain stable over prolonged periods.
Abstract: Twenty-nine heterosexual patients with hemophilia were investigated with histories, physical examinations, laboratory evaluations of immune function, delayed hypersensitivity skin tests, and assays for antibody to human T-cell lymphotropic virus type III (HTLV-III). Sixteen patients were HTLV-III antibody positive and 13 were HTLV-III antibody negative. No patient had the acquired immune deficiency syndrome (AIDS). Patients who had antibody to HTLV-III had received significantly more units and lots of factor concentrates in the preceding 5 years than those who did not have antibody. HTLV-III antibody-positive patients had significantly fewer total T cells (Leu-1 positive) and significantly fewer helper T cells (Leu-3 positive) than HTLV-III negative patients. Antibody-positive patients also had increased amounts of IgG and decreased thymidine incorporation in response to concanavalin Ain vitro. There were no differences inin vitro lymphocyte responses to phytohemagglutinin (PHA), pokeweed mitogen,Candida, tetanus, or purified protein derivative (PPD), no significant impairments of gamma interferon or interleukin-2 (IL-2) production, and no anergy. Ten patients with antibody to HTLV-III had immunologic studies repeated 1 year after the original evaluation. A significant increase was seen in suppressor (Leu-2-positive) T cells but not in total T-cell or helper T-cell numbers, helper/suppressor ratios, or T-cell functional assays. We conclude that the immune abnormalities in hemophiliacs are the result of contact with HTLV-III but that these abnormalities may remain stable over prolonged periods.

8 citations

Journal ArticleDOI
TL;DR: Improvement in parent quality of life was predicted by perception of illness burden, whereas family features and a child missing school predicted moderate decline, and subclinical levels of depression predicted moderate improvement in child-reportedquality of life.
Abstract: To determine factors associated with 24-month change in quality of life in children with asthma and their parents during the Childhood Asthma Management Program (CAMP). Participants from 4 CAMP clinical centers were administered the Pediatric Asthma Quality of Life questionnaire and protocol measures of asthma symptoms, lung function, and psychological measures. Multivariate logistic regression analyses determined predictors of moderate change in quality of life. Subclinical levels of depression predicted moderate improvement in child-reported quality of life. Level of depressed affect together with clinical asthma features predicted moderate decline. Improvement in parent quality of life was predicted by perception of illness burden, whereas family features and a child missing school predicted moderate decline. This ancillary study provided an opportunity to examine the determinants of 24-month change in parent and child of quality of life within a subset of the CAMP participants. Moderate changes in quality of life occur in clinical studies and have both psychosocial correlates and illness characteristics.

7 citations


Authors

Showing all 901 results

NameH-indexPapersCitations
Thomas V. Colby12650160130
John W. Kappler12246457541
Donald Y.M. Leung12161450873
Philippa Marrack12041654345
Jeffrey M. Drazen11769352493
Peter M. Henson11236954246
David A. Schwartz11095853533
David A. Lynch10871459678
Norman R. Pace10129750252
Kevin K. Brown10038747219
Stanley J. Szefler9955437481
Erwin W. Gelfand9967536059
James D. Crapo9847337510
Yang Xin Fu9739033526
Stephen D. Miller9443330499
Network Information
Related Institutions (5)
National Institutes of Health
297.8K papers, 21.3M citations

91% related

Johns Hopkins University School of Medicine
79.2K papers, 4.7M citations

91% related

University of Texas Southwestern Medical Center
75.2K papers, 4.4M citations

91% related

Baylor College of Medicine
94.8K papers, 5M citations

91% related

Icahn School of Medicine at Mount Sinai
76K papers, 3.7M citations

90% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202214
202113
202017
201917
201841