National Jewish Health

About: National Jewish Health is a healthcare organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Asthma & T cell. The organization has 883 authors who have published 833 publications receiving 79201 citations. The organization is also known as: National Jewish Medical and Research Center.

Immunosuppressive Management of Cardiac Sarcoidosis

Abstract: Sarcoidosis is a multi-system granulomatous disorder of yet unknown etiology that predominantly involves the lungs in over 90 % of cases but can also involve any organ in the body. Cardiac sarcoidosis is detected clinically in about 5 % of patients with sarcoidosis but on autopsy in as many as 40 % suggesting that the majority of cases may be underdiagnosed. Complications of cardiac sarcoidosis can include ventricular dysfunction, conduction abnormalities, ventricular arrhythmias and sudden cardiac death. These may occur suddenly, without warning in a previously asymptomatic or undiagnosed patient. There are currently no guidelines on how to definitively manage cardiac sarcoidosis. The goal of immunosuppressive (IS) therapy in cardiac sarcoidosis is to reverse any ongoing active granulomatous myocarditis, potentially prevent progression of myocardial granulomatous inflammation to scar tissue, and reduce or prevent the development of serious or life threatening cardiac complications. Management of cardiac sarcoidosis requires the collaborative effort of a sarcoidosis expert, an electrophysiologist, and a general cardiologist.

Efficacy and safety of standardized short ragweed sublingual immunotherapy tablet (SLIT-T) treatment in Canadian subjects with ragweed pollen-induced rhinitis with or without conjunctivitis

Abstract: Background Efficacy of standardized short ragweed sublingual immunotherapy tablet (SLIT-T), MK-3641 (Merck/ALK; 12 Amb a 1-U of Ambrosia artemisiifolia) treatment on Canadian ragweed-allergic subjects was assessed using subgroup analysis of data from 2 multinational, randomized, double-blind, placebo-controlled clinical trials designed to evaluate ragweed SLIT-T efficacy and safety in adults with ragweed pollen-induced allergic rhinitis with or without conjunctivitis (AR/C), with or without asthma.

Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing

Abstract: Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing John Brothers II, Rebecca Kusko, Gang Liu, Lingqi Luo, Brenda Juan Guardela, John Tedrow, Yuriy Alekesyev, Ivana V Yang, Mick Correll, Mark Geraci, John Quackenbush, Frank Sciurba, Paola Sebastiani, Marc Lenburg, Naftali Kaminski, David A Schwartz, Avrum Spira, Jennifer Beane

CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation

Abstract: Asthma is a complex syndrome involving many cell types, effector molecules, and mediators. CD4+ T cells are known to play a pivotal role in the initiation of the disease. Here, the role of the CD8+ T cells is highlighted, both in the triggering of lung allergic responses and in the negative regulation of these responses.

Evaluation of Lung Disease in Patients with Connective Tissue Disease

Abstract: Lung disease is a common manifestation of connective tissue disease (CTD) and is associated with significant morbidity and mortality. The evaluation of lung disease, and interstitial lung disease (ILD) in particular, in patients with CTD is complex because of the heterogeneity of the CTDs and the varied types and degrees of severity of ILD encountered and because ILD can be identified at any point in time in these patients. A thorough—and multidisciplinary—evaluation is needed when CTD patients develop ILD or when evaluating ILD patients for the presence of occult CTD. Determining that ILD is associated with an established CTD requires the exclusion of alternative etiologies and thorough assessments of the clinical features of both the CTD and ILD. The detection of occult CTD in patients with so-called “idiopathic” ILD requires careful attention to the demographic profile, historical clues, subtle physical examination findings, specific autoantibody positivity, and radiologic and histopathologic features and can be optimized by a multidisciplinary approach that includes rheumatologic collaboration. A standardized assessment with the serial implementation of objective tests to determine disease severity and evidence of progression is important for the longitudinal monitoring of patients with CTD-associated ILD and helps guide management considerations.