National Jewish Health

About: National Jewish Health is a healthcare organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Asthma & T cell. The organization has 883 authors who have published 833 publications receiving 79201 citations. The organization is also known as: National Jewish Medical and Research Center.

Mental Health of Rural Young Adults: Prevalence of Psychiatric Disorders, Comorbidity, and Service Utilization

Abstract: Few studies estimate rural psychiatric disorder rates. No study has reported either DSM-III-R or DSM IV disorder prevalence and mental health service use among US rural young adults. This paper reports psychiatric disorder prevalence, comorbidity, service utilization, and disorder correlates in a community sample of 536 young adults, aged 19 to 23 years, living in the rural Midwestern US. More than 60% of the sample met criteria for a lifetime disorder. Substance use disorders were most prevalent. Results indicate that young adults living in the rural Midwest demonstrate substantial rates of psychiatric disorder that are comparable to other population groups.

What's the Connection?

Abstract: A 26-year-old white man presented to our referral hospital with a 1-month history of persistent cough productive of white sputum, which was occasionally tinged with blood. He reported mild pleuritic chest pain but no dyspnea, fever, chills, night sweats, or weight loss. The patient had had no epistaxis or episodes of sinusitis. One week before presentation, his cough had been treated with an empirical course of azithromycin with no resolution of his symptoms. A key feature when evaluating a patient with cough is symptom duration. Acute cough lasts less than 3 weeks and is usually caused by a respiratory tract infection. Cough lasting longer than 8 weeks is considered chronic and is most often due to postnasal drip, asthma, or gastroesophageal reflux disease. Hemoptysis, however, suggests diseases of the airways — particularly bronchitis and bronchiectasis, although other causes must also be considered. A young man is unlikely to have bronchogenic carcinoma, although he could have metastatic testicular cancer or bronchial carcinoid. Kaposi’s sarcoma involving the airways may cause hemoptysis in patients infected with the human immunodeficiency virus (HIV). Hemoptysis can also arise from the lung parenchyma. Autoimmune disease, cocaine inhalation, and infections (including tuberculosis, bacterial pneumonia, and lung abscess) are potential culprits. A last consideration is that hemoptysis can arise from the pulmonary vasculature as a result of pulmonary embolism, pulmonary arteriovenous malformation, mitral stenosis, and severe left heart failure. Five years before this presentation, the patient had been treated for a right-sided spontaneous pneumothorax. At that time, his hospital course was complicated by multiple chest-tube insertions on the right side, thoracotomy, and pleurodesis. Three years before presentation, he had had left-sided flank pain and was found to have a spontaneous left renal-artery dissection with renal infarction. He had received care elsewhere, and medical records were not available. The patient worked as a graphic designer. He was monogamous and had no risk factors for infection with HIV. He neither smoked nor used illicit drugs. His outpatient medications consisted only of a multivitamin. His mother died at 52 years of age from a presumed pulmonary embolus; the family history was otherwise unremarkable.

Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.

Abstract: Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresp