National Research University – Higher School of Economics

About: National Research University – Higher School of Economics is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Population & Politics. The organization has 12873 authors who have published 23376 publications receiving 256396 citations.

Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.

Abstract: Numerous physiological functions rely on distinguishing temperature through temperature-sensitive transient receptor potential channels (thermo-TRPs). Although the function of thermo-TRPs has been studied extensively, structural determination of their heat- and cold-activated states has remained a challenge. Here, we present cryo-EM structures of the nanodisc-reconstituted wild-type mouse TRPV3 in three distinct conformations: closed, heat-activated sensitized and open states. The heat-induced transformations of TRPV3 are accompanied by changes in the secondary structure of the S2-S3 linker and the N and C termini and represent a conformational wave that links these parts of the protein to a lipid occupying the vanilloid binding site. State-dependent differences in the behavior of bound lipids suggest their active role in thermo-TRP temperature-dependent gating. Our structural data, supported by physiological recordings and molecular dynamics simulations, provide an insight for understanding the molecular mechanism of temperature sensing. Cryo-EM structures of the heat-activated TRP channel TRPV3 in lipid nanodiscs at different temperatures reveal a conformational wave involved in the gating process.

Revisiting the Sustainable Happiness Model and Pie Chart: Can Happiness Be Successfully Pursued?

Abstract: The Sustainable Happiness Model (SHM) has been influential in positive psychology and well-being science. However, the ‘pie chart’ aspect of the model has received valid critiques. In this article,...

Monetary policy and the financial accelerator in a monetary union

Abstract: In this paper, we consider the effect of a monetary union in a model with a significant role for financial market imperfections We do so by introducing a financial accelerator into a stochastic general equilibrium macro model of a two country economy We show that financial market imperfections introduce important cross-country transmission mechanisms to asymmetric shocks to supply and demand Within this framework, we study the likely costs and benefits of monetary union We also consider the effects of cross-country heterogeneity in financial markets Both the presence of financial frictions and the use of a single currency have significant impacts on the international propagation of exogenous shocks The introduction of asymmetries in the financial contract widens the differences in cyclical behavior of national economies in a monetary union, but financial integration compensates the loss of policy instruments

Gushel--Mukai varieties: classification and birationalities

Abstract: We perform a systematic study of Gushel-Mukai varieties---quadratic sections of linear sections of cones over the Grassmannian Gr(2,5). This class of varieties includes Clifford general curves of genus 6, Brill-Noether general polarized K3 surfaces of genus 6, prime Fano threefolds of genus 6, and their higher-dimensional analogues. We establish an intrinsic characterization of normal Gushel-Mukai varieties in terms of their excess conormal sheaves, which leads to a new proof of the classification theorem of Gushel and Mukai. We give a description of isomorphism classes of Gushel-Mukai varieties and their automorphism groups in terms of linear algebraic data naturally associated to these varieties. We carefully develop the relation between Gushel-Mukai varieties and Eisenbud-Popescu-Walter sextics introduced earlier by Iliev-Manivel and O'Grady. We describe explicitly all Gushel-Mukai varieties whose associated EPW sextics are isomorphic or dual (we call them period partners or dual varieties respectively). Finally, we show that in dimension 3 and higher, period partners/dual varieties are always birationally isomorphic.