National Research University – Higher School of Economics

About: National Research University – Higher School of Economics is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Population & Computer science. The organization has 12873 authors who have published 23376 publications receiving 256396 citations.

Biopolitics and Power in Putin’s Russia

Abstract: In Putin’s third term, official rhetoric has become a normative, moralizing discourse promoting Russian traditional values as opposed to the “moral decay” of the West. This “biopolitical turn” in Russian politics–a redefining of the boundaries of the Russian political community and extension of state sovereignty into private lives–is part of the authoritarian drift of the Russian political regime.

[Virus-Like Particles as an Instrument of Vaccine Production].

Abstract: The paper discusses the techniques which are currently implemented for vaccine production based on virus-like particles (VLPs). The factors which determine the characteristics of VLP monomers assembly are provided in detail. Analysis of the literature demonstrates that the development of the techniques of VLP production and immobilization of target antigens on their surface have led to the development of universal platforms which make it possible for virtually any known antigen to be exposed on the particle surface in a highly concentrated form. As a result, the focus of attention has shifted from the approaches to VLP production to the development of a precise interface between the organism's immune system and the peptides inducing a strong immune response to pathogens or the organism's own pathological cells. Immunome-specified methods for vaccine design and the prospects of immunoprophylaxis are discussed. Certain examples of vaccines against viral diseases and cancers are considered.

Winning by Losing: Incentive Incompatibility in Multiple Qualifiers

Abstract: In sport tournaments, the rules are presumably structured in a way that any participant cannot benefit by losing instead of winning. We show that tournament systems, consisting of multiple round-robin and knockout tournaments with noncumulative prizes, which are ubiquitous around the world, are generically incentive incompatible. We use our model to discuss potential remedies and applications.

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

Abstract: Regulatory T cells (Treg cells), whose differentiation and function are controlled by transcription factor Foxp3, express the closely related family member Foxp1. Here we explored Foxp1 function in Treg cells. We found that a large number of Foxp3-bound genomic sites in Treg cells were occupied by Foxp1 in both Treg cells and conventional T cells (Tconv cells). In Treg cells, Foxp1 markedly increased Foxp3 binding to these sites. Foxp1 deficiency in Treg cells resulted in their impaired function and competitive fitness, associated with markedly reduced CD25 expression and interleukin-2 (IL-2) responsiveness, diminished CTLA-4 expression and increased SATB1 expression. The characteristic expression patterns of CD25, Foxp3 and CTLA-4 in Treg cells were fully or partially rescued by strong IL-2 signaling. Our studies suggest that Foxp1 serves an essential non-redundant function in Treg cells by enforcing Foxp3-mediated regulation of gene expression and enabling efficient IL-2 signaling in these cells.