National Research University – Higher School of Economics

About: National Research University – Higher School of Economics is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Population & Politics. The organization has 12873 authors who have published 23376 publications receiving 256396 citations.

Political Culture and Democracy: Analyzing Crosslevel Linkages

Abstract: Do individual-level attitudes play a significant role in sustaining democratic institutions at the societal level? In a recent article in Comparative Politics, Seligson argued that the strong aggregate-level correlations Inglehart found between political culture and stable democracy were spurious because there are no individual-level correlations between political culture and overt support for democracy. Seligson's analysis exemplifies the sort of cross-level fallacy he attributes to Inglehart: he equates individual-level support for democracy with the presence of democratic institutions. However, individual-level support of democracy is only weakly linked with societal-level democracy. Democracy currently has a positive image almost everywhere, but favorable opinions are often superficial. Unless they are accompanied by more deeply rooted orientations of tolerance, trust, and participation, chances for effective democracy are poor.

tcR: an R package for T cell receptor repertoire advanced data analysis

Abstract: The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in antigen recognition during the adaptive immune response. Recent progress in next-generation sequencing technologies has provided an opportunity for the deep T cell receptor repertoire profiling. However, a specialised software is required for the rational analysis of massive data generated by next-generation sequencing. Here we introduce tcR, a new R package, representing a platform for the advanced analysis of T cell receptor repertoires, which includes diversity measures, shared T cell receptor sequences identification, gene usage statistics computation and other widely used methods. The tool has proven its utility in recent research studies. tcR is an R package for the advanced analysis of T cell receptor repertoires after primary TR sequences extraction from raw sequencing reads. The stable version can be directly installed from The Comprehensive R Archive Network ( http://cran.r-project.org/mirrors.html ). The source code and development version are available at tcR GitHub ( http://imminfo.github.io/tcr/ ) along with the full documentation and typical usage examples.

Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models.

Abstract: Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties. Generated structures can be utilized for virtual screening or training semi-supervized predictive models in the downstream tasks. While there are plenty of generative models, it is unclear how to compare and rank them. In this work, we introduce a benchmarking platform called Molecular Sets (MOSES) to standardize training and comparison of molecular generative models. MOSES provides training and testing datasets, and a set of metrics to evaluate the quality and diversity of generated structures. We have implemented and compared several molecular generation models and suggest to use our results as reference points for further advancements in generative chemistry research. The platform and source code are available at https://github.com/molecularsets/moses.

An SEM Approach to Continuous Time Modeling of Panel Data: Relating Authoritarianism and Anomia

Abstract: Panel studies, in which the same subjects are repeatedly observed at multiple time points, are among the most popular longitudinal designs in psychology. Meanwhile, there exists a wide range of different methods to analyze such data, with autoregressive and cross-lagged models being 2 of the most well known representatives. Unfortunately, in these models time is only considered implicitly, making it difficult to account for unequally spaced measurement occasions or to compare parameter estimates across studies that are based on different time intervals. Stochastic differential equations offer a solution to this problem by relating the discrete time model to its underlying model in continuous time. It is the goal of the present article to introduce this approach to a broader psychological audience. A step-by-step review of the relationship between discrete and continuous time modeling is provided, and we demonstrate how continuous time parameters can be obtained via structural equation modeling. An empirical example on the relationship between authoritarianism and anomia is used to illustrate the approach.