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Institution

National Taiwan University

EducationTaipei, Taipei, Taiwan
About: National Taiwan University is a education organization based out in Taipei, Taipei, Taiwan. It is known for research contribution in the topics: Population & Cancer. The organization has 85071 authors who have published 130866 publications receiving 3365464 citations. The organization is also known as: NTU.
Topics: Population, Cancer, CMOS, Thin film, Hazard ratio


Papers
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Journal ArticleDOI
19 Nov 2015-Nature
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
Abstract: Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins α6β4 and α6β1 were associated with lung metastasis, while exosomal integrin αvβ5 was linked to liver metastasis. Targeting the integrins α6β4 and αvβ5 decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.

3,399 citations

Journal ArticleDOI
TL;DR: In patients with unresectable hepatocellular carcinoma, atezolIZumab combined with bevacizumab resulted in better overall and progression-free survival outcomes than sorafenib.
Abstract: Background The combination of atezolizumab and bevacizumab showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable hepatocellular carcinom...

3,085 citations

Journal ArticleDOI
Jeffrey D. Stanaway1, Ashkan Afshin1, Emmanuela Gakidou1, Stephen S Lim1  +1050 moreInstitutions (346)
TL;DR: This study estimated levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs) by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017 and explored the relationship between development and risk exposure.

2,910 citations


Authors

Showing all 85397 results

NameH-indexPapersCitations
P. Chang1702154151783
Lex M. Bouter158767103034
Thomas S. Huang1461299101564
Rafi Ahmed14663393190
Ming T. Tsuang14088573865
S. R. Hou1391845106563
Claude Amsler1381454135063
Bin Liu138218187085
Y. B. Hsiung138125894278
Shu Li136100178390
Peter Robmann135143897569
Chia-Ming Kuo132124990067
Yueh-Feng Liu13183174698
Gulsen Onengut131123284686
John Paul Chou131119382912
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023169
2022595
20216,819
20206,717
20196,292
20185,746