Institution
National University of La Plata
Education•La Plata, Argentina•
About: National University of La Plata is a education organization based out in La Plata, Argentina. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 12993 authors who have published 30013 publications receiving 495118 citations. The organization is also known as: UNLP & Universidad Nacional de La Plata.
Topics: Population, Large Hadron Collider, Stars, White dwarf, Catalysis
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TL;DR: The data suggest that, by globally regulating lipid metabolism, stearoyl-CoA desaturase activity modulates cell proliferation and survival and emphasize the important role of endogenously synthesized monounsaturated fatty acids in sustaining the neoplastic phenotype of transformed cells.
156 citations
TL;DR: By studying the sleep EEG in patients with focal epilepsies, Frauscher et al. show that the increase in discharges is specifically associated with high-amplitude slow waves, which occurs at transitions from activation to deactivation states, a period of high synchronization.
Abstract: Epileptic discharges in focal epilepsy are frequently activated during non-rapid eye movement sleep. Sleep slow waves are present during this stage and have been shown to include a deactivated ('down', hyperpolarized) and an activated state ('up', depolarized). The 'up' state enhances physiological rhythms, and we hypothesize that sleep slow waves and particularly the 'up' state are the specific components of non-rapid eye movement sleep that mediate the activation of epileptic activity. We investigated eight patients with pharmaco-resistant focal epilepsies who underwent combined scalp-intracerebral electroencephalography for diagnostic evaluation. We analysed 259 frontal electroencephalographic channels, and manually marked 442 epileptic spikes and 8487 high frequency oscillations during high amplitude widespread slow waves, and during matched control segments with low amplitude widespread slow waves, non-widespread slow waves or no slow waves selected during the same sleep stages (total duration of slow wave and control segments: 49 min each). During the slow waves, spikes and high frequency oscillations were more frequent than during control segments (79% of spikes during slow waves and 65% of high frequency oscillations, both P ∼ 0). The spike and high frequency oscillation density also increased for higher amplitude slow waves. We compared the density of spikes and high frequency oscillations between the 'up' and 'down' states. Spike and high frequency oscillation density was highest during the transition from the 'up' to the 'down' state. Interestingly, high frequency oscillations in channels with normal activity expressed a different peak at the transition from the 'down' to the 'up' state. These results show that the apparent activation of epileptic discharges by non-rapid eye movement sleep is not a state-dependent phenomenon but is predominantly associated with specific events, the high amplitude widespread slow waves that are frequent, but not continuous, during this state of sleep. Both epileptic spikes and high frequency oscillations do not predominate, like physiological activity, during the 'up' state but during the transition from the 'up' to the 'down' state of the slow wave, a period of high synchronization. Epileptic discharges appear therefore more associated with synchronization than with excitability. Furthermore, high frequency oscillations in channels devoid of epileptic activity peak differently during the slow wave cycle from those in channels with epileptic activity. This property may allow differentiating physiological from pathological high frequency oscillations, a problem that is unresolved until now.
156 citations
TL;DR: Gomez et al. as discussed by the authors presented a study on the role of the radio frequency in the discovery of the EKF in the Alemana project of the Max Planck Institut Fur Astrophysik.
Abstract: Fil: Gomez, Facundo A.. Gobierno de la Republica Federal de Alemania. Max Planck Institut Fur Astrophysik; Alemania. Michigan State University; Estados Unidos
155 citations
University of Sydney1, University of Auckland2, Charité3, Slovak Academy of Sciences4, Centre national de la recherche scientifique5, University of Florence6, University of Illinois at Chicago7, University of Hamburg8, National Institute of Occupational Health9, University of Tarapacá10, University at Albany, SUNY11, Boston University12, University of Cagliari13, Istituto Superiore di Sanità14, Environmental Defense Fund15, University of Cape Town16, Hebrew University of Jerusalem17, University of Toronto18, Drexel University19, East Carolina University20, University of Louisville21, Curtin University22, University of Queensland23, Virginia Tech24, University of Paris25, Netherlands Cancer Institute26, Peking University27, National Institutes of Health28, University of Florida29, Brunel University London30, German Cancer Research Center31, Utrecht University32, National University of La Plata33, Icahn School of Medicine at Mount Sinai34, Wayne State University35, University of Helsinki36, University of Iowa37, University of Eastern Piedmont38, Lancaster University39, National Health Service40, University of Turin41, City University of New York42, University of KwaZulu-Natal43, George Washington University44, Sapienza University of Rome45, Louisiana State University46, University of Arizona47, National Autonomous University of Nicaragua48, University of Basel49, Mississippi State University50, Florida International University51, Texas A&M University52, University of São Paulo53, Finnish Institute of Occupational Health54, Radboud University Nijmegen55, University of Alberta56, Johns Hopkins University57, University of California, Berkeley58, University of New South Wales59, University of California, San Francisco60, National Research Council61, Heidelberg University62, University of Washington63, Kuwait University64, Medical University of South Carolina65, Imperial College London66, University of Tromsø67, City of Hope National Medical Center68, Okayama University69, Hoseo University70, University of Padua71, Leibniz Association72, University of South Florida73
TL;DR: The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971.
Abstract: The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971. Monographs are written by ad hoc Working Groups (WGs) of international scientific experts over a period of about 12 months ending in an eight-day meeting. The WG evaluates all of the publicly available scientific information on each substance and, through a transparent and rigorous process,1 decides on the degree to which the scientific evidence supports that substance's potential to cause or not cause cancer in humans.
For Monograph 112,2 17 expert scientists evaluated the carcinogenic hazard for four insecticides and the herbicide glyphosate.3 The WG concluded that the data for glyphosate meet the criteria for classification as a probable human carcinogen .
The European Food Safety Authority (EFSA) is the primary agency of the European Union for risk assessments regarding food safety. In October 2015, EFSA reported4 on their evaluation of the Renewal Assessment Report5 (RAR) for glyphosate that was prepared by the Rapporteur Member State, the German Federal Institute for Risk Assessment (BfR). EFSA concluded that ‘glyphosate is unlikely to pose a carcinogenic hazard to humans and the evidence does not support classification with regard to its carcinogenic potential’. Addendum 1 (the BfR Addendum) of the RAR5 discusses the scientific rationale for differing from the IARC WG conclusion.
Serious flaws in the scientific evaluation in the RAR incorrectly characterise the potential for a carcinogenic hazard from exposure to glyphosate. Since the RAR is the basis for the European Food Safety Agency (EFSA) conclusion,4 it is critical that these shortcomings are corrected.
EFSA concluded ‘that there is very limited evidence for an association between glyphosate-based formulations …
155 citations
TL;DR: Searches for new resonances decaying into two photons in the ATLAS experiment at the CERN Large Hadron Collider are described in this article, based on protonproton collision data corresponding to two photons.
Abstract: Searches for new resonances decaying into two photons in the ATLAS experiment at the CERN Large Hadron Collider are described. The analysis is based on protonproton collision data corresponding to ...
155 citations
Authors
Showing all 13198 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David Cameron | 154 | 1586 | 126067 |
| Subir Sarkar | 149 | 1542 | 144614 |
| Mayda Velasco | 137 | 1309 | 87579 |
| Diego F. Torres | 137 | 948 | 72180 |
| Heidi Sandaker | 128 | 999 | 76517 |
| Vincent Garonne | 128 | 921 | 76980 |
| Farid Ould-Saada | 128 | 931 | 76394 |
| Ole Røhne | 128 | 1038 | 75752 |
| Peter Hansen | 128 | 1271 | 86210 |
| Maria-Teresa Dova | 127 | 778 | 73558 |
| Vladimir Sulin | 127 | 884 | 75329 |
| Andrei Snesarev | 127 | 875 | 74907 |
| James Catmore | 127 | 892 | 75086 |
| Ruslan Mashinistov | 126 | 860 | 73897 |
| Fernando Monticelli | 126 | 843 | 73385 |