Institution
National University of Malaysia
Education•Kuala Lumpur, Malaysia•
About: National University of Malaysia is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Heat transfer. The organization has 26593 authors who have published 41270 publications receiving 552683 citations. The organization is also known as: NUM & Universiti Kebangsaan Malaysia.
Topics: Population, Heat transfer, Thin film, Membrane, Photovoltaic system
Papers published on a yearly basis
Papers
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TL;DR: Recent advances in research into anticancer activity of BetA are discussed, including relevant modes of delivery, and the agent's therapeutic efficacy, mechanism of action, and future perspective as a pipeline anticancer drug.
Abstract: An important method of drug discovery is examination of diverse life forms, including medicinal plants and natural products or bioactive compounds isolated from these sources. In cancer research, lead structures of compounds from natural sources can be used to design novel chemotherapies with enhanced biological properties. Betulinic acid (3β-hydroxy-lup-20(29)-en-28-oic acid or BetA) is a naturally occurring pentacyclic triterpene with a wide variety of biological activities, including potent antitumor properties. Non-malignant cells and normal tissues are not affected by BetA. Because BetA exerts its effects directly on the mitochondrion and triggers death of cancerous cells, it is an important alternative when certain chemotherapy drugs fail. Mitochondrion-targeted agents such as BetA hold great promise to circumvent drug resistance in human cancers. BetA is being developed by a large network of clinical trial groups with the support of the U.S. National Cancer Institute. This article discusses recent advances in research into anticancer activity of BetA, relevant modes of delivery, and the agent's therapeutic efficacy, mechanism of action, and future perspective as a pipeline anticancer drug. BetA is a potentially important agent in cancer therapeutics.
117 citations
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TL;DR: This review paper provides a thorough discussion on the challenges and opportunities regarding the further utilization and application of biocoagulants/bioflocculants in water and wastewater treatment, including the importance of the selection of raw materials, the simplification of extraction processes, the application to different water and Wastewater characteristics, and the scaling up of this technology to a real industrial scale.
Abstract: The utilization of metal-based conventional coagulants/flocculants to remove suspended solids from drinking water and wastewater is currently leading to new concerns. Alarming issues related to the prolonged effects on human health and further pollution to aquatic environments from the generated nonbiodegradable sludge are becoming trending topics. The utilization of biocoagulants/bioflocculants does not produce chemical residue in the effluent and creates nonharmful, biodegradable sludge. The conventional coagulation-flocculation processes in drinking water and wastewater treatment, including the health and environmental issues related to the utilization of metal-based coagulants/flocculants during the processes, are discussed in this paper. As a counterpoint, the development of biocoagulants/bioflocculants for drinking water and wastewater treatment is intensively reviewed. The characterization, origin, potential sources, and application of this green technology are critically reviewed. This review paper also provides a thorough discussion on the challenges and opportunities regarding the further utilization and application of biocoagulants/bioflocculants in water and wastewater treatment, including the importance of the selection of raw materials, the simplification of extraction processes, the application to different water and wastewater characteristics, the scaling up of this technology to a real industrial scale, and also the potential for sludge recovery by utilizing biocoagulants/bioflocculants in water/wastewater treatment.
117 citations
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TL;DR: Curcumin is a potential candidate for the treatment of osteoarthritis and more well-planned randomized control trials and enhanced curcumin formulation are required to justify the use of curcuming in treating osteoartritis.
Abstract: Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide. It has an underlying inflammatory cause, which contributes to the loss of chondrocytes, leading to diminished cartilage layer at the affected joints. Compounds with anti-inflammatory properties are potential treatment agents for osteoarthritis. Curcumin derived from Curcuma species is an anti-inflammatory compound as such. This review aims to summarize the antiosteoarthritic effects of curcumin derived from clinical and preclinical studies. Many clinical trials have been conducted to determine the effectiveness of curcumin in osteoarthritic patients. Extracts of Curcuma species, curcuminoids and enhanced curcumin, were used in these studies. Patients with osteoarthritis showed improvement in pain, physical function, and quality of life after taking curcumin. They also reported reduced concomitant usage of analgesics and side effects during treatment. In vitro studies demonstrated that curcumin could prevent the apoptosis of chondrocytes, suppress the release of proteoglycans and metal metalloproteases and expression of cyclooxygenase, prostaglandin E-2, and inflammatory cytokines in chondrocytes. These were achieved by blocking the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) system in the chondrocytes, by preventing the activation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, phosphorylation, and translocation of the p65 subunit of NF-κB complexes into the nucleus. In conclusion, curcumin is a potential candidate for the treatment of osteoarthritis. More well-planned randomized control trials and enhanced curcumin formulation are required to justify the use of curcumin in treating osteoarthritis.
117 citations
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TL;DR: In this paper, a new approach was proposed to determine factors influencing organic food consumption by focusing on those who are consuming and not those considering purchasing organic food, and the results indicated that product-specific attitude (PSA), sensory appeal (SA) and health orientation (HO) had a significant positive influence on individuals consumption of organic food.
117 citations
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TL;DR: In this paper, a review of the existing literature of the various fouling indices associated with a number of selected physicochemical factors is presented, including surface porosity, membrane material, membrane hydrophobicity, membrane molecular cut-off, pore size, feedwater composition, and hydrodynamic conditions (i.e., crossflow velocity, permeate flux and temperature).
117 citations
Authors
Showing all 26827 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jonathan E. Shaw | 114 | 629 | 108114 |
Sabu Thomas | 102 | 1554 | 51366 |
Biswajeet Pradhan | 98 | 735 | 32900 |
Haji Hassan Masjuki | 97 | 502 | 29653 |
Mika Sillanpää | 96 | 1019 | 44260 |
Choon Nam Ong | 86 | 444 | 25157 |
Keith R. Abrams | 86 | 355 | 30980 |
Kamaruzzaman Sopian | 84 | 989 | 25293 |
Benedikt M. Kessler | 82 | 385 | 24243 |
Michel Marre | 82 | 444 | 39052 |
Peter Willett | 76 | 479 | 29037 |
Peter F. M. Choong | 72 | 532 | 18185 |
Nidal Hilal | 72 | 395 | 21524 |
Margareta Nordin | 72 | 267 | 19578 |
Teuku Meurah Indra Mahlia | 70 | 339 | 17444 |