Institution
National University of Malaysia
Education•Kuala Lumpur, Malaysia•
About: National University of Malaysia is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Heat transfer. The organization has 26593 authors who have published 41270 publications receiving 552683 citations. The organization is also known as: NUM & Universiti Kebangsaan Malaysia.
Topics: Population, Heat transfer, Thin film, Membrane, Photovoltaic system
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the performance characteristics of polymer-modified asphalt mixture (PMA) with the addition of nano-silica particles were investigated. And the results showed that 4% nano silica with PMA appears to have the greatest potential for beneficial modification of the asphalt binder.
203 citations
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TL;DR: The strong inhibition of the extracts on the phagocytic activity of neutrophils was due to the presence of their major constituents especially geraniin, corilagin, phyllanthin and hypophllanthin which were able to modulate the innate response of phagocytes at different steps.
Abstract: Recently, we have highlighted the immunomodulatory activity of the standardized extracts of Phyllanthus amarus and P. urinaria. The present study was carried out to correlate between the prevalent constituents of the herbs and their inhibitory effects on phagocytic activity of human neutrophils. The compounds, gallic acid, ellagic acid, corilagin, geraniin, phyllanthin and hypophyllanthin were identified and quantitatively analyzed in the extracts of Phyllanthus amarus and P. urinaria obtained from Malaysia and Indonesia by using a validated reversed phase high performance liquid chromatography (RP-HPLC) method. The standardized extracts and the pure compounds were evaluated for their effects on chemotaxis, β2 integrin (CD18) expression, phagocytosis and chemiluminescence of human phagocytes. Chemotactic activity was assessed using the Boyden chamber technique, inhibition of CD18 expression and phagocytic ability were tested with the aid of flow cytometry, while effect on the respiratory burst was investigated using a luminol-based chemiluminescence assay. All plant extracts strongly inhibited migration of the phagocytes with the Malaysian P. amarus depicting the highest inhibitory activity. Amongst the compounds tested, geraniin demonstrated the strongest inhibitory activity on chemotaxis of polymorphonuclear leukocytes (PMNs) and monocytes with IC50 values of 1.09 and 1.69 μM, respectively, which were lower than that of ibuprofen. All plant extracts and pure compounds exhibited high inhibitory activity on the oxidative burst of zymosan and PMA stimulated leukocytes. Geraniin and corilagin exhibited exceptionally strong inhibition on the reactive oxygen species (ROS) activity with IC50 values lower than aspirin. The plant extracts exhibited moderate inhibition of E. coli uptake by monocytes but weak effect on PMNs. Of all the compounds, phyllanthin at 50 μg/mL exhibited the highest engulfment inhibitory activity with percentage of phagocytizing cells of 14.2 and 27.1% for PMNs and monocytes, respectively. All plants and compounds tested possessed weak effect on CD18 expression on leukocytes except for hypophyllanthin and phyllanthin which exhibited significant inhibitory effect. The strong inhibition of the extracts on the phagocytic activity of neutrophils was due to the presence of their major constituents especially geraniin, corilagin, phyllanthin and hypophllanthin which were able to modulate the innate response of phagocytes at different steps.
202 citations
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TL;DR: Kinetic data were found to fit pseudo-second- order model equation as compared to pseudo-first-order model equation and the adsorption of MB onto the CA-treated kenaf core fibres was spontaneous and endothermic.
201 citations
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TL;DR: In this article, the results show that the best fit was achieved with the Sips isotherm equation with a maximum adsorption capacity of 398.19 µmg/g.
201 citations
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TL;DR: In this article, the steady two-dimensional boundary layer flow past a static or a moving wedge immersed in nanofluids is investigated numerically using an implicit finite difference scheme known as the Keller-box method and the NAG routine DO2HAF.
200 citations
Authors
Showing all 26827 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jonathan E. Shaw | 114 | 629 | 108114 |
Sabu Thomas | 102 | 1554 | 51366 |
Biswajeet Pradhan | 98 | 735 | 32900 |
Haji Hassan Masjuki | 97 | 502 | 29653 |
Mika Sillanpää | 96 | 1019 | 44260 |
Choon Nam Ong | 86 | 444 | 25157 |
Keith R. Abrams | 86 | 355 | 30980 |
Kamaruzzaman Sopian | 84 | 989 | 25293 |
Benedikt M. Kessler | 82 | 385 | 24243 |
Michel Marre | 82 | 444 | 39052 |
Peter Willett | 76 | 479 | 29037 |
Peter F. M. Choong | 72 | 532 | 18185 |
Nidal Hilal | 72 | 395 | 21524 |
Margareta Nordin | 72 | 267 | 19578 |
Teuku Meurah Indra Mahlia | 70 | 339 | 17444 |