scispace - formally typeset
Search or ask a question
Institution

New York University

EducationNew York, New York, United States
About: New York University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 72380 authors who have published 165545 publications receiving 8334030 citations. The organization is also known as: NYU & University of the City of New York.


Papers
More filters
Journal ArticleDOI
TL;DR: A survey of 317 clerical workers demonstrated that employees differed in what they defined as in-role and extra-role behavior, that these differences were related to commitment and social cues.
Abstract: A survey of 317 clerical workers demonstrated that employees differed in what they defined as in-role and extra-role behavior, that these differences were related to commitment and social cues, and...

1,209 citations

Journal ArticleDOI
TL;DR: In this paper, a cohort of 221 children with high-risk B-cell-progenitor ALL with the use of single-nucleotide-polymorphism microarrays, transcriptional profiling, and resequencing of samples obtained at diagnosis were studied.
Abstract: Background Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined. Methods We studied a cohort of 221 children with high-risk B-cell–progenitor ALL with the use of single-nucleotide–polymorphism microarrays, transcriptional profiling, and resequencing of samples obtained at diagnosis. Children with known very-high-risk ALL subtypes (i.e., BCR-ABL1–positive ALL, hypodiploid ALL, and ALL in infants) were excluded from this cohort. A copy-number abnormality was identified as a predictor of poor outcome, and it was then tested in an independent validation cohort of 258 patients with B-cell–progenitor ALL. Results More than 50 recurring copy-number abnormalities were identified, most commonly involving genes that encode regulators of B-cell development (in 66.8% of patients...

1,209 citations

Journal ArticleDOI
TL;DR: It is established that myofibroblast contraction functions as a mechanism to directly activate TGF-β1 from self-generated stores in the extracellular matrix (ECM), restricting autocrine generation of my ofibroblasts to a stiffened ECM.
Abstract: The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts and conditions that permit tension modulation on the extracellular matrix (ECM), we establish that myofibroblast contraction functions as a mechanism to directly activate TGF-beta1 from self-generated stores in the ECM. Contraction of myofibroblasts and myofibroblast cytoskeletons prepared with Triton X-100 releases active TGF-beta1 from the ECM. This process is inhibited either by antagonizing integrins or reducing ECM compliance and is independent from protease activity. Stretching myofibroblast-derived ECM in the presence of mechanically apposing stress fibers immediately activates latent TGF-beta1. In myofibroblast-populated wounds, activation of the downstream targets of TGF-beta1 signaling Smad2/3 is higher in stressed compared to relaxed tissues despite similar levels of total TGF-beta1 and its receptor. We propose activation of TGF-beta1 via integrin-mediated myofibroblast contraction as a potential checkpoint in the progression of fibrosis, restricting autocrine generation of myofibroblasts to a stiffened ECM.

1,209 citations

Journal ArticleDOI
12 Dec 2003-Science
TL;DR: Localization of expression of more than 22,000 genes in the Arabidopsis root correlates groups of genes to specific cell fates and should serve to guide reverse genetics.
Abstract: A global map of gene expression within an organ can identify genes with coordinated expression in localized domains, thereby relating gene activity to cell fate and tissue specialization. Here, we present localization of expression of more than 22,000 genes in the Arabidopsis root. Gene expression was mapped to 15 different zones of the root that correspond to cell types and tissues at progressive developmental stages. Patterns of gene expression traverse traditional anatomical boundaries and show cassettes of hormonal response. Chromosomal clustering defined some coregulated genes. This expression map correlates groups of genes to specific cell fates and should serve to guide reverse genetics.

1,206 citations

Journal ArticleDOI
TL;DR: Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of other therapeutic measures to select the most appropriate intervention.
Abstract: The healing process in acute wounds has been extensively studied and the knowledge derived from these studies has often been extrapolated to the care of chronic wounds, on the assumption that nonhealing chronic wounds were simply aberrations of the normal tissue repair process. However, this approach is less than satisfactory, as the chronic wound healing process differs in many important respects from that seen in acute wounds. In chronic wounds, the orderly sequence of events seen in acute wounds becomes disrupted or “stuck” at one or more of the different stages of wound healing. For the normal repair process to resume, the barrier to healing must be identified and removed through application of the correct techniques. It is important, therefore, to understand the molecular events that are involved in the wound healing process in order to select the most appropriate intervention. Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of other therapeutic measures. Experts in wound management consider that wound bed preparation is an important concept with significant potential as an educational tool in wound management. This article was developed after a meeting of wound healing experts in June 2002 and is intended to provide an overview of the current status, role, and key elements of wound bed preparation. Readers will be able to examine the following issues; • the current status of wound bed preparation; • an analysis of the acute and chronic wound environments; • how wound healing can take place in these environments; • the role of wound bed preparation in the clinic; • the clinical and cellular components of the wound bed preparation concept; • a detailed analysis of the components of wound bed preparation. (WOUND REP REG 2003;11:1–28)

1,206 citations


Authors

Showing all 73237 results

NameH-indexPapersCitations
Rob Knight2011061253207
Virginia M.-Y. Lee194993148820
Frank E. Speizer193636135891
Stephen V. Faraone1881427140298
Eric R. Kandel184603113560
Andrei Shleifer171514271880
Eliezer Masliah170982127818
Roderick T. Bronson169679107702
Timothy A. Springer167669122421
Alvaro Pascual-Leone16596998251
Nora D. Volkow165958107463
Dennis R. Burton16468390959
Charles N. Serhan15872884810
Giacomo Bruno1581687124368
Tomas Hökfelt158103395979
Network Information
Related Institutions (5)
University of Pennsylvania
257.6K papers, 14.1M citations

98% related

Columbia University
224K papers, 12.8M citations

98% related

Yale University
220.6K papers, 12.8M citations

97% related

Harvard University
530.3K papers, 38.1M citations

97% related

University of Washington
305.5K papers, 17.7M citations

96% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023245
20221,205
20218,761
20209,108
20198,417
20187,680