Institution
New York University
Education•New York, New York, United States•
About: New York University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 72380 authors who have published 165545 publications receiving 8334030 citations. The organization is also known as: NYU & University of the City of New York.
Topics: Population, Poison control, Context (language use), Health care, Cancer
Papers published on a yearly basis
Papers
More filters
TL;DR: The results indicate that circulating activated platelets and platelet–leukocyte/monocyte aggregates promote formation of atherosclerotic lesions.
Abstract: We studied whether circulating activated platelets and platelet-leukocyte aggregates cause the development of atherosclerotic lesions in apolipoprotein-E-deficient (Apoe(-/-)) mice. Circulating activated platelets bound to leukocytes, preferentially monocytes, to form platelet-monocyte/leukocyte aggregates. Activated platelets and platelet-leukocyte aggregates interacted with atherosclerotic lesions. The interactions of activated platelets with monocytes and atherosclerotic arteries led to delivery of the platelet-derived chemokines CCL5 (regulated on activation, normal T cell expressed and secreted, RANTES) and CXCL4 (platelet factor 4) to the monocyte surface and endothelium of atherosclerotic arteries. The presence of activated platelets promoted leukocyte binding of vascular cell adhesion molecule-1 (VCAM-1) and increased their adhesiveness to inflamed or atherosclerotic endothelium. Injection of activated wild-type, but not P-selectin-deficient, platelets increased monocyte arrest on the surface of atherosclerotic lesions and the size of atherosclerotic lesions in Apoe(-/-) mice. Our results indicate that circulating activated platelets and platelet-leukocyte/monocyte aggregates promote formation of atherosclerotic lesions. This role of activated platelets in atherosclerosis is attributed to platelet P-selectin-mediated delivery of platelet-derived proinflammatory factors to monocytes/leukocytes and the vessel wall.
980 citations
TL;DR: New metabolic checkpoints for T cell activity are uncovered and it is demonstrated that metabolic reprogramming of tumor-reactive T cells can enhance anti-tumor T cell responses, illuminating new forms of immunotherapy.
980 citations
TL;DR: In this article, a simplified cognitive model is proposed to assess the dynamic aspect of consumer satisfaction/dissatisfaction in consecutive purchase behavior, which is found to have a significant role in consumer satisfaction.
Abstract: A simplified cognitive model is proposed to assess the dynamic aspect of consumer satisfaction/dissatisfaction in consecutive purchase behavior. Satisfaction is found to have a significant role in ...
979 citations
TL;DR: The authors found that corporate risk-taking and firm growth rates are positively related to the quality of investor protection, and that in better investor protection environments, stakeholders like creditors, labor groups, and the government are less effective in reducing corporate risk taking for their self-interest.
Abstract: Better investor protection could lead corporations to undertake riskier but value-enhancing investments. For example, better investor protection mitigates the taking of private benefits leading to excess risk-avoidance. Further, in better investor protection environments, stakeholders like creditors, labor groups, and the government are less effective in reducing corporate risk-taking for their self-interest. However, arguments can also be made for a negative relationship between investor protection and risk-taking. Using a cross-country panel and a U.S.-only sample, we find that corporate risk-taking and firm growth rates are positively related to the quality of investor protection.
979 citations
Yale University1, Stanford University2, University of Toronto3, Harvard University4, University of California, Santa Cruz5, University of North Carolina at Chapel Hill6, Ontario Institute for Cancer Research7, New York University8, Stony Brook University9, University of Cambridge10, Hoffmann-La Roche11, Lawrence Berkeley National Laboratory12, University of California, San Diego13, Rockefeller University14, University of Washington15, National Institutes of Health16, University of Michigan17, Fred Hutchinson Cancer Research Center18, Max Planck Society19, Memorial Sloan Kettering Cancer Center20, Weizmann Institute of Science21, Max Delbrück Center for Molecular Medicine22, Cold Spring Harbor Laboratory23, Vanderbilt University24, New York University Abu Dhabi25
TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.
Abstract: We systematically generated large-scale data sets to improve genome annotation for the nematode Caenorhabditis elegans, a key model organism. These data sets include transcriptome profiling across a developmental time course, genome-wide identification of transcription factor-binding sites, and maps of chromatin organization. From this, we created more complete and accurate gene models, including alternative splice forms and candidate noncoding RNAs. We constructed hierarchical networks of transcription factor-binding and microRNA interactions and discovered chromosomal locations bound by an unusually large number of transcription factors. Different patterns of chromatin composition and histone modification were revealed between chromosome arms and centers, with similarly prominent differences between autosomes and the X chromosome. Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome.
978 citations
Authors
Showing all 73237 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Rob Knight | 201 | 1061 | 253207 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Eric R. Kandel | 184 | 603 | 113560 |
| Andrei Shleifer | 171 | 514 | 271880 |
| Eliezer Masliah | 170 | 982 | 127818 |
| Roderick T. Bronson | 169 | 679 | 107702 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Alvaro Pascual-Leone | 165 | 969 | 98251 |
| Nora D. Volkow | 165 | 958 | 107463 |
| Dennis R. Burton | 164 | 683 | 90959 |
| Charles N. Serhan | 158 | 728 | 84810 |
| Giacomo Bruno | 158 | 1687 | 124368 |
| Tomas Hökfelt | 158 | 1033 | 95979 |