New York University

About: New York University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 72380 authors who have published 165545 publications receiving 8334030 citations. The organization is also known as: NYU & University of the City of New York.

An empirical study of the impact of user involvement on system usage and information satisfaction

Abstract: "User involvement" in information system development is generally considered an important mechanism for improving system quality and ensuring successful system implementation. The common assumption that user involvement leads to system usage and/or information satisfaction is examined in a survey of 200 production managers. Alternative models exploring the causal ordering of the three variables are developed and tested via path analysis. The results demonstrate that user involvement in the development of information systems will enhance both system usage and the user's satisfaction with the system. Further, the study provides evidence that the user's satisfaction with the system will lead to greater system usage.

The first data release of the sloan digital sky survey

Abstract: The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its First Data Release. This consists of 2099 deg2 of five-band (u, g, r, i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating blank sky patches selected over 1360 deg2 of this area, and tables of measured parameters from these data. The imaging data go to a depth of r ≈ 22.6 and are photometrically and astrometrically calibrated to 2% rms and 100 mas rms per coordinate, respectively. The spectra cover the range 3800–9200 A, with a resolution of 1800–2100. This paper describes the characteristics of the data with emphasis on improvements since the release of commissioning data (the SDSS Early Data Release) and serves as a pointer to extensive published and on-line documentation of the survey.

Does Option Compensation Increase Managerial Risk Appetite

Abstract: This paper solves the dynamic investment problem of a risk averse manager compensated with a call option on the assets he controls. Under the manager’s optimal policy, the option ends up either deep in or deep out of the money. As the asset value goes to zero, volatility goes to infinity. However, the option compensation does not strictly lead to greater risk seeking. Sometimes, the manager’s optimal volatility is less with the option than it would be if he were trading his own account. Furthermore, giving the manager more options causes him to reduce volatility. MANAGERS WITH CONVEX COMPENSATION SCHEMES play an important role in financial markets. This paper solves for the optimal dynamic investment policy for a risk averse manager paid with a call option on the assets he controls. The paper focuses on how the option compensation impacts the manager’s appetite for risk when he cannot hedge the option position. On one hand, the convexity of the option makes the manager shun payoffs that are likely to be near the money. Under the optimal policy, the manager either significantly outperforms his benchmark or else incurs severe losses. Furthermore, in examples of optimal trading strategies, asset volatility goes to infinity as asset value goes to zero. Yet option compensation does not strictly lead to greater risk seeking. As asset value grows large, or if the evaluation date is far away, the manager moderates asset risk. For example, if the manager has constant relative risk aversion ~CRRA!, asset volatility converges to the Merton constant as asset value goes to infinity. In some situations, the manager actually chooses a lower asset volatility than he would if he were investing on his own, because the leverage inherent in his option magnifies his exposure to the asset volatility. In addition, with all constant or decreasing absolute risk averse utility functions from the hyperbolic absolute risk averse ~HARA! class, giving the manager more options causes him to reduce asset volatility. In the CRRA case, for example, the manager targets a fixed volatility for his personal

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Abstract: Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Abstract: HOW do distinct protein-tyrosine kinases activate specific downstream events? Src-homology-2 (SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize phosphotyrosine in a specific sequence context and thereby provide some specificity1–3. The role of the catalytic site of tyrosine kinases in determining target specificity has not been fully investigated. Here we use a degenerate peptide library to show that each of nine tyrosine kinases investigated has a unique optimal peptide substrate. We find that the cytosolic tyrosine kinases preferentially phosphorylate peptides recognized by their own SH2 domains or closely related SH2 domains (group I; ref. 3), whereas receptor tyrosine kinases preferentially phosphorylate peptides recognized by subsets of group III SH2 domains3. The importance of these findings for human disease is underscored by our observation that a point mutation in the RET receptor-type tyrosine kinase, which causes multiple endocrine neoplasia type 2B, results in a shift in peptide substrate specificity.