Institution
North Carolina State University
Education•Raleigh, North Carolina, United States•
About: North Carolina State University is a education organization based out in Raleigh, North Carolina, United States. It is known for research contribution in the topics: Population & Thin film. The organization has 44161 authors who have published 101744 publications receiving 3456774 citations. The organization is also known as: NCSU & North Carolina State University at Raleigh.
Topics: Population, Thin film, Gene, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: An approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR–cas loci into distinct classes, types and subtypes is presented.
Abstract: The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR-cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR-Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized.
1,988 citations
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TL;DR: A generalized framework of network quality functions was developed that allowed us to study the community structure of arbitrary multislice networks, which are combinations of individual networks coupled through links that connect each node in one network slice to itself in other slices.
Abstract: Network science is an interdisciplinary endeavor, with methods and applications drawn from across the natural, social, and information sciences. A prominent problem in network science is the algorithmic detection of tightly connected groups of nodes known as communities. We developed a generalized framework of network quality functions that allowed us to study the community structure of arbitrary multislice networks, which are combinations of individual networks coupled through links that connect each node in one network slice to itself in other slices. This framework allows studies of community structure in a general setting encompassing networks that evolve over time, have multiple types of links (multiplexity), and have multiple scales.
1,982 citations
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TL;DR: It is argued that the improvements in reusability, reproducibility and comprehensiveness are sufficiently great that ASVs should replace OTUs as the standard unit of marker-gene analysis and reporting.
Abstract: Recent advances have made it possible to analyze high-throughput marker-gene sequencing data without resorting to the customary construction of molecular operational taxonomic units (OTUs): clusters of sequencing reads that differ by less than a fixed dissimilarity threshold. New methods control errors sufficiently such that amplicon sequence variants (ASVs) can be resolved exactly, down to the level of single-nucleotide differences over the sequenced gene region. The benefits of finer resolution are immediately apparent, and arguments for ASV methods have focused on their improved resolution. Less obvious, but we believe more important, are the broad benefits that derive from the status of ASVs as consistent labels with intrinsic biological meaning identified independently from a reference database. Here we discuss how these features grant ASVs the combined advantages of closed-reference OTUs—including computational costs that scale linearly with study size, simple merging between independently processed data sets, and forward prediction—and of de novo OTUs—including accurate measurement of diversity and applicability to communities lacking deep coverage in reference databases. We argue that the improvements in reusability, reproducibility and comprehensiveness are sufficiently great that ASVs should replace OTUs as the standard unit of marker-gene analysis and reporting.
1,977 citations
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TL;DR: A comprehensive review of polymer nanocomposite research can be found in this paper, including fundamental structure/property relationships, manufacturing techniques, and applications of polymer nano-composite materials.
Abstract: This review is designed to be a comprehensive source for polymer nanocomposite research, including fundamental structure/property relationships, manufacturing techniques, and applications of polymer nanocomposite materials. In addition to presenting the scientific framework for the advances in polymer nanocomposite research, this review focuses on the scientific principles and mechanisms in relation to the methods of processing and manufacturing with a discussion on commercial applications and health/safety concerns (a critical issue for production and scale-up). Hence, this review offers a comprehensive discussion on technology, modeling, characterization, processing, manufacturing, applications, and health/safety concerns for polymer nanocomposites.
1,976 citations
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California Institute of Technology1, University of California, Berkeley2, Lawrence Livermore National Laboratory3, Technical University of Denmark4, Columbia University5, Goddard Space Flight Center6, INAF7, SLAC National Accelerator Laboratory8, McGill University9, University of Toulouse10, Hoffmann-La Roche11, Inter-University Centre for Astronomy and Astrophysics12, Durham University13, Sonoma State University14, Roma Tre University15, Santa Cruz Institute for Particle Physics16, Georgia Institute of Technology17, Pontifical Catholic University of Chile18, Pennsylvania State University19, Harvard University20, Massachusetts Institute of Technology21, University of Cambridge22, Virginia Tech23, Los Alamos National Laboratory24, Quest University25, University of Michigan26, Weizmann Institute of Science27, North Carolina State University28, Willamette University29, University of Concepción30, Yale University31
TL;DR: The Nuclear Spectroscopic Telescope Array (NuSTAR) as discussed by the authors is the first focusing high-energy X-ray telescope in orbit, which operates in the band from 3 to 79 keV.
Abstract: The Nuclear Spectroscopic Telescope Array (NuSTAR) mission, launched on 2012 June 13, is the first focusing high-energy X-ray telescope in orbit. NuSTAR operates in the band from 3 to 79 keV, extending the sensitivity of focusing far beyond the ~10 keV high-energy cutoff achieved by all previous X-ray satellites. The inherently low background associated with concentrating the X-ray light enables NuSTAR to probe the hard X-ray sky with a more than 100-fold improvement in sensitivity over the collimated or coded mask instruments that have operated in this bandpass. Using its unprecedented combination of sensitivity and spatial and spectral resolution, NuSTAR will pursue five primary scientific objectives: (1) probe obscured active galactic nucleus (AGN) activity out to the peak epoch of galaxy assembly in the universe (at z ≾ 2) by surveying selected regions of the sky; (2) study the population of hard X-ray-emitting compact objects in the Galaxy by mapping the central regions of the Milky Way; (3) study the non-thermal radiation in young supernova remnants, both the hard X-ray continuum and the emission from the radioactive element ^(44)Ti; (4) observe blazars contemporaneously with ground-based radio, optical, and TeV telescopes, as well as with Fermi and Swift, to constrain the structure of AGN jets; and (5) observe line and continuum emission from core-collapse supernovae in the Local Group, and from nearby Type Ia events, to constrain explosion models. During its baseline two-year mission, NuSTAR will also undertake a broad program of targeted observations. The observatory consists of two co-aligned grazing-incidence X-ray telescopes pointed at celestial targets by a three-axis stabilized spacecraft. Deployed into a 600 km, near-circular, 6° inclination orbit, the observatory has now completed commissioning, and is performing consistent with pre-launch expectations. NuSTAR is now executing its primary science mission, and with an expected orbit lifetime of 10 yr, we anticipate proposing a guest investigator program, to begin in late 2014.
1,966 citations
Authors
Showing all 44525 results
Name | H-index | Papers | Citations |
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Yi Cui | 220 | 1015 | 199725 |
Jing Wang | 184 | 4046 | 202769 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Carlos Bustamante | 161 | 770 | 106053 |
David W. Johnson | 160 | 2714 | 140778 |
Joseph Wang | 158 | 1282 | 98799 |
David Tilman | 158 | 340 | 149473 |
Jay Hauser | 155 | 2145 | 132683 |
James M. Tour | 143 | 859 | 91364 |
Joseph T. Hupp | 141 | 731 | 82647 |
Bin Liu | 138 | 2181 | 87085 |
Rudolph E. Tanzi | 135 | 638 | 85376 |
Richard C. Boucher | 129 | 490 | 54509 |
David B. Allison | 129 | 836 | 69697 |
Robert W. Heath | 128 | 1049 | 73171 |