Institution
North Carolina State University
Education•Raleigh, North Carolina, United States•
About: North Carolina State University is a education organization based out in Raleigh, North Carolina, United States. It is known for research contribution in the topics: Population & Thin film. The organization has 44161 authors who have published 101744 publications receiving 3456774 citations. The organization is also known as: NCSU & North Carolina State University at Raleigh.
Topics: Population, Thin film, Silicon, Gene, Poison control
Papers published on a yearly basis
Papers
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TL;DR: This study reviews the recent development in boronic acid compounds during the last six years and outlines the priorities for further research into these compounds.
Abstract: Boronic acid compounds have been used, because of their unique structural features, for the development of potent enzyme inhibitors, boron neutron capture agents for cancer therapy, and as antibody mimics that recognize biologically important saccharides. Consequently, there has been a surge of interests in boronic acid compounds. This study reviews the recent development in this area during the last six years.
435 citations
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Agricultural Research Service1, University of California, Davis2, Pennsylvania State University3, North Carolina State University4, University of Georgia5, Wageningen University and Research Centre6, Broad Institute7, Centre national de la recherche scientifique8, Seoul National University9, Spanish National Research Council10, University of Warwick11, University of Western Ontario12, Agriculture and Agri-Food Canada13, University of Massachusetts Amherst14
TL;DR: Insight is revealed into the genetic mechanisms of niche adaptation of fungal wilt pathogens, advances the understanding of the evolution and development of their pathogenesis, and sheds light on potential avenues for the development of novel disease management strategies to combat destructive wilt diseases.
Abstract: The vascular wilt fungi Verticillium dahliae and V. albo-atrum infect over 200 plant species, causing billions of dollars in annual crop losses. The characteristic wilt symptoms are a result of colonization and proliferation of the pathogens in the xylem vessels, which undergo fluctuations in osmolarity. To gain insights into the mechanisms that confer the organisms' pathogenicity and enable them to proliferate in the unique ecological niche of the plant vascular system, we sequenced the genomes of V. dahliae and V. albo-atrum and compared them to each other, and to the genome of Fusarium oxysporum, another fungal wilt pathogen. Our analyses identified a set of proteins that are shared among all three wilt pathogens, and present in few other fungal species. One of these is a homolog of a bacterial glucosyltransferase that synthesizes virulence-related osmoregulated periplasmic glucans in bacteria. Pathogenicity tests of the corresponding V. dahliae glucosyltransferase gene deletion mutants indicate that the gene is required for full virulence in the Australian tobacco species Nicotiana benthamiana. Compared to other fungi, the two sequenced Verticillium genomes encode more pectin-degrading enzymes and other carbohydrate-active enzymes, suggesting an extraordinary capacity to degrade plant pectin barricades. The high level of synteny between the two Verticillium assemblies highlighted four flexible genomic islands in V. dahliae that are enriched for transposable elements, and contain duplicated genes and genes that are important in signaling/transcriptional regulation and iron/lipid metabolism. Coupled with an enhanced capacity to degrade plant materials, these genomic islands may contribute to the expanded genetic diversity and virulence of V. dahliae, the primary causal agent of Verticillium wilts. Significantly, our study reveals insights into the genetic mechanisms of niche adaptation of fungal wilt pathogens, advances our understanding of the evolution and development of their pathogenesis, and sheds light on potential avenues for the development of novel disease management strategies to combat destructive wilt diseases.
435 citations
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Virginia Commonwealth University1, University of Rochester2, Duke University3, National Institutes of Health4, University of Southern California5, United States Environmental Protection Agency6, North Carolina State University7, Harvard University8, Old Dominion University9, University of Washington10, University of California, Irvine11, University of California, Los Angeles12, University of Maryland, Baltimore13, Icahn School of Medicine at Mount Sinai14
TL;DR: Recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
Abstract: Accumulating evidence suggests that outdoor air pollution may have a significant impact on central nervous system (CNS) health and disease. To address this issue, the National Institute of Environmental Health Sciences/National Institute of Health convened a panel of research scientists that was assigned the task of identifying research gaps and priority goals essential for advancing this growing field and addressing an emerging human health concern. Here, we review recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
434 citations
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TL;DR: In this article, the onset of convection in a horizontal layer of a porous medium saturated by a nanofluid is studied analytically, and it is found that the critical thermal Rayleigh number can be reduced or increased by a substantial amount depending on whether the basic nanoparticle distribution is top-heavy or bottom-heavy, by the presence of the nanoparticles.
434 citations
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TL;DR: Focusing mainly on dilute suspensions of well-dispersed spherical nanoparticles in water or ethylene glycol, recent experimental observations, associated measurement techniques, and new theories as well as useful correlations have been reviewed.
Abstract: Nanofluids, i.e., well-dispersed (metallic) nanoparticles at low- volume fractions in liquids, may enhance the mixture’s thermal conductivity, knf, over the base-fluid values. Thus, they are potentially useful for advanced cooling of micro-systems. Focusing mainly on dilute suspensions of well-dispersed spherical nanoparticles in water or ethylene glycol, recent experimental observations, associated measurement techniques, and new theories as well as useful correlations have been reviewed. It is evident that key questions still linger concerning the best nanoparticle-and-liquid pairing and conditioning, reliable measurements of achievable knf values, and easy-to-use, physically sound computer models which fully describe the particle dynamics and heat transfer of nanofluids. At present, experimental data and measurement methods are lacking consistency. In fact, debates on whether the anomalous enhancement is real or not endure, as well as discussions on what are repeatable correlations between knf and temperature, nanoparticle size/shape, and aggregation state. Clearly, benchmark experiments are needed, using the same nanofluids subject to different measurement methods. Such outcomes would validate new, minimally intrusive techniques and verify the reproducibility of experimental results. Dynamic knf models, assuming non-interacting metallic nano-spheres, postulate an enhancement above the classical Maxwell theory and thereby provide potentially additional physical insight. Clearly, it will be necessary to consider not only one possible mechanism but combine several mechanisms and compare predictive results to new benchmark experimental data sets.
434 citations
Authors
Showing all 44525 results
Name | H-index | Papers | Citations |
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Yi Cui | 220 | 1015 | 199725 |
Jing Wang | 184 | 4046 | 202769 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Carlos Bustamante | 161 | 770 | 106053 |
David W. Johnson | 160 | 2714 | 140778 |
Joseph Wang | 158 | 1282 | 98799 |
David Tilman | 158 | 340 | 149473 |
Jay Hauser | 155 | 2145 | 132683 |
James M. Tour | 143 | 859 | 91364 |
Joseph T. Hupp | 141 | 731 | 82647 |
Bin Liu | 138 | 2181 | 87085 |
Rudolph E. Tanzi | 135 | 638 | 85376 |
Richard C. Boucher | 129 | 490 | 54509 |
David B. Allison | 129 | 836 | 69697 |
Robert W. Heath | 128 | 1049 | 73171 |