North Carolina State University

About: North Carolina State University is a education organization based out in Raleigh, North Carolina, United States. It is known for research contribution in the topics: Population & Thin film. The organization has 44161 authors who have published 101744 publications receiving 3456774 citations. The organization is also known as: NCSU & North Carolina State University at Raleigh.

The human transcriptome across tissues and individuals

Abstract: Transcriptional regulation and posttranscriptional processing underlie many cellular and organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue Expression (GTEx) project to investigate the patterns of transcriptome variation across individuals and tissues. Tissues exhibit characteristic transcriptional signatures that show stability in postmortem samples. These signatures are dominated by a relatively small number of genes—which is most clearly seen in blood—though few are exclusive to a particular tissue and vary more across tissues than individuals. Genes exhibiting high interindividual expression variation include disease candidates associated with sex, ethnicity, and age. Primary transcription is the major driver of cellular specificity, with splicing playing mostly a complementary role; except for the brain, which exhibits a more divergent splicing program. Variation in splicing, despite its stochasticity, may play in contrast a comparatively greater role in defining individual phenotypes.

Intrusion detection in wireless ad-hoc networks

Abstract: As the recent denial-of-service attacks on several major Internet sites have shown us, no open computer network is immune from intrusions. The wireless ad-hoc network is particularly vulnerable due to its features of open medium, dynamic changing topology, cooperative algorithms, lack of centralized monitoring and management point, and lack of a clear line of defense. Many of the intrusion detection techniques developed on a fixed wired network are not applicable in this new environment. How to do it differently and effectively is a challenging research problem. In this paper, we first examine the vulnerabilities of a wireless ad-hoc network, the reason why we need intrusion detection, and the reason why the current methods cannot be applied directly. We then describe the new intrusion detection and response mechanisms that we are developing for wireless ad-hoc networks.

Diffraction enhanced x-ray imaging

Abstract: Diffraction enhanced imaging is a new x-ray radiographic imaging modality using monochromatic x-rays from a synchrotron which produces images of thick absorbing objects that are almost completely free of scatter. They show dramatically improved contrast over standard imaging applied to the same phantom. The contrast is based not only on attenuation but also the refraction and diffraction properties of the sample. This imaging method may improve image quality for medical applications, industrial radiography for non-destructive testing and x-ray computed tomography.

An Introduction to the Policy Process : Theories, Concepts and Models of Public Policy Making

Abstract: A concise, accessible introduction to the public policy process that can be read on may levels. The author's direct writing style and extensive use of examples will appeal to students as well as practitioners. The book offers an extensive overview of the best current thinking on the policy process, with an emphasis on accessibility and synthesis rather than novelty or abstraction. An extensive glossary of terms, keyed to the chapters in which each term is most thoroughly discussed; an annotated bibliography; and an introduction to web-based research, with a guide to the most important and reliable public policy research sites, are among the book's many useful features.