North Eastern Hill University

About: North Eastern Hill University is a education organization based out in Shillong, Meghalaya, India. It is known for research contribution in the topics: Population & Ruthenium. The organization has 2318 authors who have published 4476 publications receiving 48894 citations.

Anthelmintic efficacy of gold nanoparticles derived from a phytopathogenic fungus, Nigrospora oryzae.

Abstract: Exploring a green chemistry approach, this study brings to the fore, the anthelmintic efficacy of gold nanoparticles, highlighting the plausible usage of myconanotechnology. Gold nanoparticles of ∼6 to ∼18 nm diameter were synthesized by treating the mycelia-free culture filtrate of the phytopathogenic fungus with gold chloride. Their size and morphology were confirmed by UV-Vis spectroscopy, DLS data, AFM and TEM images. The XRD studies reveal a crystalline nature of the nanoparticles, which are in cubic phase. The FTIR spectroscopic studies before and after the formation of nanoparticles show the presence of possible functional groups responsible for the bio-reduction and capping of the synthesized gold nanoparticles. The latter were tested as vermifugal agents against a model cestode Raillietina sp., an intestinal parasite of domestic fowl. Further, ultrastructural and biochemical parameters were used to corroborate the efficacy study.

Vitamin C mediated protection on cisplatin induced mutagenicity in mice.

Abstract: In present studies the development of chromosomal aberrations, micronuclei in bone marrow cells and sperm head abnormalities were used as mutagenic bioassay in Swiss albino mice treated with cisplatin alone or ascorbic plus cisplatin. It was noted that in the combined treated hosts the frequency of all the mutagenic parameters were always significantly less than that treated with cisplatin alone. These findings suggest a protective role of ascorbic acid against cisplatin induced mutagenic potentials. Interestingly, in combined treated hosts glutathione (GSH) level in bone marrow cells increased significantly which may suggest a possible mechanism of ascorbic acid mediated protection against cisplatin induced mutagenic potentials in the hosts.

Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase

Abstract: Amyloidogenic pathway in Alzheimer's disease (AD) involves breakdown of APP by β-secretase followed by γ-secretase and results in formation of amyloid beta plaque. β-secretase has been a promising target for developing novel anti-Alzheimer drugs. To test different molecules for this purpose, test ligands like acylguanidine 7a, rosiglitazone, pioglitazone, and tartaric acid were docked against our target protein β-secretase enzyme retrieved from Protein Data Bank, considering MK-8931 (phase III trial, Merck) as the positive control. Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to β-secretase. In silico ADMET predictions revealed that except tartaric acid all other compounds had minimal toxic effects and had good absorption as well as solubility characteristics. These compounds may serve as potential lead compound for developing new anti-Alzheimer drug.

Biodiversity Value, Status, and Strategies for Conservation of Sacred Groves of Meghalaya, India

Abstract: The tribal communities of Meghalaya in northeast India—Khasis, Garos, and Jaintias—have a tradition of environmental conservation based on various religious beliefs which have been passed on from one generation to the other. Based on these beliefs, certain patches of forests are designated as sacred groves under customary law and are protected from any product extraction by the community. Such forests are very rich in biological diversity and harbor many endangered plant species including rare herbs and medicinal plants. Seventy-nine sacred groves were located, denoted on a geographical map of Meghalaya, and studied for their biodiversity value, status, and vegetation characteristics. A baseline floristic survey revealed that at least 514 species representing 340 genera and 131 families were present in these sacred groves. The status of sacred groves was ascertained through canopy cover estimate. A little over 1.3% of total sacred grove area was undisturbed, 42.1% had relatively dense forest, 26.3% had sparse canopy cover, and 30.3% had open forest. The vegetation characteristics and species diversity of an undisturbed sacred grove were compared with that of an unprotected disturbed forest. The species diversity indices were higher for the sacred grove than for the disturbed forest. The species composition and community characteristics differed significantly between the two forests. Sociocultural aspects of sacred grove conservation were analyzed, and views of the local people were enlisted. Based on the findings, conservation strategies for sacred groves were suggested.

A new rapid method of air‐drying for scanning electron microscopy using tetramethylsilane

Abstract: SUMMARY A new rapid air-drying technique which gives results comparable to critical point-drying is described for scanning electron microscopy, using a trematode parasite, Homalogaster paloniae, as a test specimen.