Institution
North Eastern Hill University
Education•Shillong, Meghalaya, India•
About: North Eastern Hill University is a education organization based out in Shillong, Meghalaya, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 2318 authors who have published 4476 publications receiving 48894 citations.
Topics: Population, Catalysis, Ruthenium, Ligand, Aqueous solution
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors used high-throughput interface-based protein design to generate >100k designs of the favipiravir-binding site of RdRp and identify mutational hotspots.
19 citations
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TL;DR: In this article, a sample of calcium vanadate apatite, Ca10(VO4)6(OH)2 was prepared at 110°C and characterized through X-ray, electron microscopic, infrared and thermoanalytical analyses in addition to chemical analysis.
Abstract: By appropriate modifications of existing precipitation methods, a sample of calcium vanadate apatite, Ca10(VO4)6(OH)2 was prepared at 110°C. It was characterized through X-ray, electron microscopic, infrared and thermoanalytical analyses in addition to chemical analysis. Equilibrating the sample in buffered aqueous media at 37° C, the solubility was measured using microanalytical techniques of Ca2+ and VO4
3− present in the saturated solutions after separating the colloidal component of the solute. Duration of equilibration for the attainment of saturation of the solution of the sample was obtained from a study on its dissolution kinetics. The pK
ip of calcium vanadate apatite was found to be 107.09. The investigation showed that pK
ip was independent of the presence of the common ions.
19 citations
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TL;DR: 45 genes were found to be differentially methylated within the promoter region, of which 38 were hypermethylated and 7 hypomethylated, which may serve as candidate methylation biomarkers for OSCC in this poorly characterized ethnic group.
19 citations
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TL;DR: The induction of gluconeogenesis under environmental hypertonicity, which this catfish faces regularly in its natural habitat, possibly occurs as a consequence of changes in hydration status/cell volume of different cell types, and would certainly assist in maintaining glucose homeostasis.
Abstract: The present study was aimed at determining the effect of hypertonicity due to increased environmental water salinity on gluconeogenesis in air-breathing walking catfish (Clarias batrachus). In situ exposure to hypertonic saline solution (150 mM NaCl) led to a significant stimulation of glucose efflux due to gluconeogenesis from the liver after 7 days with further elevation after 14 days in the presence of each of the three potential gluconeogenic substrates (lactate, pyruvate, and glutamate). This was accompanied by significant increase of activities of three key gluconeogenic enzymes, namely phosphoenolpyruvate carboxykinase (PEPCK), fructose 1,6-biphosphatase (FBPase), and glucose 6-phosphatase (G6Pase) in liver and kidney by about twofold to threefold. Environmental hypertonicity also led to a significant elevation in the levels of PEPCK, FBPase, and G6Pase enzyme proteins in both the tissues by about 2- to 2.75-fold, accompanied by a significant elevation in the level of PEPCK mRNA by about 2- to 2.5-fold after 7 days, and further enhancement to about 3.5- to 4-fold after 14 days. Thus, the upregulation of PEPCK, FBPase. and G6Pase activities appears to be a result of transcriptional regulation of these genes. The induction of gluconeogenesis under environmental hypertonicity, which this catfish faces regularly in its natural habitat, possibly occurs as a consequence of changes in hydration status/cell volume of different cell types. This would certainly assist in maintaining glucose homeostasis, and also for a proper energy supply to support metabolic demands for ion transport and other altered metabolic processes under various environmental hypertonic stress-related insults.
19 citations
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TL;DR: Although the nature of LYS–drug interaction remains invariant, the extent of quenching interaction as well as the drug binding ability is strongly modulated in presence of NPs.
Abstract: The modulated bioactivity of proteins immobilized on nanoparticle (NP) interfaces is of tremendous interest toward designing better therapeutic and diagnostic tools. In this work, binding behavior ...
19 citations
Authors
Showing all 2368 results
Name | H-index | Papers | Citations |
---|---|---|---|
Vivek Sharma | 150 | 3030 | 136228 |
Patrick J. Carroll | 58 | 505 | 13046 |
Majeti Narasimha Vara Prasad | 56 | 227 | 15193 |
Arun Sharma | 55 | 371 | 11364 |
Michael Schmittel | 53 | 387 | 10461 |
Birgitta Bergman | 52 | 187 | 10975 |
Harikesh Bahadur Singh | 46 | 307 | 7372 |
Lal Chand Rai | 40 | 134 | 4513 |
B. Dey | 40 | 354 | 8089 |
Hiriyakkanavar Ila | 36 | 407 | 5633 |
Jürgen-Hinrich Fuhrhop | 35 | 208 | 5130 |
Sreebrata Goswami | 34 | 142 | 3228 |
Gagan B.N. Chainy | 33 | 107 | 4151 |
J.P. Gaur | 31 | 64 | 3957 |
Hiriyakkanavar Junjappa | 30 | 349 | 4102 |