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Institution

North Eastern Hill University

EducationShillong, Meghalaya, India
About: North Eastern Hill University is a education organization based out in Shillong, Meghalaya, India. It is known for research contribution in the topics: Population & Ruthenium. The organization has 2318 authors who have published 4476 publications receiving 48894 citations.
Topics: Population, Ruthenium, Ligand, Catalysis, Micelle


Papers
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Journal ArticleDOI
TL;DR: The data represented in this study suggested that the RAPD method was a valuable tool for estimation of genetic diversity and genetic relatedness of the D. nobile germplasm.
Abstract: Dendrobium nobile Lindl., is an orchid species of immense biopharmaceutical and horticultural importance. The knowledge of its existent genetic variations within wild accessions is crucial for formulation of sustainable utilization strategies. It is distributed in a large landscape area and can grow at altitudes ranging from 800 to 2,000 m. Given that Orchidaceae is one of the largest families of flowering plants, reports on their existing genetic diversity are extremely limited. Molecular study on D. nobile can provide valuable information about the genetic diversity level and genetic relatedness of this important medicinal orchid species. Knowledge of genetic structure of a species also provides resources of a species with its current feature and future evolutionary potential. The genetic structure of D. nobile from Northeast India was investigated using randomly amplified polymorphic DNA (RAPD).The PIC value of RAPD primers was 0.74 and Rp values ranged between 6.80 and 13.23. Overall the Shannon Index, Global coefficient of genetic differentiation (G ST), showed that relative genetic diversity of the populations was fairly high. However, the low value of gene flow (Nm = 0.27) was revealed by the RAPD marker. The results of analysis of molecular variance (AMOVA) revealed that variation amongst the populations was significantly higher than within the populations. A combination of UPGMA and STRUCTURE analysis was employed to estimate the genetic relationships of D. nobile germplasm; interestingly, both the methods presented similar grouping pattern with few differences. Results revealed that 60 individuals belonging to six natural populations in Northeast India were clustered into two major groups. The data represented in this study suggested that the RAPD method was a valuable tool for estimation of genetic diversity and genetic relatedness of the D. nobile germplasm. The present findings are useful outcomes for germplasm conservation and formulation of new breeding strategies for this extremely important medicinal orchid species.

32 citations

Journal ArticleDOI
TL;DR: Toxicity studies of the tributyltin(IV) complexes of the 4]-((E)-1-{2-hydroxy-5-[(E)-2-(2-carboxyphenyl)1-diazenyl]phenyl}methylidene)amino]aryls on the second larval instar of the Aedes aegypti and Anopheles stephensi mosquito larvae are also reported as discussed by the authors.
Abstract: (Bu3Sn[O2CC6H4{N N(C6H3-4-OH(C(H) NC6H4OCH3-4))}-o])n reveals a polymeric structure. Toxicity studies of the tributyltin(IV) complexes of the 4-[((E)-1-{2-hydroxy-5-[(E)-2-(2-carboxyphenyl)1-diazenyl]phenyl}methylidene)amino]aryls on the second larval instar of the Aedes aegypti and Anopheles stephensi mosquito larvae are also reported. The LC50 values indicate that the complexes are effective larvicides, which range from a low of 0.36 ppm to a high of 0.69 ppm against the Ae. aegypti larvae and between 0.82 and 1.17 ppm against the An. stephensi larvae. Copyright  2005 John Wiley & Sons, Ltd.

32 citations

Journal ArticleDOI
TL;DR: In this paper, a detailed analysis of sparticle mass spectrum in supersymmetric grand unified theories is carried out analytically by integrating the one-loop renormalization group equations with appropriate boundary conditions implied by the underlying grand unified gauge group.
Abstract: We carry out a detailed analysis of sparticle mass spectrum in supersymmetric grand unified theories. We consider the spectroscopy of the squarks and sleptons in SU(5) and SO(10) grand unified theories, and show how the underlying supersymmetry breaking parameters of these theories can be determined from a measurement of different sparticle masses. This analysis is done analytically by integrating the one-loop renormalization group equations with appropriate boundary conditions implied by the underlying grand unified gauge group. We also consider the impact of non-universal gaugino masses on the sparticle spectrum, especially the neutralino and chargino masses which arise in supersymmetric grand unified theories with non-minimal gauge kinetic function. In particular, we study the interrelationships between the squark and slepton masses which arise in grand unified theories at the one-loop level, which can be used to distinguish between the different underlying gauge groups and their breaking pattern to the Standard Model gauge group. We also comment on the corrections that can affect these one-loop results.

32 citations

Journal ArticleDOI
TL;DR: Two compounds displayed considerable structural and pharmacological properties and could be probable drug candidates to fight against M tuberculosis parasites.
Abstract: Persistent infection by Mycobacterium tuberculosis requires the glyoxylate shunt This is a bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase (MS) catalyze the net incorporation of carbon during mycobacterial growth on acetate or fatty acids as the primary carbon source To identify a potential antitubercular compound, we performed a structure-based screening of natural compounds from the ZINC database (n = 1 67 740) against the M tuberculosis MS (MtbMS) structure The ligands were screened against MtbMS, and 354 ligands were found to have better docking score These compounds were assessed for Lipinski and absorption, distribution, metabolism, excretion, and toxicity prediction where 15 compounds were found to fit well for redocking studies After refinement by molecular docking and drug-likeness analysis, four potential inhibitors (ZINC1483899, ZINC1754310, ZINC2269664, and ZINC15729522) were identified These four ligands with phenyl-diketo acid were further subjected to molecular dynamics simulation to compare the dynamics and stability of the protein structure after ligand binding The binding energy analysis was calculated to determine the intermolecular interactions Our results suggested that the four compounds had a binding free energy of -20196, -24202, -18703, and -16902 kJ·mol-1 , for compounds with IDs ZINC1483899, ZINC1754310, ZINC2269664, and ZINC15729522, respectively We concluded that two compounds (ZINC1483899 and ZINC1754310) displayed considerable structural and pharmacological properties and could be probable drug candidates to fight against M tuberculosis parasites

31 citations

Journal ArticleDOI
TL;DR: In this paper, a novel synthetic method for 3-aryl-6-phenyl-2-methylthio/secondaryamino substituted-4(3 H )-pyrimidinones 5 and 9 by the reactions of N -arylamino substituted 1,3-diaza-1, 3-butadienes 1 and 6 with phenyl-, vinyl- and isopropenylketenes is explored.

31 citations


Authors

Showing all 2368 results

NameH-indexPapersCitations
Vivek Sharma1503030136228
Patrick J. Carroll5850513046
Majeti Narasimha Vara Prasad5622715193
Arun Sharma5537111364
Michael Schmittel5338710461
Birgitta Bergman5218710975
Harikesh Bahadur Singh463077372
Lal Chand Rai401344513
B. Dey403548089
Hiriyakkanavar Ila364075633
Jürgen-Hinrich Fuhrhop352085130
Sreebrata Goswami341423228
Gagan B.N. Chainy331074151
J.P. Gaur31643957
Hiriyakkanavar Junjappa303494102
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202321
202254
2021352
2020308
2019293
2018306