Showing papers by "Northampton Community College published in 1972"
TL;DR: The toxic effect produced by the inoculation of large doses of unadapted virus intranasally in mice is associated with the occurrence of an incomplete growth cycle in which there is full production of RNP antigen but no production of haemagglutinin or infective virus.
Abstract: The inoculation of large doses of unadapted influenza virus intranasally into mice results in the production of severe lung lesions. This toxic effect is a result of the entry of virus particles into the lung cells followed by uncoating of the virus ribonucleic acid.
The toxic property of the virus is destroyed by procedures which destroy or modify the nucleic acid such as exposure to monochromatic UV light of wavelength 2537 A, or treatment with hydroxylamine or Bayer A139. Reagents acting on amino groups are particularly effective as they react with the nucleic acid and probably also interfere with penetration of virus into the cell.
Toxicity is also destroyed by mercurials which probably prevent uncoating of the nucleic acid by union with disulphide bonds, and by oxidizing agents such as iodine, permanganate, osmic acid and hydrogen peroxide under condition which suggest possible action on some constituent of the virus containing methionine.
The toxic effect produced by the inoculation of large doses of unadapted virus intranasally in mice is associated with the occurrence of an incomplete growth cycle in which there is full production of RNP antigen but no production of haemagglutinin or infective virus.
7 citations
TL;DR: Age appeared to be a significant factor in that older children performed better than younger ones, but no relation emerged between performance on the pitch matching task and sex, hearing loss, habitual pitch or speech intelligibility.
Abstract: A visible pitch device was constructed around certain components of the Grason-Stadler 1200 series modular programming equipment. Using this device, 60 profoundly and very severely deaf children were given a pitch matching task involving the generation of fundamental voice frequencies at 3 different levels. The performance of the children was generally poor, very few of them having the necessary voluntary control of pitch. Performance was in vestigated in relation to other factors. Age appeared to be a significant factor in that older children performed better than younger ones, but no relation emerged between performance on the pitch matching task and sex, hearing loss, habitual pitch or speech intelligibility.
4 citations
TL;DR: It was emphasized that it is important to accept the fact of the authors' current inability to prevent certain conditions while at the same time trying to devise means of their future prevention, and facing up to such present preventive inabilities often leads to negative ethical as well as practical consequences.
4 citations
TL;DR: In this article, a simple functional test for gold plated integrated circuit lead frames is described and used to evaluate deposits produced under various conditions including those from contaminated electrolytes, and a number of process variables affecting the limiting current density are studied and electrodeposits produced by high speed techniques.
Abstract: SummaryThe masking techniques used in the selective gold plating of planar components has necessitated the investigation of high speed processes for economic reasons. A number of process variables affecting the limiting current density are studied and electrodeposits produced by high speed techniques are examined. A simple functional test for gold plated integrated circuit lead frames is described and is used to evaluate deposits produced under various conditions including those from contaminated electrolytes.
3 citations