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Showing papers by "Northampton Community College published in 2016"


Journal ArticleDOI
TL;DR: In this article, the authors discuss opportunities for change in households and organizations, primarily at short and intermediate timescales, and identify opportunities that have been underused in much of energy policy.
Abstract: Realizing the ambitious commitments of the 2015 Paris Climate Conference (COP21) will require new ways of meeting human needs previously met by burning fossil fuels. Technological developments will be critical, but so will accelerated adoption of promising low-emission technologies and practices. National commitments will be more achievable if interventions take into account key psychological, social, cultural and organizational factors that influence energy choices, along with factors of an infrastructural, technical and economic nature. Broader engagement of social and behavioural science is needed to identify promising opportunities for reducing fossil fuel consumption. Here we discuss opportunities for change in households and organizations, primarily at short and intermediate timescales, and identify opportunities that have been underused in much of energy policy. Based on this survey, we suggest design principles for interventions by governments and other organizations, and identify areas of emphasis for future social science and interdisciplinary research. Meeting carbon emissions commitments while providing necessary energy services means reducing fossil fuel consumption. This Review presents social science insights for increasing adoption of low-carbon and low-consumption technologies and engendering practice changes among households and organizations.

159 citations


Journal ArticleDOI
TL;DR: The effectiveness and safety of oral administration of frozen encapsulated fecal material, prepared from unrelated donors, in treating recurrent CDI are confirmed, and Randomized studies and FMT registries are still needed to ascertain long-term safety.
Abstract: Fecal microbiota transplantation (FMT) has been shown to be safe and effective in treating refractory or relapsing C. difficile infection (CDI), but its use has been limited by practical barriers. We recently reported a small preliminary feasibility study using orally administered frozen fecal capsules. Following these early results, we now report our clinical experience in a large cohort with structured follow-up. We prospectively followed a cohort of patients with recurrent or refractory CDI who were treated with frozen, encapsulated FMT at our institution. The primary endpoint was defined as clinical resolution whilst off antibiotics for CDI at 8 weeks after last capsule ingestion. Safety was defined as any FMT-related adverse event grade 2 or above. Overall, 180 patients aged 7–95 years with a minimal follow-up of 8 weeks were included in the analysis. CDI resolved in 82 % of patients after a single treatment, rising to a 91 % cure rate with two treatments. Three adverse events Grade 2 or above, deemed related or possibly related to FMT, were observed. We confirm the effectiveness and safety of oral administration of frozen encapsulated fecal material, prepared from unrelated donors, in treating recurrent CDI. Randomized studies and FMT registries are still needed to ascertain long-term safety.

148 citations


Journal ArticleDOI
TL;DR: The article will introduce readers to the concept and methods of EGMs and present a demonstration of the EGM tool using existing examples.

138 citations


Journal ArticleDOI
31 May 2016
TL;DR: In this paper, the authors constructed a GIS database of dams in New England irrespective of size and reservoir volume, and compared the characteristics of these existing dams to the attributes of all removed dams over the last ∼25 years.
Abstract: The prolonged history of industrialization, flood control, and hydropower production has led to the construction of 80,000 dams across the U.S. generating significant hydrologic, ecological, and social adjustments. With the increased ecological attention on re-establishing riverine connectivity, dam removal is becoming an important part of large-scale river restoration nationally, especially in New England, due to its early European settlement and history of waterpower-based industry. To capture the broader dimensions of dam removal, we constructed a GIS database of all inventoried dams in New England irrespective of size and reservoir volume to document the magnitude of fragmentation. We compared the characteristics of these existing dams to the attributes of all removed dams over the last ∼25 years. Our results reveal that the National Inventory of Dams significantly underestimates the actual number of dams (4,000 compared to >14,000). To combat the effects of these ecological barriers, dam removal in New England has been robust with 127 dams having been removed between ca. 1990–2013. These removed dams range in size, with the largest number (30%) ranging between 2–4 m high, but 22% of the removed dams were between 4–6 m. They are not isolated to small drainage basins: most drained watersheds between 100–1,000 km2. Regionally, dam removal has re-connected ∼3% (3,770 river km) of the regional river network although primarily through a few select dams where abundant barrier-free river lengths occur, suggesting that a more strategic removal approach has the opportunity to enhance the magnitude and rate of river re-connection. Given the regional-scale restoration of forest cover and water quality over the past century, dam removal offers a significant opportunity to capitalize on these efforts, providing watershed scale restoration and enhancing watershed resilience in the face of significant regional and global anthropogenic changes.

117 citations


Journal ArticleDOI
TL;DR: In this paper, the authors developed a behaviour model and tested it using structural equation modeling of survey data from Vermont, USA (N = 702) to assess social-psychological and cognitive drivers of public-sphere climate actions of Global Warming's Six Americas ‘Alarmed' segment.
Abstract: Surprisingly few individuals who are highly concerned about climate change take action to influence public policies. To assess social-psychological and cognitive drivers of public-sphere climate actions of Global Warming’s Six Americas ‘Alarmed’ segment, we developed a behaviour model and tested it using structural equation modelling of survey data from Vermont, USA (N = 702). Our model, which integrates social cognitive theory, social norms research, and value belief norm theory, explains 36–64% of the variance in five behaviours. Here we show descriptive social norms, self-efficacy, personal response efficacy, and collective response efficacy as strong driving forces of: voting, donating, volunteering, contacting government officials, and protesting about climate change. The belief that similar others took action increased behaviour and strengthened efficacy beliefs, which also led to greater action. Our results imply that communication efforts targeting Alarmed individuals and their public actions should include strategies that foster beliefs about positive descriptive social norms and efficacy. The people that are most concerned about climate change do not always take action. Behavioural modelling shows that concerned citizens are more likely to act if they believe similar people are taking action, and that their action will make a difference.

111 citations


Journal ArticleDOI
TL;DR: This article tested the role of academic language, perspective taking, and complex reasoning in explaining variance in end-of-year GISA scores, and found that these three skill domains not frequently attended to in instruction or in theories of reading comprehension predict outcomes on an assessment of deep reading comprehension.
Abstract: Deep reading comprehension refers to the process required to succeed at tasks defined by the Common Core State Literacy Standards, as well as to achieve proficiency on the more challenging reading tasks in the Program for International Student Assessment (PISA) framework. The purpose of this study was to test the hypothesis that three skill domains not frequently attended to in instruction or in theories of reading comprehension—academic language, perspective taking, and complex reasoning—predict outcomes on an assessment of deep reading comprehension. The Global Integrated Scenario-based Assessment (GISA; O'Reilly, Weeks, Sabatini, Halderman, & Steinberg, 2014) is designed to reflect students' abilities to evaluate texts, integrate information from an array of texts, and use textual evidence to formulate a position, all features of deep reading comprehension. We tested the role of academic language, perspective taking, and complex reasoning in explaining variance in end-of-year GISA scores, contr...

103 citations


Journal ArticleDOI
TL;DR: In this article, the authors identify and prioritize those attributes of bioenergy greenhouse gas (GHG) emissions analysis that are most influential on the length of carbon payback period and demonstrate that evaluation criteria consistency is required to facilitate equitable comparison between projects.
Abstract: The potential greenhouse gas benefits of displacing fossil energy with biofuels are driving policy development in the absence of complete information. The potential carbon neutrality of forest biomass is a source of considerable scientific debate because of the complexity of dynamic forest ecosystems, varied feedstock types, and multiple energy production pathways. The lack of scientific consensus leaves decision makers struggling with contradicting technical advice. Analyzing previously published studies, our goal was to identify and prioritize those attributes of bioenergy greenhouse gas (GHG) emissions analysis that are most influential on length of carbon payback period. We investigated outcomes of 59 previously published forest biomass greenhouse gas emissions research studies published between 1991 and 2014. We identified attributes for each study and classified study cases by attributes. Using classification and regression tree analysis, we identified those attributes that are strong predictors of carbon payback period (e.g. the time required by the forest to recover through sequestration the carbon dioxide from biomass combusted for energy). The inclusion of wildfire dynamics proved to be the most influential in determining carbon payback period length compared to other factors such as feedstock type, baseline choice, and the incorporation of leakage calculations. Additionally, we demonstrate that evaluation criteria consistency is required to facilitate equitable comparison between projects. For carbon payback period calculations to provide operational insights to decision makers, future research should focus on creating common accounting principles for the most influential factors including temporal scale, natural disturbances, system boundaries, GHG emission metrics, and baselines.

80 citations


Journal ArticleDOI
TL;DR: Developing therapies for neurodegenerative diseases will require new scientific approaches that take into account the detrimental effects of altered protein and RNA homeostasis on brain cells, the vulnerabilities of various organelles in certain diseases and aging neurons, and the complex multicellular interactions of the nervous system.
Abstract: Developing therapies for neurodegenerative diseases will require new scientific approaches that take into account the detrimental effects of altered protein and RNA homeostasis on brain cells, the vulnerabilities of various organelles in certain diseases and aging neurons, and the complex multicellular interactions of the nervous system.

67 citations


Journal ArticleDOI
TL;DR: In this article, the role of long-term climate change in driving increases in soil erosion is discussed, assuming that land use and management remain effectively constant, using long daily rainfall data sets from south east England.
Abstract: This commentary discusses the role of long-term climate change in driving increases in soil erosion. Assuming that land use and management remain effectively constant, we discuss changes in the ability of rainfall to cause erosion (erosivity), using long daily rainfall data sets from south east England. An upward trend in mean rainfall per rain day is detected at the century-plus time scale. Implications for soil erosion and sediment delivery are discussed and evidence from other regions reviewed. We conclude that rates of soil erosion may well increase in a warmer, wetter world.

65 citations


Journal ArticleDOI
TL;DR: The results suggest that the familial risk of schizophrenia is expressed in changes in neural activation in the unaffected relatives in the cortical-subcortical working memory network that includes, but is not restricted to the middle prefrontal cortex.
Abstract: Working memory deficits, a core cognitive feature of schizophrenia may arise from dysfunction in the frontal and parietal cortices. Numerous studies have also found abnormal neural activation during working memory tasks in patients' unaffected relatives. The aim of this study was to systematically identify and anatomically localize the evidence for those activation differences across all eligible studies. Fifteen functional magnetic resonance imaging (fMRI) manuscripts, containing 16 samples of 289 unaffected relatives of patients with schizophrenia, and 358 healthy controls were identified that met our inclusion criteria: (1) used a working memory task; and (2) reported standard space coordinates. Activation likelihood estimation (ALE) identified convergence across studies. Compared to healthy controls, patients' unaffected relatives showed decreases in neural activation in the right middle frontal gyrus (BA9), as well as right inferior frontal gyrus (BA44). Increased activation was seen in relatives in the right frontopolar (BA10), left inferior parietal lobe (BA40), and thalamus bilaterally. These results suggest that the familial risk of schizophrenia is expressed in changes in neural activation in the unaffected relatives in the cortical-subcortical working memory network that includes, but is not restricted to the middle prefrontal cortex.

53 citations


Journal ArticleDOI
TL;DR: There is a paucity of research considering falls in older adults with major depressive disorder, and the odds of falling appear to be greater among people with MDD than in previous meta-analyses that have only considered subthreshold depressive symptoms.
Abstract: BACKGROUND: Depressive symptomology is now widely recognized as a key risk factor for falls. The evidence regarding the impact of major depressive disorder (MDD) on falls is unclear. A systematic review and exploratory meta-analysis was undertaken to explore the relationship between MDD and falls. METHODS: Major electronic database were searched from inception till April 2015. Studies that defined MDD and measured falls prospectively in older adults (≥60 years) were included. Studies relying on depressive symptomology alone were excluded. The methodological quality of included articles was assessed and study findings were synthesized using an exploratory meta-analysis. RESULTS: From a potential of 415 articles, only three studies met the inclusion criteria. This included 976 unique older adults with a range of mean age from ≥65 to 83 years. The methodological quality of included studies was satisfactory. None of the included studies' primary aim was to investigate the relationship between MDD and falls. The exploratory meta-analysis demonstrated older adults with MDD are at increased risk of falling compared to non-depressed older adults (odds ratio (OR) 4.0, 95% CI 2.0-8.1, I 2 = 60%, n = 976). CONCLUSION: There is a paucity of research considering falls in older adults with MDD. Our results demonstrate that the odds of falling appear to be greater among people with MDD (OR 4.0) than in previous meta-analyses that have only considered subthreshold depressive symptoms. Given the distinct nature and challenges with MDD, more research is required to better understand the falls risk in this group. Language: en

Journal ArticleDOI
18 Mar 2016-PLOS ONE
TL;DR: Capturing habitual physical activity and sedentary behaviour through brief questionnaires is complex; differences in prevalence estimates can reflect differences in questionnaire structure and content rather than differences in reported behaviour.
Abstract: BACKGROUND: The Physical Activity and Sedentary Behaviour Assessment Questionnaire (PASBAQ), used within the Health Survey for England (HSE) at 5-yearly intervals, is not included annually due to funding and interview-length constraints. Policy-makers and data-users are keen to consider shorter instruments such as the Short-form International Physical Activity Questionnaire (IPAQ) for the annual survey. Both questionnaires were administered in HSE 2012, enabling comparative assessment in a random sample of 1252 adults. METHODS: Relative agreement using prevalence-adjusted bias-adjusted Kappa (PABAK) statistics was estimated for: sufficient aerobic activity (moderate-to-vigorous physical activity [MVPA] ≥150minutes/week); inactivity (MVPA<30minutes/week); and excessive sitting (≥540minutes/weekday). Cross-sectional associations with health outcomes were compared across tertiles of MVPA and tertiles of sitting time using logistic regression with tests for linear trend. RESULTS: Compared with PASBAQ data, IPAQ-assessed estimates of sufficient aerobic activity and inactivity were higher and lower, respectively; estimates of excessive sitting were higher. Demographic patterns in prevalence were similar. Agreement using PABAK statistics was fair-to-moderate for sufficient aerobic activity (0.32-0.49), moderate-to-substantial for inactivity (0.42-0.74), and moderate-to-substantial for excessive sitting (0.49-0.75). As with the PASBAQ, IPAQ-assessed MVPA and sitting each showed graded associations with mental well-being (women: P for trend = 0.003 and 0.004, respectively) and obesity (women: P for trend = 0.007 and 0.014, respectively). CONCLUSIONS: Capturing habitual physical activity and sedentary behaviour through brief questionnaires is complex. Differences in prevalence estimates can reflect differences in questionnaire structure and content rather than differences in reported behaviour. Treating all IPAQ-assessed walking as moderate-intensity contributed to the differences in prevalence estimates. PASBAQ data will be used for population surveillance every 4 to 5 years. The current version of the Short-form IPAQ was included in HSE 2013-14 to enable more frequent assessment of physical activity and sedentary behaviour; a modified version with different item-ordering and additional questions on walking-pace and effort was included in HSE 2015.

Proceedings ArticleDOI
25 Feb 2016
TL;DR: Long-haul optical links are experiencing a transition to coherent techniques because they enable the use of modulation techniques with high spectral efficiency, such as QPSK and QAM, which in turn require highly linear low-noise optical-electrical front-ends.
Abstract: Long-haul optical links are experiencing a transition to coherent techniques because they enable the use of modulation techniques with high spectral efficiency, such as QPSK and QAM [1], which in turn require highly linear low-noise optical-electrical front-ends. To cope with the ever-growing demand for high data rates in the consumer market, the Ethernet standard for long-haul optical links is moving soon from 100 to 400Gb/s. A possible candidate symbol rate to reach this bit rate using complex modulation formats is 64Gbaud.

Journal ArticleDOI
TL;DR: It is shown that tree species richness is strongly positively correlated with maximum tree height across multiple spatial scales in forests of both eastern and western North America, which supports the hypothesis that harshness may be a general mechanism limiting local diversity and explaining diversity gradients within a biogeographic region.
Abstract: Does variation in environmental harshness explain local and regional species diversity gradients? We hypothesise that for a given life form like trees, greater harshness leads to a smaller range of traits that are viable and thereby also to lower species diversity. On the basis of a strong dependence of maximum tree height on site productivity and other measures of site quality, we propose maximum tree height as an inverse measure of environmental harshness for trees. Our results show that tree species richness is strongly positively correlated with maximum tree height across multiple spatial scales in forests of both eastern and western North America. Maximum tree height co-varied with species richness along gradients from benign to harsh environmental conditions, which supports the hypothesis that harshness may be a general mechanism limiting local diversity and explaining diversity gradients within a biogeographic region.

Journal ArticleDOI
TL;DR: This explorative study examines posttraumatic growth among adult female survivors of child sexual abuse and finds that some individuals who actively cope with traumatic events can progress from a negative trajectory toward positive psychological change, often termed post traumatic growth.
Abstract: Potential negative sequelae for survivors of child sexual abuse is well documented. However, growing evidence suggests that some individuals who actively cope with traumatic events can progress from a negative trajectory toward positive psychological change, often termed posttraumatic growth. Current posttraumatic growth theories may be of limited applicability to developmental considerations involved in child sexual abuse. This explorative study examines posttraumatic growth among adult female survivors of child sexual abuse. In-depth interviews were conducted with six participants who believed they had grown through coping with their abuse. Data was analyzed using interpretative phenomenological analysis. Three superordinate and nine subordinate themes were identified and explored. Some participants reported experiencing growth and distress simultaneously. Theoretical and clinical implications are examined in relation to the study's findings.

Journal ArticleDOI
TL;DR: A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year, and found no significant effects of AT on patients’ adherence and adherence attitudes.
Abstract: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients’ psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients. Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms. We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients’ adherence and adherence attitudes. AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders. CRD42015016779

Journal ArticleDOI
TL;DR: Results indicate a complex interplay between childhood adversity, conduct disorder and later violent behaviour in schizophrenia, and suggest that there may be shared aetiological risk factors on a common developmental pathway to violence.

Journal ArticleDOI
TL;DR: The findings revealed that different invitation methods were effective for different ethnic and gender groups, and it is suggested that established protocols of invitation are specifically designed for maximizing the response rate for each population group.
Abstract: NHS Health Checks is a national risk assessment prevention programme for all individuals aged 40-74 that reside in England. Through the systematic assessment of an individual’s ten year disease risk, this programme aims to provide early identification and subsequent management of this risk. However, there is limited evidence on how socio-demographic factors impact on uptake and what influence the invitation method has on uptake to this programme. NHS Health Check data from April 2013 to March 2014 was analysed (N = 50,485) for all 30 GP Practices in Luton, a culturally diverse town in England, UK. Data was collected for age, ethnicity, uptake (attendance and non attendance) and invitation method (letter written, verbal face-to-face, telephone). Actual usage of NHS Health Checks was determined for each ethnic group of the population and compared using Chi-square analysis. The overall uptake rate for Luton was 44 %, markedly lower that the set target of 50–75 %. The findings revealed a variation of uptake in relation to age, gender, level of deprivation. Ethnicity and gender variations were also found, with ‘White British’ ‘Black Caribbean’ and ‘Indian’ patients most likely to take up a NHS Health Check. However, patients from ‘Any Other White Background’ and ‘Black African’ were significantly less likely to uptake an NHS Health Check compared to all other ethnic groups. Ethnicity and gender differences were also noted in relation to invitation method. The findings revealed that different invitation methods were effective for different ethnic and gender groups. Therefore, it is suggested that established protocols of invitation are specifically designed for maximizing the response rate for each population group. Future research should now focus on uncovering the barriers to uptake in particular culturally diverse population groups to determine how public health teams can better engage with these communities.

Proceedings ArticleDOI
25 Feb 2016
TL;DR: High-speed signaling over package substrates is key to delivering the promise of 2.5D integration and applications abound and include high-density memory interfaces, sub-division of large dies to increase yield and lower development time, sub -division of a die to achieve upward or downward scalability, or connecting to an off-chip SerDes or optics engine.
Abstract: High-speed signaling over package substrates is key to delivering the promise of 2.5D integration. Applications abound and include high-density memory interfaces, sub-division of large dies to increase yield and lower development time, sub-division of a die to achieve upward or downward scalability, or connecting to an off-chip SerDes or optics engine. Each of these in-package applications typically has high throughput and onerously low power constraints along with a low-loss channel. Several solutions have been proposed. Interposer substrates [1], or Chip-on-Substrate-on-Wafer [2] allow for very high-density wiring and low power using CMOS transceivers. Their high manufacturing and testing cost makes them prohibitive for anything but high-end applications. A different approach using high-speed ground-referenced single-ended signaling is reported in [3], which is intended for shorter channels up to 4.5mm and a BER of 1e-12. An approach using differential signaling on up to 0.75″ of Megtron 6 material and a BER of 1e-9 is reported in [4]. A comparison is given in Fig. 10.1.1.

Journal ArticleDOI
TL;DR: These findings suggest that B. malayi can be maintained in culture as a valid system for pharmacological and biological studies, at least for several days after removal from the host and adaptation to the new environment.
Abstract: Background Filarial nematodes cause serious and debilitating infections in human populations of tropical countries, contributing to an entrenched cycle of poverty. Only one human filarial parasite, Brugia malayi, can be maintained in rodents in the laboratory setting. It has been a widely used model organism in experiments that employ culture systems, the impact of which on the worms is unknown.

Journal ArticleDOI
TL;DR: The solution of cornea curvature is discussed using a meshless method based on radial basis functions (RBFs) that provides an alternative to corneal topography modeling methods requiring accurate material parameter values that may not be available.

Journal ArticleDOI
TL;DR: The combination of fluid suspension, negative-pressure ventilation, and physiologic perfusion allows the described system to provide a biomimetic mechanical environment not found in existing technologies and especially suited to whole-organ regeneration.
Abstract: Decellularized organs are now established as promising scaffolds for whole-organ regeneration. For this work to reach therapeutic practice, techniques and apparatus are necessary for doing human-scale clinically applicable organ cultures. We have designed and constructed a bioreactor system capable of accommodating whole human or porcine lungs, and we describe in this study relevant technical details, means of assembly and operation, and validation. The reactor has an artificial diaphragm that mimics the conditions found in the chest cavity in vivo, driving hydraulically regulated negative pressure ventilation and custom-built pulsatile perfusion apparatus capable of driving pressure-regulated or volume-regulated vascular flow. Both forms of mechanical actuation can be tuned to match specific physiologic profiles. The organ is sealed in an elastic artificial pleura that mounts to a support architecture. This pleura reduces the fluid volume required for organ culture, maintains the organ's positio...

Journal ArticleDOI
TL;DR: Pragmatic ANXA5 M5 screening and treatment with LMWH in couples undergoing IVF is associated with similar outcome to couples with more favorable prognostic factors, and LMWH treatment should be started prior to clinical pregnancy.

Journal ArticleDOI
TL;DR: In this paper, the authors carried out observations at several reef locations in Puerto Rico to determine the baseline level of snorkeler behavior that threatens coral reefs, but the magnitude of the issue is unknown.

Journal ArticleDOI
TL;DR: In this paper, the authors present a "father-centric" analysis and provide one of the first profiles of non-residential fatherhood in early millennium UK using data from Understanding Society Wave 1, a nationally representative survey of over 30,000 households in the UK.
Abstract: Despite international growth of, and policy interest in, divorce and separation since the 1970s, there is still surprisingly little known about non-residential fatherhood. This paper presents a ‘father-centric’ analysis and provides one of the first profiles of non-residential fatherhood in early millennium UK. Using data from Understanding Society Wave 1, a nationally representative survey of over 30,000 households in the UK, we found 1,070 men self-identifying as having a non-resident child under 16 years old (https://www.understandingsociety.ac.uk). We estimate a prevalence of 5 per cent of British men having a non-resident dependent child. Through latent class analysis, four distinct groups of non-resident fathers are identified: ‘Engaged’ fathers, ‘Less Engaged’ fathers, ‘Disengaged’ fathers and ‘Distance’ fathers. Our analysis finds that non-resident fathers form a heterogeneous group in terms of their socio-demographic profile and family behaviour. It is recommended that legislation and policy concerning fathers in post-separation families are sensitive to variation as well as commonality in socio-economic conditions and family lives and situations.

Journal ArticleDOI
TL;DR: Hip BMD is reduced in older adults with depression, although the effect size is small, and future research should seek to disentangle the independent effects of depression and antidepressant medication on bone loss in older age.
Abstract: PURPOSE Older adults with depression are more likely to experience fractures, but it is unclear if this group has reduced bone mineral density (BMD). We conducted a systematic review and meta-analysis to compare BMD in older adults (60 years or older) with or without depression. METHODS Two independent authors conducted searches of major electronic databases from inception till April 2015. Articles that measured BMD (in g/cm) by dual-energy x-ray absorptiometry at the hip or lumbar spine in a sample with depression (including those with major depressive disorder and depressive symptoms, henceforth called "depression") and a control group were included. A random-effects meta-analysis and meta-regression were conducted. RESULTS Eleven publications across 10 unique studies representing 2511 participants with depression (mean [standard deviation] = 67.4 [6.5] years, 41.8% female) and 32,574 matched controls (mean [standard deviation] = 67.5 [5.9] years, 38.9% female) were included. Only one study confirmed a diagnosis of major depressive disorder, seven studies used a screening measure to define depressive symptoms, and two studies categorized depression by antidepressant medication use. Meta-analysis established that BMD is reduced at the hip in older adults with depression (g = -0.141, 95% confidence interval = -0.220 to -0.062, p < .0001, I = 61%). Meta-analysis from seven studies suggests that lumbar spine BMD may be reduced (g = -0.122, 95% confidence interval = -0.250 to 0.005, p = .06, I = 71%). CONCLUSIONS Hip BMD is reduced in older adults with depression, although the effect size is small. Nevertheless, considering the deleterious impact of hip fractures in this population, the results are important. Future research should seek to disentangle the independent effects of depression and antidepressant medication on bone loss in older age.

Journal ArticleDOI
TL;DR: In this article, the dendritic AlN associated with poor ductility on straightening during continuous casting is believed to always crystallise out in the hcp structure, but it is shown that AlN precipitation can also be present as an fcc phase, and the crystal structure of AlN is dependent on the order in which the austenite and MnS precipitate out during solidification.
Abstract: The dendritic AlN associated with poor ductility on straightening during continuous casting is believed to always crystallise out in the hcp structure. The present paper shows that AlN precipitation can also be present as an fcc phase. Because AlN precipitation is sluggish and needs suitable nucleants like MnS to aid its precipitation, the crystal structure of AlN is dependent on the order in which the austenite and MnS precipitate out during solidification. When austenite forms first, as with the 1%Al transformation induced plasticity (TRIP) steel, MnS nucleants are not available and AlN is forced to precipitate at the austenite grain boundaries as fcc so encouraging intergranular failure. With the 1.5%Al TRIP steel, on solidification, MnS is present in abundance, giving rise to the conventional hcp AlN.

Journal ArticleDOI
TL;DR: In this paper, a review of the literature on critical incidents, trauma, resilience and bereavement suggested that studies exploring the effectiveness of psychological debriefing in general have produced mixed findings, which may be accounted for by methodological flaws and inappropriate application of the intervention.
Abstract: Providing support to schools following a critical incident has become an established part of service delivery for many Educational Psychology Services (EPSs) in the UK. This article offers reflections on the use of Critical Incident Stress Debriefing (CISD) in schools. A review of the literature on critical incidents, trauma, resilience and bereavement suggested that studies exploring the effectiveness of psychological debriefing in general have produced mixed findings, which may be accounted for by methodological flaws and inappropriate application of the intervention. However it is also argued that the underpinning theoretical assumptions of CISD are questionable and, as a result, that Psychological First Aid, a non-intrusive evidence-informed approach, may be more appropriate in this context.

Journal ArticleDOI
TL;DR: In this article, the authors conducted a three-year study of spotted towhees (Aves: Pipilo maculatus) breeding in four undeveloped parks in Portland, OR, USA, to measure park-specific seasonal reproductive output (F) and annual adult survival (SA).
Abstract: Urbanization poses threats to earth’s biota, and retention of remnant native habitat in protected areas within expanding urban boundaries may help alleviate threats to wildlife. However, it is unclear for nearly all nonsynanthropic (i.e., not benefiting from an association with humans) species whether vital rates in urban habitats can sustain populations or if populations persist only through immigration from outside the urban boundary. We conducted a three-year study of spotted towhees (Aves: Pipilo maculatus) breeding in four undeveloped parks in Portland, OR, USA, to measure park-specific seasonal reproductive output (F) and annual adult survival (SA). We developed a stochastic model that combined F and SA with an estimate of first-year survival to measure population growth rate (λ) in all parks assumed to be closed to immigration. F differed among parks but SA did not. Relatively high F was possible because many pairs raised >1 brood/season. When combined with empirical estimates of survival through the 30-day period of post-fledging parental care (SD = 0.645), only 2 of 4 parks were self-sustaining (i.e., λ > 1.0). However, SD reflected substantial loss of fledglings to domestic cats (Felis catus). Assuming no loss to cats and either partial compensatory or additive mortality of fledglings substantially improved prospects of population persistence for declining (sink) populations. Moreover, allowing low levels of immigration to sinks reversed population declines in most parks even when vital rates were insufficient to maintain populations. Our results suggest that nonsynanthropic bird species can persist in urban landscapes, but also that offspring mortality in the post-fledging period may be a critical determinant of population viability.

Journal ArticleDOI
TL;DR: The presence of Loxoconcha, Xestoleberis and Aurila may be suggestive of past seagrass environments, the interpretation of which is strengthened by the presence of other proxies in some collections, such as sirenians, lucinid bivalves, soritid and other benthic foraminiferans as mentioned in this paper.