Northampton Community College

About: Northampton Community College is a education organization based out in Bethlehem, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 3410 authors who have published 4582 publications receiving 130398 citations. The organization is also known as: Northampton County Area Community College.

Holocene sedimentation on the North Norfolk barrier coast in relation to relative sea‐level change

Abstract: Fourteen distinct sedimentary environments have been recognised in the surface sediments of the intertidal zone of the North Norfolk coast. Nine of these can be distinguished in borehole samples on the basis of sedimentological and micro-palaeontological characteristics. They comprise: gravel; channel sand; intertidal sand; intertidal silty sand; intertidal mud and marsh creek; lower salt marsh; upper salt marsh; dune sand; and peat. Sediment accumulations have been penetrated to a depth of −8 m OD and basal peats dated by 14C back to 8410 ± 50 years BP. An overall rate of sediment accumulation (and subsidence) of about 1 m per thousand years is indicated. There is considerable persistence of sedimentary environments in the same areas during up-building, but some erosion and roll-over of the coastal barrier system has occurred. Evidence of positive and negative sea-level tendencies are present in the record, but the main development of the tract is determined by sediment supply to the beach and marshes; positive sea-level tendencies occur at c. 6610, 5970, 4630 and 2790 BP, negative sea-level tendencies occur at 4520 to 4450 and (possibly) 3470 BP.

The role of the human resources manager: strategist or conscience of the organisation?

Abstract: Обсуждается роль менеджера по человеческим ресурсам в компании, объективная сложность его задачи - примирить ценности организации с ценностями этики профессионалов по управлению людьми. По данным исследований, то, насколько профессионалы HR могут влиять на организационную этику, зависит от культуры и структуры организации, а также от уровня доверия к самим HR-специалистам. В основном, ничто не указывает на значительность их влияния.

Benign mucinous metaplasia of the vulva.

Abstract: A 60-year-old woman presented with a 10 year history of vulva1 soreness which had not responded to a short course of conjugated oestrogen cream and, on a separate occasion, to clotrimazole cream for suspected but not proven candidal infection. There was a history of brucellosis, but this was not active. The vulva appeared reddened and atrophic and there was a shallow, depressed red area, approximately 10 mm in diameter on the medial aspect of the right labia minora, just below the clitoris. The depressed red area was biopsied and submitted for histology. In view of the histological findings, which resembled Zoon’s plasma cell vulvitis, a regime of careful personal hygiene and topical dienoestrol cream was advised: this produced a complete and sustained clinical remission.

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function.

Abstract: CACNA1C‐rs1006737 and ZNF804A‐rs1344706 polymorphisms are amongst the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes. As these patients show abnormal verbal fluency (VF) and related brain activation, we asked whether the latter was affected by these polymorphisms (alone and in interaction) – to better understand how they might induce risk. We recently reported effects on functional VF‐related (for ZNF804A‐rs1344706) and structural (for both) connectivity. We genotyped and fMRI‐scanned 54 SCZ, 40 BD and 80 controls during VF. With SPM, we assessed the main effect of CACNA1C‐rs1006737, and its interaction with ZNF804A‐rs1344706, and their interaction with diagnosis, on regional brain activation and functional connectivity (psychophysiological interactions ‐ PPI). Using public data, we reported effects of CACNA1C‐rs1006737 and diagnosis on brain expression. The CACNA1C‐rs1006737 risk allele was associated with increased activation, particularly in the bilateral prefronto‐temporal cortex and thalamus; decreased PPI, especially in the left temporal cortex; and gene expression in white matter and the cerebellum. We also found unprecedented evidence for epistasis (interaction between genetic polymorphisms) in the caudate nucleus, thalamus, and cingulate and temporal cortical activation; and CACNA1C up‐regulation in SCZ and BD parietal cortices. Some effects were dependent on BD/SCZ diagnosis. All imaging results were whole‐brain, voxel‐wise, and familywise‐error corrected. Our results support evidence implicating CACNA1C and ZNF804A in BD and SCZ, adding novel imaging evidence in clinical populations, and of epistasis – which needs further replication. Further scrutiny of the inherent neurobiological mechanisms may disclose their potential as putative drug targets.