Northeastern University (China)

About: Northeastern University (China) is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Microstructure & Control theory. The organization has 36087 authors who have published 36125 publications receiving 426807 citations. The organization is also known as: Dōngběi Dàxué & Northeastern University (东北大学).

Bluetooth Low Energy (BLE) based mobile electrocardiogram monitoring system

Abstract: A wireless electrocardiogram (ECG) monitoring system is developed which integrates Bluetooth Low Energy (BLE) technology. This BLE-based system is comprised of a single-chip ECG signal acquisition module, a Bluetooth module and a smart-phone. Apple's iPhone 4S is selected as the mobile device platform, which embedded with Bluetooth v4.0, Wi-Fi and iOS. In this paper, the monitoring system is able to acquire ECG signals through 2-lead electrocardiogram (ECG) sensor, transmit the ECG data via the Bluetooth wireless link, process and display the ECG waveform in a smart-phone. The results show that implementation of Bluetooth Low Energy (BLE) technology in the existing ECG monitoring system not only eliminates the physical constraints imposed by hard-wired link but also highly reduces the power consumption of the long-term monitoring system.

Smart DNA Machine for Carcinoembryonic Antigen Detection by Exonuclease III-Assisted Target Recycling and DNA Walker Cascade Amplification

Abstract: A synthetic DNA machine performs quasi-mechanical movements in response to external intervention, suggesting the promise of constructing sensitive and specific biosensors. Herein, a smart DNA walker biosensor for label-free detection of carcinoembryonic antigen (CEA) is developed for the first time by a novel cascade amplification strategy of exonuclease (Exo) III-assisted target recycling amplification (ERA) and DNA walker. ERA as the first stage of amplification generates the walker DNA, while the autonomous traveling of the walker DNA on the substrate-modified silica microspheres as the second stage of amplification produces an ultrasensitive fluorescent signal with the help of N-methylmesoporphyrin IX (NMM). The DNA machine as a biosensor could be applied for transducing and quantifying signals from isothermal molecular amplifications, avoiding the complicated reporter elements and thermal cycling. The present biosensor achieves a detection limit of 1.2 pg·mL–1 within a linear range of 10 pg·mL–1 to 1...

Relative humidity sensor based on hollow core fiber filled with GQDs-PVA

Abstract: A novel optic fiber Fabry-Perot interferometer (FPI) based on graphene quantum dots (GQDs) and Polyvinyl Alcohol (PVA) is first proposed for relative humidity (RH) sensing and experimentally demonstrated. The GQDs-PVA compounds are filled into the hollow core fiber (HCF), which is spliced at the end of a single mode fiber (SMF). The refractive index of GQDs-PVA compounds reduces and the length of the FP cavity elongates with the increase of RH, which will lead the reflective spectrum shift to length wavelength, and the variation can characterize the change of RH values. The humidity environment is generated by different saturated saline solution, and the RH values are calibrated by a moisture meter. Experiment results reveal that the wavelength shift shows good linearity with the RH changing from 13.47%RH to 81.34%RH, and the sensitivity is 117.25 pm/%RH with the linearity relevancy of 0.9983. In addition, reversibility and repeatability experiments are carried out and the mean square deviation of six sets of data is 1.425 × 10−3, which indicates good practical development prospects. Taking the practical application into account, the influence of hydrogen and nitrogen in the air on the sensor is studied before humidity experiment, and the experiment results shows that hydrogen and nitrogen in the air have a negligible effect on the humidity sensor proposed in this paper.

Selective electron beam manufactured Ti-6Al-4V lattice structures for orthopedic implant applications: Current status and outstanding challenges

Abstract: Additively manufactured Ti-6Al-4V lattices display unique mechanical and biological properties by virtue of their engineered structure. These attributes enable the innovative design of patient-specific medical implants that (i) are conformal to the intended surgical geometry, (ii) mimic the mechanical properties of natural bone, and (iii) provide superior biological interaction to traditional implants. Selective electron beam melting (SEBM) is an established metal additive manufacturing (AM) process that has enabled the design and fabrication of a variety of novel intricate lattices for implant applications over the last 15 years. This article reviews the technical and clinical characteristics of SEBM Ti-6Al-4V lattices, including (i) the SEBM process and its capabilities, (ii) the structures of human bones with an exhaustive list of corresponding mechanical properties from literature, (iii) the mechanical properties of SEBM Ti-6Al-4V lattices of various designs and their shortcomings when compared to human bones, (iv) microstructural control of SEBM Ti-6Al-4V lattices for improved performance, (v) the lattice manufacturability and associated geometric errors, and (vi) clinical cases. Existing literature on the mechanical response of SEBM Ti-6Al-4V lattice structures is exhaustively evaluated for documentation quality using established theoretical models. This extensive data-set allows novel insights into the effect of lattice design on mechanical response that is not possible with the individual data; and provides a comprehensive database for those who are actively involved in patient-specific SEBM implant design. On this basis, outstanding challenges and research opportunities for SEBM Ti-6Al-4V lattices in the biomedical domain are identified and discussed.