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Institution

Northwestern University

EducationEvanston, Illinois, United States
About: Northwestern University is a education organization based out in Evanston, Illinois, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 75430 authors who have published 188857 publications receiving 9463252 citations. The organization is also known as: Northwestern & NU.


Papers
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Journal ArticleDOI
TL;DR: In this article, the role of agricultural productivity in economic development is addressed in a two-sector model of endogenous growth in which preferences are nonhomothetic and the income elasticity of demand for the agricultural good is less than unitary.

1,168 citations

Journal ArticleDOI
TL;DR: In this article, the authors provide a framework for non-parametric measurement of the jump component in asset return volatility and find that jumps are both highly prevalent and distinctly less persistent than the continuous sample path variation process.
Abstract: A rapidly growing literature has documented important improvements in financial return volatility measurement and forecasting via use of realized variation measures constructed from high-frequency returns coupled with simple modeling procedures. Building on recent theoretical results in Barndorff-Nielsen and Shephard (2004a, 2005) for related bi-power variation measures, the present paper provides a practical and robust framework for non-parametrically measuring the jump component in asset return volatility. In an application to the DM/$ exchange rate, the S&P500 market index, and the 30-year U.S. Treasury bond yield, we find that jumps are both highly prevalent and distinctly less persistent than the continuous sample path variation process. Moreover, many jumps appear directly associated with specific macroeconomic news announcements. Separating jump from non-jump movements in a simple but sophisticated volatility forecasting model, we find that almost all of the predictability in daily, weekly, and monthly return volatilities comes from the non-jump component. Our results thus set the stage for a number of interesting future econometric developments and important financial applications by separately modeling, forecasting, and pricing the continuous and jump components of the total return variation process.

1,167 citations

Journal ArticleDOI
TL;DR: Ubiquitin-binding proteins such as epsins, Hrs, and Vps9 are monoubiquitinated, indicating the general nature of ubiquitin regulation in endocytosis and suggesting new models to explain how recognition of monoubquitin signals may be regulated.
Abstract: Ubiquitin regulates protein transport between membrane compartments by serving as a sorting signal on protein cargo and by controlling the activity of trafficking machinery. Monoubiquitin attached to integral plasma membrane proteins or to associated transport modifiers serves as a regulated signal for internalization into the endocytic pathway. Similarly, monoubiquitin attached to biosynthetic and endocytic membrane proteins is a signal for sorting of cargo into vesicles that bud into the late endosome lumen for delivery into the lysosome. Ubiquitination of trans-acting endocytic proteins is also required for transport, and key endocytic proteins are modified by monoubiquitin. Regulatory enzymes of the ubiquitination machinery, ubiquitin ligases, control the timing and specificity of plasma membrane protein downregulation in such diverse biological processes as cell fate specification and neurotransmission. Monoubiquitin signals appended by these ligases are recognized by endocytic proteins carrying ubiquitin-binding motifs, including UBA, UEV, UIM, and CUE domains. The UIM proteins epsins and Hrs are excellent candidates for adaptors that link ubiquitinated cargo to the clathrin-based sorting machinery at appropriate regions of the endosomal or plasma membranes. Other ubiquitin-binding proteins also play crucial roles in cargo transport, although in most cases the role of ubiquitin-binding is not defined. Ubiquitin-binding proteins such as epsins, Hrs, and Vps9 are monoubiquitinated, indicating the general nature of ubiquitin regulation in endocytosis and suggesting new models to explain how recognition of monoubiquitin signals may be regulated.

1,165 citations

BookDOI
01 Jan 2009-Espiral
TL;DR: Shapiro, Skowronek, and Galvin editaron un libro that puso al dia el estudio de las instituciones al presentar un conjunto de traba-jos representativos de las principales tradiciones in el eststudio del tema as mentioned in this paper.
Abstract: En el ano 2006 Shapiro, Skowronek y Galvin editaron un libro que puso al dia el estudio de las instituciones al presentar un conjunto de traba- jos representativos de las principales tradiciones en el estudio del tema. Los editores no pidieron a los autores que abandonaran su enfoque para mimetizarse -o dialogar- con los demas; en vez de eso, les pidieron que asumieran con claridad su postura, pero presentandola de forma atractiva para aquellos colegas que pertenecian a otras dis- ciplinas o corrientes. El libro reunio importantes aportaciones de John Elster, Clauss Offe, John Ferejohn, Rogers Smith, entre otros. En aquella obra Kathleen Thelen aporto una critica a la teoria del equilibrio interrumpido, que es la forma mas comun de ver el cambio segun dos de los institucionalismos mas prominentes: el his- torico y el de la eleccion racional. Oponiendose a la idea de que las instituciones unicamente cambian en momentos breves de intensa transformacion -casi siempre producto de algun shock exogeno, para luego entrar en largos periodos de reproduc- cion e inercia-, la autora propuso que el cambio institucional muchas veces es un proceso gradual y continuo. Mediante el ana- lisis de las instituciones dedicadas al entrenamiento

1,165 citations

Journal ArticleDOI
TL;DR: The National Kidney Foundation-KDOQI guideline for evaluation, classification, and stratification of chronic kidney disease (CKD) was published in 2002 as mentioned in this paper, but concerns and criticisms arose as new evidence became available since the publication of the original guidelines.

1,165 citations


Authors

Showing all 76189 results

NameH-indexPapersCitations
George M. Whitesides2401739269833
Ralph B. D'Agostino2261287229636
Daniel Levy212933194778
David Miller2032573204840
Ronald M. Evans199708166722
Michael Marmot1931147170338
Robert C. Nichol187851162994
Scott M. Grundy187841231821
Stuart H. Orkin186715112182
Michael A. Strauss1851688208506
Ralph Weissleder1841160142508
Patrick O. Brown183755200985
Aaron R. Folsom1811118134044
Valentin Fuster1791462185164
Ronald C. Petersen1781091153067
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023275
20221,183
202110,513
202010,260
20199,331
20188,301