Institution
Northwestern University
Education•Evanston, Illinois, United States•
About: Northwestern University is a education organization based out in Evanston, Illinois, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 75430 authors who have published 188857 publications receiving 9463252 citations. The organization is also known as: Northwestern & NU.
Topics: Population, Transplantation, Cancer, Health care, Poison control
Papers published on a yearly basis
Papers
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09 Nov 2011TL;DR: The number-word sequence has been used extensively in children's counting from age 2 through 8 as mentioned in this paper, and children's early knowledge about relations between counting and cardinality is discussed.
Abstract: I Number Words.- 1 Introduction and Overview of Different Uses of Number Words.- 2 The Number-Word Sequence: An Overview of Its Acquisition and Elaboration.- II Correspondence Errors in Counting Objects.- 3 Correspondence Errors in Children's Counting.- 4 Effects of Object Arrangement on Counting Correspondence Errors and on the Indicating Act.- 5 Effects of Object Variables and Age of Counter on Correspondence Errors Made When Counting Objects in Rows.- 6 Correspondence Errors in Children's Counting: A Summary.- III Concepts of Cardinality.- 7 Children's Early Knowledge About Relationships Between Counting and Cardinality.- 8 Later Conceptual Relationships Between Counting and Cardinality: Addition and Subtraction of Cardinal Numbers.- 9 Uses of Counting and Matching in Cardinal Equivalence Situations: Equivalence and Order Relations on Cardinal Numbers.- IV Number Words, Counting, and Cardinality: The Increasing Integration of Sequence, Count, and Cardinal Meanings.- 10 Early Relationships Among Sequence Number Words, Counting Correspondence, and Cardinality.- 11 An Overview of Changes in Children's Number Word Concepts from Age 2 Through 8.- References.- Author Index.
1,064 citations
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TL;DR: The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can catalyze cytotoxic reactions.
Abstract: The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can catalyze cytotoxic reactions. Several families of proteins are emerging that control the activity of intracellular metal ions and help confine them to vital roles. These include integral transmembrane transporters, metalloregulatory sensors, and diffusible cytoplasmic metallochaperone proteins that protect and guide metal ions to targets. It is becoming clear that many of these proteins use atypical coordination chemistry to accomplish their unique goals. The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm.
1,061 citations
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1,060 citations
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Yeshiva University1, Harvard University2, Hamilton Health Sciences3, Sunnybrook Research Institute4, Loyola University Chicago5, University of Michigan6, Virginia Commonwealth University7, University of North Carolina at Chapel Hill8, Mayo Clinic9, Duke University10, University of Maryland, Baltimore11, National Institutes of Health12, Wake Forest University13, Indiana University14, Northwestern University15, Baylor College of Medicine16, Washington University in St. Louis17, Yonsei University18, Allegheny General Hospital19, Emory University20, University of Texas at San Antonio21, Vanderbilt University22, University of Pittsburgh23, Rutgers University24, Stanford University25, Indiana University – Purdue University Indianapolis26
TL;DR: In this article, a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary node-negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0cm in the intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features.
Abstract: BackgroundPrior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker. MethodsWe performed a prospective trial involving women with hormone-receptor–positive, human epidermal growth factor receptor type 2 (HER2)–negative, axillary node–negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0 cm in the greatest dimension and intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features. A reverse-transcriptase–polymerase-chain-reaction assay of 21 genes was performed on the paraffin-embedded tumor tissue, and the results were used to calculate a score indicating the risk of breast-...
1,059 citations
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TL;DR: Oligonucleotide surface coverages of hexanethiol 12-mer oligonucleotides on gold nanoparticles were significantly higher than on planar gold thin films, and olig onucleotide spacer sequences improve the hybridization efficiency of oligon nucleotide-modified nanoparticles from approximately 4 to 44%.
Abstract: Using a fluorescence-based method, we have determined the number of thiol-derivatized single-stranded oligonucleotides bound to gold nanoparticles and their extent of hybridization with complementary oligonucleotides in solution. Oligonucleotide surface coverages of hexanethiol 12-mer oligonucleotides on gold nanoparticles (34 ± 1 pmol/cm2) were significantly higher than on planar gold thin films (18 ± 3 pmol/cm2), while the percentage of hybridizable strands on the gold nanoparticles (1.3 ± 0.3 pmol/cm2, 4%) was lower than for gold thin films (6 ± 2 pmol/cm2, 33%). A gradual increase in electrolyte concentration over the course of oligonucleotide deposition significantly increases surface coverage and consequently particle stability. In addition, oligonucleotide spacer sequences improve the hybridization efficiency of oligonucleotide-modified nanoparticles from ∼4 to 44%. The surface coverage of recognition strands can be tailored using coadsorbed diluent oligonucleotides. This provides a means of indire...
1,058 citations
Authors
Showing all 76189 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
Daniel Levy | 212 | 933 | 194778 |
David Miller | 203 | 2573 | 204840 |
Ronald M. Evans | 199 | 708 | 166722 |
Michael Marmot | 193 | 1147 | 170338 |
Robert C. Nichol | 187 | 851 | 162994 |
Scott M. Grundy | 187 | 841 | 231821 |
Stuart H. Orkin | 186 | 715 | 112182 |
Michael A. Strauss | 185 | 1688 | 208506 |
Ralph Weissleder | 184 | 1160 | 142508 |
Patrick O. Brown | 183 | 755 | 200985 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Valentin Fuster | 179 | 1462 | 185164 |
Ronald C. Petersen | 178 | 1091 | 153067 |