Institution
Northwestern University
Education•Evanston, Illinois, United States•
About: Northwestern University is a education organization based out in Evanston, Illinois, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 75430 authors who have published 188857 publications receiving 9463252 citations. The organization is also known as: Northwestern & NU.
Topics: Population, Transplantation, Cancer, Health care, Poison control
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors examined daily equity return volatilities and correlations obtained from high-frequency intraday transaction prices on individual stocks in the Dow Jones Industrial Average and found that the unconditional distributions of realized variances and covariances are highly right-skewed.
2,269 citations
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03 Jan 1997TL;DR: The Stories We Live By as discussed by the authors argues that we are the stories we tell and that each of us discovers what is true and meaningful, in our lives and in ourselves, through the creation of personal myths.
Abstract: Who am I? How do I fit in the world around me? This revealing and innovative book demonstrates that each of us discovers what is true and meaningful, in our lives and in ourselves, through the creation of personal myths. Challenging the traditional view that our personalities are formed by fixed, unchanging characteristics, or by predictable stages through which every individual travels, The Stories We Live By persuasively argues that we are the stories we tell. Informed by extensive scientific research--yet highly readable, engaging, and accessible--the book explores how understanding and revising our personal stories can open up new possibilities for our lives.
2,268 citations
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TL;DR: It is shown that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity, and in vivo osteocalcin can improve glucose tolerance.
2,250 citations
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TL;DR: In this new nanoparticle-based detection system, Au particles are used to complex a 24-base polynucleotide target and exhibit characteristic, exceptionally sharp “melting transitions” which allows one to distinguish target sequences that contain one base end mismatches, deletions, or an insertion from the fully complementary target.
Abstract: Selective colorimetric polynucleotide detection based on Au nanoparticle probes which align in a “tail-to-tail” fashion onto a target polynucleotide is described. In this new nanoparticle-based detection system, Au particles (∼13 nm diameter), which are capped with 3‘- and 5‘-(alkanethiol)oligonucleotides, are used to complex a 24-base polynucleotide target. Hybridization of the target with the probes results in the formation of an extended polymeric Au nanoparticle/polynucleotide aggregate, which triggers a red to purple color change in solution. The color change is due to a red shift in the surface plasmon resonance of the Au nanoparticles. The aggregates exhibit characteristic, exceptionally sharp “melting transitions” (monitored at 260 or 700 nm), which allows one to distinguish target sequences that contain one base end mismatches, deletions, or an insertion from the fully complementary target. When test solutions are spotted onto a C18 reverse-phase thin-layer chromatography plate, color differentia...
2,244 citations
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TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
Abstract: The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.
2,241 citations
Authors
Showing all 76189 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
Daniel Levy | 212 | 933 | 194778 |
David Miller | 203 | 2573 | 204840 |
Ronald M. Evans | 199 | 708 | 166722 |
Michael Marmot | 193 | 1147 | 170338 |
Robert C. Nichol | 187 | 851 | 162994 |
Scott M. Grundy | 187 | 841 | 231821 |
Stuart H. Orkin | 186 | 715 | 112182 |
Michael A. Strauss | 185 | 1688 | 208506 |
Ralph Weissleder | 184 | 1160 | 142508 |
Patrick O. Brown | 183 | 755 | 200985 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Valentin Fuster | 179 | 1462 | 185164 |
Ronald C. Petersen | 178 | 1091 | 153067 |